Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (8): 93-100.doi: 10.6040/j.issn.1671-7554.0.2024.0659

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Correlation of triglycride-glucose index and atherosclerotic stenosis in intracranial arteries

LIU Lin1,2,3, WANG Xiaonan4, YANG Yaxi1,2,3, WANG Jiangteng1,2,3, LI Xu1,2,3, ZHOU Xinli1,2,3, GUAN Qingbo1,2,3, ZHANG Xu1,2,3   

  1. 1. Key Laboratory of Endocrine Glucose &
    Lipids Metabolism and Brain Aging, Ministry of Education;
    Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    2. Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan 250021, Shandong, China;
    3. Shandong Institute of Endocrine and Metabolic Diseases, Jinan 250021, Shandong, China;
    4. Department of Endocrinology and Nephrology, Boxing County Peoples Hospital, Boxing 256500, Shandong, China
  • Published:2024-09-20

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Abstract: Objective To investigate the association between the triglyceride-glucose(TyG)index and intracranial atherosclerotic stenosis(ICAS)in patients with acute ischaemic stroke(AIS). and to assess the value of the application of TyG index in predicting the occurrence of ICAS in AIS patients. Methods A total of 380 patients with AIS admitted to the Department of Neurology, Shandong Provincial Hospital from December 2021 to December 2023 were selected. They were divided into control group(n=116)and stenosis group(n=264)according to the results of digital subtraction angiography(DSA). Baseline data such as medical history, height, body weight, blood pressure, etc., were collected from both groups. Indices such as triglycerides(TG), fasting plasma glucose(FPG), low-density lipoprotein cholesterol(LDL-c), high-density lipoprotein cholesterol(HDL-c)and total cholesterol(TC)were measured. Multifactorial Logistic regression was used to analyse the risk factors for ICAS in AIS patients. The predictive value of the TyG index for the occurrence of ICAS in patients with AIS was assessed using the receiver operating characteristic(ROC)curve. Results History of hypertension, history of diabetes mellitus, systolic blood pressure, diastolic blood pressure, BMl, TG, FPG and TyG index were increased in the stenosis group compared with the control group, and the difference was statistically significant(P<0.05).The detection rate of ICAS in patients with AIS increased with the increase in tertile of TyG index(P<0.05). Spearmans correlation analysis showed that ICAS and history of hypertension, history of diabetes mellitus, systolic blood pressure, diastolic blood pressure, BMl, FPG, TG and TyG index were positively correlated(r values were 0.189,0.273,0.157,0.175,0.142,0.400,0.290 and 0.431, respectively, P<0.05), while ICAS and HDL-c was negatively correlated(r=-0.248, P<0.05). Two-category Logistic regression analysis showed that TyG index had an independent influence on ICAS(OR=10.829, 95%CI: 5.179-22.641, P<0.05), and HDL-c(OR=0.269,95%CI: 0.141-0.514, P<0.05)was a protective factor against ICAS. The ROC curve showed that, the area under the curve of TyG index was 0.777(95%CI: 0.723-0.830, P<0.05), which corresponded to a sensitivity of 0.811 and a specificity of 0.629 when the optimal cut-off value of TyG index was 8.625. Conclusion TyG index is associated with ICAS in AIS patients, and high TyG index may be an independent risk factor for ICAS in AIS patients.TyG index has some predictive value for ICAS in AIS patients.

Key words: Intracranial artery stenosis, Ischaemic stroke, Insulin resistance, Triglyceride-glucose index

CLC Number: 

  • R58
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