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Comparison and clinical significance of thrombelastogram in patients with cerebral infarction or cerebral hemorrhage
- LI Chunfeng, LI Jing, ZHAO Xueying, ZHU Yufang, QI Yingzhi, QIU Xia, ZHANG Min, ZHOU Zhongmin, LANG Xiaoyan, LU Xin
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Journal of Shandong University (Health Sciences). 2019, 57(12):
80-85.
doi:10.6040/j.issn.1671-7554.0.2019.432
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Objective To investigate the changes of thromboelastogram(TEG)indicators in patients with cerebral infarction and cerebral hemorrhage, and the correlation with the results of traditional coagulation tests. Methods A total of 73 cases of cerebral infarction and 46 cases of cerebral hemorrhage admitted during March 2018 and March 2019 were selected as the research subjects, and 20 healthy people who received physical examination in our hospital during the same period served as healthy controls. The main indicators of TEG and traditional coagulation function indicators were detected, including coagulation reaction time(R value), coagulation formation time(K value), blood clot formation rate or α angle(Angle), maximum thrombus amplitude(MA), coagulation index(CI), prothrombin time(PT), activated partial prothrombin time(APTT), thrombin time(TT), fibrinogen concentration(FIB), D-Dimer, and platelet counts. Results There were significant differences in the values of K, Angle, MA and CI among the 3 groups(P<0.05)while no significant difference in the R value. The Angle, MA and CI values of the hemorrhage group were lower 山 东 大 学 学 报 (医 学 版)57卷12期 -李春凤,等.脑梗死与脑出血患者的血栓弹力图结果比较及其临床意义 \=-than those of control group, and the Angle, MA and CI value of the infarction group were higher than those of the controls. The K value of hemorrhage group was higher than that of infarction group, while the platelet count(PLT)was lower(both P<0.05). The APTT in the hemorrhage group was lower than that in the infarction group, while PT and D-Dimer were higher(all P<0.05). There were no significant differences in FIB and TT between the two groups. There were positive correlations between R and APTT, between K, PT and Angle, between MA, CI, FIB and PLT, while there were negative correlation between K and FIB, between PLT, MA and PT, between TT, CI, PT and APTT(all P<0.05). Conclusion Cerebral infarction and cerebral hemorrhage are complicated in the acute onset stage. The traditional coagulation function test is one-sided and untimely. TEG can reflect the true coagulation status more intuitively and accurately, so as to improve the diagnosis and treatment efficiency.
