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山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (5): 28-34.doi: 10.6040/j.issn.1671-7554.0.2024.0186

• 慢性气道疾病的精准个体化诊疗——专家综述 • 上一篇    

神经心理性哮喘

王婷1,2,3,张丽4,王刚1,2,3   

  1. 1. 四川大学华西医院呼吸与危重症医学科, 呼吸疾病临床医学研究中心, 四川 成都 610041;2. 四川大学华西医院呼吸和共病全国重点实验室, 四川 成都 610041;3. 四川大学疾病分子网络前沿科学中心肺免疫炎症研究室, 四川 成都 610041;4. 四川大学华西医院中西医结合中心内科, 四川 成都 610041
  • 发布日期:2024-05-29
  • 通讯作者: 王刚. E-mail: wcums-respiration@hotmail.com
  • 基金资助:
    国家自然科学基金国际合作重点项目(81920108002);国家自然科学基金青年科学基金(31701011)

Neuropsychological asthma

WANG Ting1,2,3, ZHANG Li4, WANG Gang1,2,3   

  1. 1. Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China;
    2. State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China;
    3. Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, Sichuan University, Chengdu 610041, Sichuan, China;
    4. Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China
  • Published:2024-05-29

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摘要： 支气管哮喘(简称哮喘)是常见的慢性气道炎症疾病,存在明显的异质性。应用多维度评估识别哮喘的可治疗特质,可望提高哮喘控制并实现临床缓解。以焦虑、抑郁等为主要表现的神经心理功能异常是哮喘肺外可治疗特质评估的重要内容。合并焦虑和/或抑郁可恶化哮喘症状,降低生活质量,增加急性发作,因此神经心理性哮喘作为一特殊哮喘表型而备受关注。本文对神经心理性哮喘的临床流行病学、神经心理因素对哮喘的影响、神经心理性哮喘发生机制以及评估和治疗手段进行述评,为神经心理性哮喘未来的研究和管理提供参考。

关键词: 支气管哮喘, 焦虑, 抑郁, 神经心理功能异常

Abstract: Bronchial asthma(asthma)is a heterogeneous disease characterized by chronic airway inflammation. Application of multidimensional assessment to identify treatable traits in asthma is expected to improve asthma control and achieve clinical remission. Neuropsychological dysfunction, including anxiety and depression, is important component of the assessment of extrapulmonary treatable traits in asthma. Comorbid anxiety and/or depression can worsen asthma symptoms, reduce quality of life, and increase acute exacerbations, and thus neuropsychological asthma has gained attention as a specific asthma phenotype. This article reviews the epidemiology, clinical consequences, underlying mechanisms, screening tools, and treatments of neuropsychological asthma, in order to provide some information for future research and management of neuropsychological asthma.

Key words: Bronchial asthma, Anxiety, Depression, Neuropsychological dysfunction

中图分类号: 

  • R562.25
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