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山东大学学报 (医学版) ›› 2022, Vol. 60 ›› Issue (1): 65-70.doi: 10.6040/j.issn.1671-7554.0.2021.0508

• 临床医学 • 上一篇    下一篇

磁珠耳穴贴压联合重复经颅磁刺激对脑卒中后抑郁的疗效

赵璇1,李晓鹏2,李剑1,田彬1,王广君1   

  1. 1.东营市胜利医院神经内科, 山东 东营 257000;2.胜利油田中心医院理疗科, 山东 东营 257000
  • 发布日期:2022-01-08
  • 通讯作者: 李晓鹏. E-mail:lxpfirstclass@163.com
  • 基金资助:
    2020年中国石化集团胜利石油管理局科技攻关项目(GKY2002)

Therapeutic effects of auricular points sticking with magnetic beads combined with repeated transcranial magnetic stimulation on post-stroke depression

ZHAO Xuan1, LI Xiaopeng2, LI Jian1, TIAN Bin1, WANG Guangjun1   

  1. 1. Department of Neurology, Dongying Shengli Hospital, Dongying 257000, Shandong, China;
    2. Department of Physiotherapy, Shengli Oilfield Central Hospital, Dongying 257000, Shandong, China
  • Published:2022-01-08

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摘要： 目的 探讨磁珠耳穴贴压联合重复经颅磁刺激(rTMS)治疗脑卒中后抑郁患者的效果以及对血清中的瞬时受体电位通道1蛋白(TRPC1)、5-羟色胺(5-HT)、S100β蛋白水平的影响。 方法 选取脑卒中后抑郁的患者120例,采用随机数字表分为对照组(抗抑郁药物治疗)、rTMS组(抗抑郁药物+rTMS治疗)、耳穴组(抗抑郁药物+磁珠耳穴贴压治疗)、rTMS+耳穴组(抗抑郁药物+rTMS+磁珠耳穴贴压治疗)各30例,治疗疗程为4周;对比4组治疗前后的汉密尔顿抑郁量表(HAMD)评分、临床疗效和血清TRPC1、5-HT、S100β水平变化及不良反应。 结果 治疗前,对照组、rTMS组、耳穴组及rTMS+耳穴组的HAMD评分,差异无统计学意义(P>0.05);治疗后,rTMS+耳穴组的HAMD评分低于对照组、rTMS组及耳穴组(P<0.05); rTMS组、耳穴组的HAMD评分低于对照组(P<0.05);治疗前,对照组、rTMS组、耳穴组及rTMS+耳穴组的血清TRPC1、5-HT、S100β水平差异无统计学意义(P>0.05);治疗后,rTMS+耳穴组患者的血清S100β水平低于对照组、rTMS组及耳穴组(P<0.05),TRPC1、5-HT水平高于对照组、rTMS组、耳穴组(P<0.05);治疗后,rTMS组、耳穴组的血清S100β水平低于对照组(P<0.05),TRPC1、5-HT水平高于对照组(P<0.05);经过治疗,rTMS+耳穴组患者的总有效率高于对照组、rTMS组、耳穴组(P<0.05),rTMS组、耳穴组的总有效率明显高于对照组(P<0.05)。 结论 磁珠耳穴贴压联合rTMS治疗对于脑卒中后抑郁患者有着肯定的疗效,能有效调节血清TRPC1、5-HT及S100β水平,明显改善患者的抑郁症状。

关键词: 重复经颅磁刺激, 磁珠耳穴贴压, 脑卒中后抑郁, 瞬时受体电位通道1蛋白, 5-羟色胺, S100β蛋白

Abstract: Objective To investigate the effects of auricular points sticking with magnetic beads combined with repeated transcranial magnetic stimulation(rTMS)on post-stroke depression patients and the effects on the levels of serum transient receptor potential channel 1 protein(TRPC1), serotonin(5-HT), and S100β protein. Methods A total of 120 patients with post-stroke depression were selected and randomly divided into the control group(antidepressant treatment), rTMS group(antidepressant + rTMS), auricular points group(antidepressant + auricular points sticking with magnetic beads treatment), and rTMS + auricular points group(antidepressants + rTMS + auricular points sticking with magnetic beads treatment), with 30 cases in each group and treatment course of 4 weeks. The Hamilton Depression Scale(HAMD)score, clinical efficacy, changes of TRPC1, 5-HT and S100β, and adverse reactions in the four groups were compared. Results Before treatment, there was no significant difference in the HAMD score among the four groups(P>0.05). After treatment, the HAMD score was lower in the rTMS + auricular point group than in other three groups(P<0.05), and the HAMD score in the rTMS and auricular points groups was lower than that in the control group(P<0.05). Before treatment, there were no significant differences in the levels of TRPC1, 5-HT and S100β among the four groups(P>0.05). After treatment, the level of S100β in the rTMS + auricular points group was lower than that in other three groups(P<0.05). The levels of TRPC1 and 5-HT in the rTMS + auricular points group were higher than those in the other three groups(P<0.05). The level of S100β in the rTMS and auricular points groups was lower than that in the control group(P<0.05), and the levels of TRPC1 and 5-HT were higher than in the control group(P<0.05). The total effective rate of the rTMS + auricular points group was higher than that of the other three groups(P<0.05). The total effective rate of the rTMS and auricular points groups was higher than that of the control group(P<0.05). Conclusion Auricular points sticking with magnetic beads combined with rTMS has positive effects in the treatment of post-stroke depression patients, which can effectively adjust the levels of serum TRPC1, 5-HT and S100β, and significantly improve the depression symptoms.

Key words: Repetitive transcranial magnetic stimulation, Auricular point sticking with magnetic beads, Post-stroke depression, Transient receptor potential channel 1 protein, Serotonin, S100β protein

中图分类号: 

  • R743.3
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