Table of Content

  

10 June 2018
Volume 56 Issue 6

Application of Suiplus semen analysis automatic detection system and manual counting using hemocytometer in mouse semen analysis

SU Xiaohui, SUN Mingqi, ZHANG Meijie, FANG Li, LUO Dandan, CHEN Guoping, YU Chunxiao, GUAN Qingbo

Journal of Shandong University (Health Sciences). 2018, 56(6):  1-5.  doi:10.6040/j.issn.1671-7554.0.2018.109

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Objective To compare the functions and differences of Suiplus semen analysis(SSA)automatic detection system and manual counting using hemocytometer in mouse semen analysis. Methods The general morphology, concentration, kinematic parameters and motility of sperm samples of adult male C57BL/6 mice were measured by the above two methods respectively. The data were statistically analyzed. Results The sperm concentration detected by the SSA system was significantly higher than that detected by manual counting(P<0.05). The results of the SSA system showed that the straight line velocity was(25.41±6.42)μm/s, the elocity in curvilinear velocity was(74.13±5.82)μm/s, the linearity was(24.63±8.43)%, and the straightness was(41.00±9.62)%. The proportion of motile sperm detected by the SSA system was significantly higher than that detected by manual counting(P<0.05). Conclusion SSA automatic 山 东 大 学 学 报 (医 学 版)56卷6期 -苏晓慧,等.穗加精液分析自动检测系统与血细胞计数板人工计数法在小鼠精液分析中的应用 \=-detection system can directly observe the morphology and movement of sperm, and analyze the corresponding parameters simply but accurately, which provides a convenient and reliable method for semen analysis.

Protective effect of flavonoid components extracted from Diopyros Kaki on oxidative stress induced by OGD/R in HT22 cells

CUI Chunying, SHEN Chao, HONG Yan, CHEN Jian, LIU Xueping

Journal of Shandong University (Health Sciences). 2018, 56(6):  6-12.  doi:10.6040/j.issn.1671-7554.0.2017.1234

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Objective To investigate the protective effect of flavonoid components extracted from Diopyros Kaki(FLDK)on oxidative stress induced by oxygen glucose deprivation/reperfusion(OGD/R)in HT22 cells. Methods HT22 cells were randomly divided into normal control group(Control group), OGD/R group, OGD/R+FLDK treatment group(OGD/R+FLDK group), OGD/R +FLDK+transcription factor NF-E2 related factors(Nrf2)gene knockdowm group(OGD/R+FLDK+si-Nrf2 group). OGD/R model of HT22 cells were established by oxygen glucose deprivation for 3 h followed by a 24 h reperfusion; FLDK was added at the beginning of the OGD, and continued to the end of reperfusion; using si-Nrf2 to block the Nrf2 pathway. CCK-8 assay was used to detect cell viability; lactate deoxidizing enzyme(LDH)assay was used to detect the cell injury rate; related kits were used to detect the MDA content, 山 东 大 学 学 报 (医 学 版)56卷6期 -崔春英,等.柿叶黄酮提取物对氧糖剥夺/复糖复氧损伤的HT22细胞氧化应激的保护作用 \=-SOD and GSH-Px activity; DCFH-DA fluorescent probe was used to detect the reactive oxygen species(ROS)levels; Western blotting was used to detect the nuclear-Nrf2 and HO-1 proteins expression. Results Compared with the control group, the cell activity was decreased(P<0.001); the cell injury rate was increased(P<0.001); the ROS and MDA content were increased(P<0.001); the antioxidant enzyme SOD and GSH-Px activity were decreased(P<0.001); HO-1 protein expression was increased(P=0.009)and the nuclear-Nrf2 protein expression was increased(P=0.016)in the OGD/R group. Compared with the OGD/R group, the cell activity was increased(P<0.001), the cell injury rate was decreased(P<0.001), the ROS and MDA content were decreased(P<0.001), the antioxidant enzyme SOD and GSH-Px activity were increased(P<0.001), the HO-1 protein expression was increased(P<0.001)and nuclear-Nrf2 protein expression was increased(P=0.005). Compared with the OGD/R+FLDK group, the HO-1 protein expression was decreased(P<0.001),the nuclear-Nrf2 protein was decreased(P=0.001), the ROS level was increased(P<0.001)and the cell activity was decreased(P<0.001). Conclusion FLDK can attenuate the oxidative stress in HT22 cells induced by OGD/R injury, and it may be associated with the activation of the Nrf2/HO-1 signaling pathway.

Construction and in vitro anticancer evaluation of redox-sensitive polymeric micelles based on PEO-PPO-SS-DTX conjugate

LIU Xin, ZHANG Pei, HE Wenxiu, LUAN Yuxia

Journal of Shandong University (Health Sciences). 2018, 56(6):  13-20.  doi:10.6040/j.issn.1671-7554.0.2018.190

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Objective To synthesize, characterize and evaluate allyl polyoxyethylene-polyethylene oxide(PEO-PPO)-SS-docetaxel(DTX)conjugate. Methods The PEO-PPO-SS-DTX conjugate was synthesized and confirmed structurally by nuclear magnetic resonance hydrogen spectrum(¹H-NMR)and fourier transform infrared spectroscopy(FT-IR). Then the PEO-PPO-SS-DTX micelles were prepared and the assembly behavior of the PEO-PPO-SS-DTX conjugate in aqueous solution was studied. The average size of the micelles, critical micelle concentration(CMC), and drug loading(DL)content and hemolysis rate(HR)were measured by dynamic light scattering instrument, fluorescence, and UV spectrophotometry, respectively. The cytotoxicity experiment and cell uptake experiment were used to evaluate its in vitro anticancer efficacy. Results The PEO-PPO-SS-DTX conjugate and micelles were prepared successfully. The PEO-PPO-SS-DTX conjugate could assemble into the spherical micelles spontaneously in aqueous solution. The average size of the micelles was(159.0±4.4)nm with poly dispersity index(PDI)of 0.18±0.01. The CMC was about 5.0 μg·mL^-1, drug loading(DL)content was 8.3%, and the hemolysis rate(HR)was less than 5%. The PEO-PPO- 山 东 大 学 学 报 (医 学 版)56卷6期 -刘新,等.氧化还原敏感PEO-PPO-SS-DTX聚合物胶束的构建及体外抗肿瘤评价 \=-SS-DTX micelles had excellent anti-tumor efficiency and cell uptake rate against Hep1-6 cells. Conclusion The PEO-PPO-SS-DTX conjugate has excellent properties and great potentical for clinical application.

Cooperative pH-sensitivity polyion complex micelles for co-delivery of doxorubicin and paclitaxel

ZHU Yixin, FAN Xiaohui, CHEN Yan, LI Lingbing

Journal of Shandong University (Health Sciences). 2018, 56(6):  21-28.  doi:10.6040/j.issn.1671-7554.0.2017.875

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Objective To achieve co-delivery of paclitaxel(PTX)and doxorubicin(DOX)by pH-sensitive polyion complex micelles, and to evaluate its effects in vitro and in vivo. Methods Amphiphilic polyelectrolyte/prodrug micelles were constructed via synergistic electrostatic interactions between slightly positively charged pluronic F127-chitosan copolymer(F127-CS)and negatively charged cis-aconityl-doxorubicin(CA-DOX)prodrug. Mixed micelles were prepared using pluronic P105(P105)and F127-CS/CA-DOX, and poorly water-soluble anticancer drug PTX was incorporated into mixed micelles to realize the co-delivery of DOX and PTX. The particle size of micelles was measured and the critical micelle concentration(CMC)was observed by the pyrene fluorescence probe method. Finally, the characteristics of micelles such as in vitro drug release, in vitro cell uptake and in vivo pharmacodynamics studies were evaluated. Results The pH-sensitive micelles were prepared successfully. The average particle diameter of the micelles was 179.3 nm and the CMC was 0.039 mg/mL. DOX and PTX release from polymeric micelles followed a pH-dependent manner. The results of cell uptake studies exhibited that both DOX and PTX could be delivered into cells by P105/F127-CS/CA-DOX mixed micelles effectively. The in vivo pharmacodynamics studies of drug-loaded P105/F127-CS/CA-DOX micelles showed that the co-delivery micelles had a strong inhibitory effect on tumors with a lower toxicity. Conclusion The co-delivery micelles are pH-sensitive and have a strong inhibitory effect on cancer with a lower toxicity on normal tissues; it is potential for co-delivery of PTX and DOX.

Clinical value of lung ultrasound in the diagnosis of neonatal infectious pneumonia

YUAN Peng, LI Ya, ZHANG Feixue, WANG Qing

Journal of Shandong University (Health Sciences). 2018, 56(6):  29-34.  doi:10.6040/j.issn.1671-7554.0.2017.1239

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Objective To discuss the clinical value of lung ultrasound(LUS)in the diagnosis of neonatal infectious pneumonia(IPN). Methods The chest X-ray(CXR)and LUS results of 80 infants with IPN clinical signs and symptoms from May 2016 to Oct. 2017 were retrospectively analyzed, and the positive diagnosis rates were also comparied. The IPN infants diagnosed by LUS were followed up to observe therapeutic effects. Results The positive diagnosis rate of LUS and CXR were respective 95%(76/80)and 81%(65/80), in which 4 infants were CXR positive while LUS negative, 15 infants were CXR negative while LUS positive. Seventy-six infants were followed up with LUS, in which 40 showed a complete regression, 15 had absorptions of consolidation while with scattered or confluent B-lines, 13 had significantly reduced consolidation, 8 had no obvious changes in size of consolidation, and 4 exhibited a “lung pulse”. Conclusion LUS is of great value in diagnosis and monitor the progresses of IPN, and can be used as the preferred diagnostic method in imaging.

Applicative value of gene Xpert MTB/RIF for the rapid detection of pulmonary tuberculosis in the clinical pathway

LI Xiaofei, HUANG Shan, OUYANG Bing, YU Tingting, LIANG Guiliang, WANG Lin

Journal of Shandong University (Health Sciences). 2018, 56(6):  35-40.  doi:10.6040/j.issn.1671-7554.0.2018.152

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Objective To explore the applicative value of gene Xpert mycobacterium tuberculosis DNA and resistance to rifampicin assay(Gene Xpert MTB/RIF, shortened for Xpert)for the rapid detection of pulmonary tuberculosis in clinical practice. Methods Suspected tuberculosis inpatients admitted during Jan. 2015 and June 2017 were enrolled. Mycobacterium tuberculosis and rifampin resistance tests were performed with Xpert on the day of admission. Patients examined with Xpert were included in the experiment group(n=1 386, including patients receiving initial treatment, patients receiving retreatment and patients with multi-drug resistant tuberculosis), and those did not receive Xpert examination were involved in the control group(n=1 360, including patients receiving initial treatment, patients receiving retreatment and patients with multi-drug resistant tuberculosis). The experiment group received treatment based on the Xpert results, while the control group received routine treatment. The therapeutic effects of the two groups were compared, 山 东 大 学 学 报 (医 学 版)56卷6期 -李晓非,等.利福平耐药实时荧光定量核酸扩增技术在肺结核临床路径中的应用 \=- including hospital stay, medical costs, side effects and satisfaction from the patients and their families. Results In both of the experiment group and control group, patients with multi-drug resistant tuberculosis had longer hospital stay and higher medical costs, followed by patients receiving retreatment and then patients receiving initial treatment(P<0.001). For patients receiving initial treatment, except for the medical costs, the other three indexes were longer/higher in the experiment group than in the control group. For patients receiving retreatment, the four indexes were shorter/lower in the experiment group than in the control group. For patients with multi-drug resistant tuberculosis, except for the hospital stay, the remaining three indexes were shorter/lower in the experiment group than in the control group. Patients with abnormal liver function were detected in both groups. Rate of hepatic dysfunction among patients with multi-drug resistant tuberculosis was lower in the experiment group than in the control group, and the difference was statistically significant (χ2=18.325, P<0.001). The experiment group had higher satisfaction with the treatment process and time needed for test result report than the control group, and the differences were significant(P<0.001). In the experiment group, patients with multi-drug resistant tuberculosis and their families had higher satisfaction with the medical costs, patients’ health status and hospital stay than those in the control group (P<0.001). Some patients in the control group were strongly discontented with the medical costs. Conclusion Xpert is effective in the diagnosis and treatment of tuberculosis, especially for the early detection and treatment of multi-drug resistant tuberculosis. It can reduce the total medical costs, decrease drug abuse and side effects, shorten the hospital stay, and improve patients’ and their families’ satisfaction.

Expression and clinical significance of serum lncRNA UCA1 in esophageal squamous cell carcinoma

YAN Suzhen, DU Lutao, WANG Lili, WANG Chuanxin

Journal of Shandong University (Health Sciences). 2018, 56(6):  41-46.  doi:10.6040/j.issn.1671-7554.0.2018.178

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Objective To explore the expression of serum long non-coding RNA(lncRNA)urothelialcarcinoma associated 1(UCA1)in esophageal squamous cell carcinoma(ESCC)and its clinical significance. Methods A total of 96 ESCC cases and another 96 age-and gender-matched healthy controls were involved. The serum samples were collected to determine the expression of lncRNA UCA1 with qRT-PCR. The lncRNA UCA1 expression of 12 ESCC patients were compared before and after operation. The correlation between UCA1 expression and clinical pathological parameters of ESCC were analyzed, and the diagnostic value of serum lncRNA UCA1 was evaluated with the receiver operating characteristic curve(ROC). Results Compared with controls, ESCC patients had upregulated lncRNA UCA1 expression, which decreased after operation(P<0.001). In addition, the area under the curve(AUC)was 0.816, providing a sensitivity of 77.1% and a specificity of 76.0%. Moreover, lncRNA UCA1 was statistically superior to squamous cell carcinoma antigen(AUC=0.679)in discriminating ESCC patients from healthy controls(P<0.001). Conclusion Serum lncRNA UCA1 may serve as a potential tumor biomarker for the early diagnosis and postoperative monitoring of ESCC.

Clinical efficacy of endoscopic resection of small colorectal polyps with thermal biopsy forceps

WEI Mingyong, REN Huiling, WU Jun, PENG Xue, XIE Wenfu, ZHANG Min

Journal of Shandong University (Health Sciences). 2018, 56(6):  47-50.  doi:10.6040/j.issn.1671-7554.0.2018.011

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Objective To investigate the clinical efficacy of endoscopic resection of small colorectal polyps with thermal biopsy forceps. Methods A total of 390 patients with colorectal polyps treated during Jan. 2015 and May 2017 were selected, with 929 micro-polyps(diameter 1-10 mm)involved. The patients were divided into 2 groups according to different methods of polypectomy: thermal biopsy forceps group(n=183, 562 polyps), and argon plasma coagulation group(n=137, 367 polyps). The clinical efficacy of the 2 groups were compared. Results In the thermal biopsy forceps group, the removal rate of polyps ≤6 mm was 100%, and the effective rate for polyps <10 mm was 97.5%. In contrast, in the argon plasma coagulation group, the effective rate for polyps <10 mm was 86.6%. No perforation developed in either group. In the thermal biopsy forceps group, bleeding occurred in 1 case and slight abdominal pain in 2 cases. The incidence of postoperative complications was 1.6%. In the argon plasma coagulation group, bleeding occurred in 3 cases and abdominal pain in 5 cases. The incidence of postoperative complications was 5.8%. Conclusion Compared with traditional argon plasma coagulation, endoscopic thermal biopsy forceps is simple and effective for the resection of colorectal polyps ≤6 mm. It is worthy of wide clinical application.

Serum level of hs-CRP in patients with depression and its predictive role for the efficiency of antidepressants

WANG Dan, YANG Xiaohua, ZHENG Yunshao, KAN Weijing, XUN Guanglei

Journal of Shandong University (Health Sciences). 2018, 56(6):  51-57.  doi:10.6040/j.issn.1671-7554.0.2017.261

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Objective To explore the changes of high sensitivity C reactive protein(hs-CRP)level before and after antidepressant treatment, as well as the predictive role of hs-CRP level at baseline for the efficiency of antidepressants. Methods A total of 61 patients with depression(study group)were randomized into the sertraline subgroup(n=30)and duloxetine subgroup(n=31). At baseline and the end of 8-week treatment, the serum level of hs-CRP was measured, and Hamilton Depression Scale-17 items(HAMD-17)were evaluated. Additionally, serum hs-CRP level was measured in 32 well-matched healthy controls(control group)and re-measured 8 weeks later. Results At baseline, the serum level of hs-CRP was higher in the study group than in control group, and it decreased significantly after 8-week treatment but was still significantly higher than that in the control group at the endpoint(P<0.05). Serum hs-CRP level in the study group was positively correlated with HAMD-17 score at baseline and endpoint(P<0.05). In the duloxetine subgroup, the effective rate and reduction rate of HAMD-17 in patients with higher level of baseline hs-CRP(≥3 mg/L)were significantly higher than those in patients with lower baseline hs-CRP(<3 mg/L)(P<0.05). Moreover, in patients with higher baseline hs-CRP level, the effective rate of duloxetine was significantly higher than that of sertraline(P<0.05). Binary Logistic regression analysis indicated that baseline hs-CRP level and subgroup × baseline hs-CRP level 山 东 大 学 学 报 (医 学 版)56卷6期 -王丹,等.抑郁症患者血清hs-CRP水平变化及其对抗抑郁药疗效的预测作用 \=-entered the regression equation of efficacy. Factorial design ANOVA illustrated that interaction between antidepressant and baseline hs-CRP level had certain effects on the efficacy of treatment(P<0.05). Conclusion Elevated inflammatory response is involved in the pathophysiology of depression. Serum hs-CRP level may partly reflect the severity of depression. Depressive patients with high baseline hs-CRP level are more likely to respond to duloxetine. Validation in a larger sample is warranted.

An investigation on the psychosocial factors affecting condom use among older sex workers in Qingdao City

CAO Mingkun, XU Yiqing, LI Yifei, JIANG Zhenxia, ZHANG Xijiang, LI Xiufang, JIANG Baofa

Journal of Shandong University (Health Sciences). 2018, 56(6):  58-62.  doi:10.6040/j.issn.1671-7554.0.2017.514

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Objective To explore the psychosocial factors affecting condom use among older female sex workers(OFSWs)in Qingdao City and to provide information for departments and agencies involved to take intervention measures. Methods Totally 420 OFSWs were recruited with respondent-driven sampling method and surveyed with 山 东 大 学 学 报 (医 学 版)56卷6期 -曹明昆,等.影响青岛市大龄女性性工作者安全套使用的心理社会因素分析 \=-questionnaire during March and June 2014. Multiple linear regression and path analysis were used to analyze the psychosocial factors influencing condom use and the effects. Results Multiple linear regression showed that condom use intention(b₁=0.38)and self-efficacy(b₁=0.77)were the protective factors of condom use behavior, while the work environment(b₁=-0.12)was the risk factor. Path analysis found that perception of disease susceptibility(β2=-0.12)and negative expectation(β₂=-0.22)had indirect negative effects on condom use behavior; self-efficacy(β₂=0.56)and perception of companion use(β₂=0.13)had indirect positive effects; self-efficacy(β₂=0.66)and condom use intention(β₂=0.14)had direct positive effects. Conclusion Self-efficacy has the greatest impact on condom use among OFSWs in Qingdao City and disease control departments should improve OFSWs’ confidence in using condoms and persuading guests to use condoms.

Orientation to happiness in relation to suicide risk among medical students

YUAN Lu, LIU Yangyang, GU Lingxi, JIA Cunxian

Journal of Shandong University (Health Sciences). 2018, 56(6):  63-68.  doi:10.6040/j.issn.1671-7554.0.2018.145

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Objective To explore the association between different orientations to happiness and suicide risk of medical students. Methods Stratified by grades, a questionnaire survey of undergraduate students in Jinan, Shandong Province was conducted using clustered sampling method. The revised suicide behavior questionnaire(SBQ-R)was applied to identify suicidal risks, while the orientation to happiness(OTH)scale was recommended for measuring different orientations. Results There were 2 197 questionnaires handed out and 2 074(94.40%)questionnaires were valid. According to the total SBQ-R score(≥7), 20.64% of participants had high suicide risk. The OTH scale was divided into four groups: high meaning-high pleasure(503, 24.25%), high meaning-low pleasure(545, 26.28%), low meaning-high pleasure(662, 31.92%), and low meaning-low pleasure(364, 17.55%), with statistical differences in SBQ-R scores(F=11.736, P<0.001). After adjusting to socio-demographic variables including academic performance, single-parent families, good sleep condition as well as economic level, Logistic regression model indicated that high meaning-high pleasure(OR=0.632, 95%CI=0.449-0.887)and high meaning-low pleasure(OR=0.604, 95%CI=0.430-0.848)were negatively associated with suicide risk. Conclusion The suicide risk of medical students is relatively high and students with high meaning life appear to have low suicide risk.

Correlation analysis of treatment methods and medical expenditures of cancer patients in five counties of Shandong Province

HUA Xingxing, SUN Xiaojie, ZHAO Deli, LIU Weidong, NI Zhisong, ZOU Yuewei, MA Zhongfeng, YAO Nengliang, WANG Jialin, WANG Haipeng

Journal of Shandong University (Health Sciences). 2018, 56(6):  69-75.  doi:10.6040/j.issn.1671-7554.0.2017.506

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Objective To investigate the treatment methods and medical expenditures of cancer patients in rural areas and the relationship between them. Methods According to the geographical location and economic status, 1 003 cancer cases confirmed during 2011 and 2013 were randomly selected from five counties, including patients with breast cancer(female), lung cancer, intestinal cancer and gastric cancer. All patients were surveyed with questionnaire. Results The proportions of patients who were treated with surgery alone, surgery plus chemotherapy, traditional Chinese medicine and other treatments were 21.1%, 53.1%, 8.7% and 17.1%, respectively. The proportions of patients with medical expenditures <20 000, ≥20 000 and <50 000, ≥50 000 and <80 000 and ≥80 000 RMB were 16.3%, 47.2%, 20.8% and 15.7%, respectively. The influencing factors of medical expenditures were age, income, type of cancer, stage of disease and treatment type. Conclusion Cancer patients have to bear heavy medical expenditures, which are closely related to treatment methods. Early medical care, standardized clinical pathway and medical insurance can help to relieve patients’ financial burdens.

Comparison of multiple seasonal ARIMA model and generalized regression neural network model in forecasting the incidence of brucellosis

MA Jie, TIAN Ye, HUANG Lu, MENG Weijing, WANG Suzhen, SHI Fuyan

Journal of Shandong University (Health Sciences). 2018, 56(6):  76-82.  doi:10.6040/j.issn.1671-7554.0.2017.1185

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Objective To explore suitable model for brucellosis incidence forecasting in China, and to provide reference for forecasting warning system of brucellosis. Methods Autoregressive integrated moving average(ARIMA)model and generalized regression neural network(GRNN)model were fitted with data monthly reported by China Centers for Disease Control from January 2011 to December 2016. The monthly reported data from January to August 2017 were used to evaluate forecast results. The mean absolute error(MAE)and mean relative error(MRE)were evaluated by comparing the actual incidence with the predicted incidence of the two models. Results The MAE and MRE of the ARIMA(0,1,1)(0,1,1)₁₂model were 989, 0.23 and the GRNN model were 561, 0.14, respectively. The MAE and MRE of the GRNN model were less than the ARIMA model. Conclusion Both the ARIMA and GRNN model perform well in forecasting the incidence of brucellosis, while the prediction ability of GRNN model is slightly better than ARIMA model.

Economic order quantity model-based medicine purchasing and storing optimization

LI Xiaojing, SUN Qiang

Journal of Shandong University (Health Sciences). 2018, 56(6):  83-86.  doi:10.6040/j.issn.1671-7554.0.2017.1272

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Objective To optimize the medical purchasing process and cut down the cost of managing drugs by studying the cost and efficiency of standardized management of medicine purchasing and storing in a tertiary hospital. Methods Based on economic order quantity(EOQ)model, medical purchase information and financial data of the hospital, the optimum quantity Q₀, length of order circle L and total cost of ten kinds of randomly selected medicines TC were compared with the actual ordering quantity, ordering circle and cost. Results Length of order circle of the 10 kinds of medicines was 14.6 weeks, much longer than the actual ordering circle(1-2 weeks). Q₀ was higher than the actual ordering quantity, and the total management cost would be reduced if Q₀ was used. Conclusion Ordering frequency, human resource cost and the cost of medicine management would be significantly reduced if EOQ model is introduced based on the actuality of the hospital.

Herpes zoster following lumbar spine surgery: a report of 3 cases and literature review

WANG Peng, GONG Weiming, ZHANG Zuchang, SONG Hongliang, NING Bin, ZHAO Kai, ZHONG Jiangbo

Journal of Shandong University (Health Sciences). 2018, 56(6):  91-94.  doi:10.6040/j.issn.1671-7554.0.2018.036

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Objective To improve the prevention, diagnosis and treatment of herpes zoster after lumbar spine surgery. Methods The clinical data of 3 cases of herpes zoster following lumbar spine surgery treated during Mar. 2015 and Sep. 2017 were retrospectively analyzed. Results The patients developed herpes zoster 6, 8 and 28 days after lumbar spine surgery, respectively. After antiviral, anti-infection and other support therapies, the symptoms were relieved. Conclusion Varicella-zoster virus can be reactivated by surgery or trauma. Early recognition and timely therapeutic intervention are essential to avoid postherpetic neuralgia, neuropathic pain and other related sequelae.