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山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (8): 88-94.doi: 10.6040/j.issn.1671-7554.0.2020.0604

• 脑科学与类脑智能研究专题 • 上一篇    下一篇

靶向小类泛素化修饰的胶质瘤治疗新策略

陈安静1,2,*(),张训1,2   

  1. 1. 山东大学齐鲁医院神经外科，山东大学脑与类脑科学研究院, 山东 济南 250012
    2. 山东省脑功能重构重点实验室, 山东 济南 250012
  • 收稿日期:2020-04-15 出版日期:2020-08-01 发布日期:2020-08-07
  • 通讯作者: 陈安静 E-mail:chenaj@sdu.edu.cn
  • 作者简介:陈安静，研究员，山东省“泰山学者”青年专家，山东大学生物化学与分子生物学博士。研究方向为SUMO化和泛素化修饰调控脑胶质瘤恶性进展与转化的分子机制。以项目负责人身份主持国家自然科学基金、中国博士后基金面上项目、山东省重点研发计划和山东省自然科学基金等。累计发表SCI收录论文40篇，以通讯作者和第一作者在《Clinical Cancer Research》《Journal of Virology》等期刊发表文章。曾获山东省优秀科技创新成果奖、山东省医学科技奖和山东大学学生“五·四”青年科学奖等。
  • 基金资助:
    山东省泰山学者人才工程(tsqn201909173);中国博士后基金(2018M642666)

The new strategies of targeting SUMOylation in the treatment of glioma

Anjing CHEN1,2,*(),Xun ZHANG1,2   

  1. 1. Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan 250012, Shandong, China
    2. Shandong Key Laboratory of Brain Function Remodeling, Jinan 250012, Shandong, China
  • Received:2020-04-15 Online:2020-08-01 Published:2020-08-07
  • Contact: Anjing CHEN E-mail:chenaj@sdu.edu.cn

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摘要：

蛋白质的小类泛素(SUMO)化修饰(SUMOylation)是一种动态的翻译后修饰，涉及了细胞一系列的生理过程。值得注意的是，SUMO化也在多种癌症病理过程中发挥重要作用，其中包括严重危害人类健康的脑胶质瘤。本文回顾分析SUMO化修饰与胶质瘤相关的核心文献，着重探究SUMO化修饰过程中的关键靶点，可望作为胶质瘤治疗有潜力的新方法，为其精准靶向治疗提供新的策略。

关键词: 胶质瘤, 小类泛素化修饰, 恶性进展, 靶向治疗

Abstract:

Small ubiquitin-like modification (SUMOylation), a dynamic process of post-translational modification, involves a series of physiological changes within the cells. SUMOylation also plays an important role in the pathological progresses of a number of cancers including the fatal disease, glioma. In this essay, we reviewed the key aspects of SUMOylation in association with glioma from the literatures and highlighted that some potential targets were expected to be therapeutic strategies in the treatment of glioma.

Key words: Glioma, SUMOylation, Malignant progression, Targeted therapy

中图分类号: 

  • R456

图1

胶质瘤SUMO化修饰增强参与调节多重细胞过程并导致恶性进展"

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