Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (10): 114-118.doi: 10.6040/j.issn.1671-7554.0.2018.789

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Impacts of leptin resistance developed in boyhood on the health condition of young adults

WANG Min1, WANG Chunhua1, LIU Hongli1, HE Zhiliang2, CUI Weiwei1, WANG Lei3, LIU Jiejun1   

  1. 1. Department of General Medicine;
    2. Department of Image;
    3. Department of Cardiology, Dezhou Peoples Hospital, Dezhou 253014, Shandong, China
  • Received:2018-07-03 Published:2022-09-27

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Abstract: Objective To investigate the impacts of leptin resistance(LR)developed in boyhood on the health condition of young adults. Methods Subjects of a previous study conducted by us 19 years ago on the relationship between serum leptin level and early onset obesity were followed up. LR group included 9 subjects who had LR in their childhood. The normal control(NC)group consisted of 28 adults randomly selected from people with normal body mass index who came for health examination in our hospital during the same period. The control group was of the same age as LR group. Height, weight, waist circumference, blood pressure, fasting blood insulin(FINS), glucose, blood lipids, liver and kidney functions were examined in both groups. The visceral fat was determined and parents’ histories of diseases were collected in LR group. The incidence of metabolic diseases such as obesity and hypertension was compared between the two groups. Results In the LR group, the incidence of central obesity(waist circumference ≥90 cm)was 100%, visceral fat area was(209.79±55.46)cm2, index of insulin resistance(HOMA IR)was 9.42±8.00 and first-degree relatives incidence of type 2 diabetes was 100%. The systolic and diastolic pressures were significantly higher in LR group than in NC group(P=0.001 1, P=0.000 5, respectively). The levels of FBG, triglyceride(TG)and uric 山 东 大 学 学 报 (医 学 版)56卷10期 -王敏,等.男性儿童瘦素抵抗对成年后健康状况的影响 \=-acid(UA)were significantly higher in LR group than in NC group(P=0.005 0, P=0.029 8, P<0.001). The levels of glutamic-pyruvic transaminase(ALT), glutamic oxalacetic transaminase(AST)and glutamyltranspeptidase(GGT)were significantly higher in LR group than in NC group (P=0.003 1, P=0.027 1, P<0.001). The incidence of fatty liver was significantly higher in LR group than in NC group(P<0.001). Conclusion Boys with early onset obesity and LR tend to develop severe obesity and insulin resistance when they grow up. Besides, they have high risks of type 2 diabetes, dyslipidemia, cancer and liver dysfunction. LR in children can predict the risk of type 2 diabetes in the first-degree relatives.

Key words: Leptin resistance, Obesity, Insulin resistance, Male

CLC Number: 

  • R589.2
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