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山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (8): 67-73.doi: 10.6040/j.issn.1671-7554.0.2020.430

• 脑科学与类脑智能研究专题 • 上一篇    下一篇

脑胶质瘤抑制性免疫微环境形成机制及研究进展

李刚*(),薛皓,邱伟,赵荣荣   

  1. 山东大学齐鲁医院神经外科，山东 济南 250012
  • 收稿日期:2020-03-24 出版日期:2020-08-01 发布日期:2020-08-07
  • 通讯作者: 李刚 E-mail:dr.ligang@sdu.edu.cn
  • 作者简介:李刚，医学博士，主任医师，山东大学特聘教授及二级岗专家，博士研究生导师，泰山学者特聘专家；现任山东大学齐鲁医院神经外科主任，山东大学脑与类脑科学研究院副院长；兼任山东省医学会神经外科分会主任委员，中华医学会神经外科分会委员及脑血管病外科学组副组长，中国医师协会神经外科医师分会常务委员及脑胶质瘤专业委员会副主任委员；同时担任《中华神经外科杂志》《中华神经外科杂志(英文)》《Neurosurgery》中文版等多家期刊的编委|主要研究方向为胶质瘤抑制性免疫微环境形成机制、胶质瘤标志物与胶质瘤早期精准诊疗；先后承担国家自然科学基金面上项目5项、国家自然科学基金重大培育项目1项、国家“十二五”重大科技支撑计划子课题2项、省部级课题10余项；获山东省科技进步一等奖2项、教育部科技进步二等奖1项、中华医学科技三等奖1项、山东省科技进步二等奖4项及山东省高校优秀科技成果一等奖2项；授权国家发明专利6项、实用新型专利5项；以第一或通讯作者在《Autophagy》《J Pineal Res》《Oncogene》《Brain Pathol》《Int J Cancer》等著名学术期刊发表SCI收录论文80余篇；主编、副主编及参编著作10余部
  • 基金资助:
    国家自然科学基金(81874083);山东省重点研发计划(2017CXGC1203);泰山学者基金(ts201511093)

Research advances in the formation of glioma immunosuppressive microenvironment

Gang LI*(),Hao XUE,Wei QIU,Rongrong ZHAO   

  1. Department of Neurosurgery, Qilu Hospital, Cheeloo College of Meicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2020-03-24 Online:2020-08-01 Published:2020-08-07
  • Contact: Gang LI E-mail:dr.ligang@sdu.edu.cn

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摘要：

人脑胶质瘤是中枢神经系统最常见的恶性肿瘤，手术切除及放化疗等传统治疗方法效果不理想。近年来，多种免疫治疗策略相继问世，然而由于胶质瘤抑制性免疫微环境的存在，上述疗法仍不尽如人意。探究胶质瘤抑制性免疫微环境的形成机制，是胶质瘤免疫治疗亟需解决的问题。本文结合相关研究领域最新研究进展，对胶质瘤抑制性微环境的研究方向进行总结及展望，为系统全面了解胶质瘤免疫微环境提供重要参考。

关键词: 胶质瘤, 抑制性免疫微环境, 免疫治疗

Abstract:

As the most common and lethal primary tumor of the central nervous system, glioma responds poorly to conventional treatments. Although novel immunotherapies have been adopted, the prognosis of glioma patients is still poor due to the immunosuppressive microenvironment. Therefore, a thorough investigation of the formation mechanism of glioma immunosuppressive microenvironment has become the focus. Based on the latest research progress, we summarized and prospected the future research direction of glioma immunosuppressive microenvironment, hoping to provide reference for the better understanding of this disease.

Key words: Glioma, Immunosuppressive microenvironment, Immunotherapy

中图分类号: 

  • R739.41
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