Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 38-42.doi: 10.6040/j.issn.1671-7554.0.2018.006

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Clinical diagnosis of multiple morphological abnormalities of the sperm flagella

YANG Shenmin1, ZHANG Feng2, LI Zheng3   

  1. 1. Center for Reproduction and Genetics, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215002, Jiangsu, China;
    2. Institute of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China;
    3. Department of Andrology, Urologic Medical Center, Shanghai General Hospital, Shanghai Key Lab of Reproductive Medicine, Shanghai Jiao Tong University, Shanghai 200080, China
  • Published:2022-09-27

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Abstract: Multiple morphological abnormalities of the sperm flagella(MMAF)are severe deformity of the sperm flagella. In patients with typical MMAF, the sperm tails are absent, short, curled, bent and irregular, leading to severe 山 东 大 学 学 报 (医 学 版)56卷4期 -杨慎敏,等.精子鞭毛多发形态异常的临床诊断 \=-impaired sperm motility. Under the transmission electron microscope, the defects of the central microtubule, disorders of fibrous sheath and outer dense fibrous, and absence of dynein arms appear in the transverse section of the flagellum. The genetic causes of MMAF have not been completely disclosed yet and remain the focus of clinical and translational research. Nowadays, there are still no standards and procedures for the clinical diagnosis of MMAF. In this review, we will focus on the diagnostic strategies of MMAF in order to provide a reference for its clinical diagnosis and treatment.

Key words: Multiple morphological abnormalities of the sperm flagella, Ultrastructure, Male infertility, Clinical diagnosis

CLC Number: 

  • R698+2
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