吸入布地奈德/福莫特罗治疗新型冠状病毒感染后咳嗽的疗效

doi:10.6040/j.issn.1671-7554.0.2023.0280

摘要/Abstract

摘要： 目的探讨吸入布地奈德/福莫特罗治疗新型冠状病毒感染后急性、亚急性咳嗽的有效性及安全性。方法回顾性收集2022年12月1日至2023年1月30日在山东第一医科大学附属省立医院呼吸与危重症医学科就诊,接受布地奈德/福莫特罗(160 μg/4.5 μg)治疗的新型冠状病毒感染后急性、亚急性咳嗽的患者资料。视觉模拟评分(VAS)评价咳嗽严重程度。结果共有168例患者纳入本研究,其中男73例,女95例,18~80岁,平均(47.02±15.13)岁;患者咳嗽时间5~60 d,平均(26.18±12.62)d。治疗总有效率为84.51%,患者平均治疗(5.29±2.45)d后,咳嗽症状明显好转;治疗后,VAS从(5.91±1.77)分降至(1.35±2.12)分(P<0.001)。纳入研究的患者中共有5例出现轻度不良反应(如声音嘶哑、头痛、心悸),不良反应率为2.98%,无严重不良反应发生。结论布地奈德/福莫特罗治疗新型冠状病毒感染后咳嗽的临床疗效显著,能快速缓解咳嗽症状,具有临床推广价值。

关键词: 新型冠状病毒感染, 急性咳嗽, 亚急性咳嗽, 布地奈德/福莫特罗, 治疗

Abstract: Objective To observe the efficacy and safety of Budesonide/Formoterol in the treatment of SARS-CoV-2-associated cough. Methods Clinical data of patients with acute or subacute cough after SARS-CoV-2 infection who received Budesonide/Formoterol(160 μg∶ 4.5 μg)during Dec. 1, 2022 and Jan. 30, 2023 were retrospectively analyzed. Severity of cough was evaluated with visual analogue scale(VAS). Results A total of 168 patients were involved, including 73 males and 95 females. The patients aged 18 to 80 years, average(47.02±15.13)years. Cough duration ranged from 5 to 60 days, average(26.18±12.62)days. The total effective rate of treatment was 84.51%, and the cough symptoms significantly improved after an average of(5.29±2.45)days of treatment. After treatment, the VAS score decreased from(5.91±1.77)to(1.35±2.12),(P<0.001). Mild adverse reactions such as voice hoarse, headache and palpitation occurred in 5 cases, with an adverse reaction rate of 2.98%. No serious adverse reactions occurred. Conclusion Budesonide/Formoterol has a significant clinical effect in the treatment of cough after SARS-CoV-2 infection and can quickly relieve cough symptoms, which has clinical application value.

Key words: SARS-CoV-2 infection, Acute cough, Subacute cough, Budesonide/Formoterol, Treatment

中图分类号:

R562.2+1

王骏仁,李道卫,王星光,姜淑娟. 吸入布地奈德/福莫特罗治疗新型冠状病毒感染后咳嗽的疗效[J]. 山东大学学报 (医学版), 2023, 61(8): 50-53.

WANG Junren, LI Daowei, WANG Xingguang, JIANG Shujuan. Clinical efficacy of Budesonide/Formoterol in the treatment of SARS-CoV-2-associated cough[J]. Journal of Shandong University (Health Sciences), 2023, 61(8): 50-53.

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