山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (5): 35-42.doi: 10.6040/j.issn.1671-7554.0.2024.0144
• 慢性气道疾病的精准个体化诊疗——专家综述 • 上一篇
徐芳1,田国雄1,2,孙倍倍1,陈馨怡1,陈高莹1,2,张睿琦2,应颂敏1,2,吴妙莲2,张超1,吴优倩2
XU Fang1, TIAN Guoxiong1,2, SUN Beibei1, CHEN Xinyi1, CHEN Gaoying1,2, ZHANG Ruiqi2, YING Songmin1,2, WU Miaolian2, ZHANG Chao1, WU Youqian2
摘要: 哮喘是一种高度异质性疾病,多种效应细胞与细胞因子参与其发生发展。对于重度哮喘,传统的高剂量吸入性糖皮质激素治疗通常难以控制症状,患者可表现为持续的气流受限与症状恶化,伴随生存质量下降及医疗负担增加。目前,靶向阻断效应细胞或细胞因子的生物制剂作为附加疗法为重度哮喘患者提供了新的选择。近年来也有研究开创性地将新型细胞疗法,如干细胞疗法或嵌合抗原受体T(chimeric antigen receptor T, CAR-T)细胞疗法应用于重度哮喘的治疗。本文将对治疗重度哮喘的生物制剂以及目前作为潜在治疗策略的新型细胞疗法的研究进展进行综述,阐述目前具有应用前景的生物疗法及其作用机制、疗效和安全性等,并在此基础上,从长期疗效和安全性、精准医疗、患者可及性、跨学科合作等方面展望生物疗法与细胞疗法作为重度哮喘治疗策略的未来发展趋势。
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