Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (9): 48-53.doi: 10.6040/j.issn.1671-7554.0.2019.527

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Association between preoperative oral polysaccharide solution and insulin resistance in patients with colorectal cancer

WU Chengwei, SUN Boshi, ZHOU Junde, JIANG Tianming, CHI Qiang   

  1. Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang, China
  • Published:2022-09-27

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Abstract: Objective To explore the safety, feasibility and advantages of preoperative oral polysaccharide solution by comparing postoperative insulin resistance and complications between preoperative oral polysaccharide solution and placebo for patients undertaking elective colorectal surgery. Methods The clinical data of 80 patients with colorectal cancer treated during Apr. 2017 and Dec. 2018 were retrospectively analyzed, including 40 patients in the polysaccharide solution group and 40 in the control group(placebo group). The general data, homeostasis model assessment-2 insulin resistance index(HOMA2-IR), homeostasis model assessment-2 insulin sensitivity index(HOMA2-%S), fasting plasma glucose(FPG), fasting insulin(FINS), white blood cell count(WBC), C-reactive protein(CRP), procalcitonin(PCT), and postoperative complications were compared between the two groups. Results (1) There were no statistical differences in the general data between the two groups and no aspiration occurred during operation. (2) The FPG, FINS and HOMA2-IR of both groups increased after operation, while HOMA2-%S decreased(P<0.05). (3) The polysaccharide solution group had lower FPS, FINS and HOMA2-IR but higher HOMA2-%S on the 1st and 3rd postoperative day(POD1, POD3)than the control group(P<0.05). (4) The polysaccharide solution group had lower postoperative WBC 山 东 大 学 学 报 (医 学 版)57卷9期 -吴成威,等.术前口服多糖溶液对结直肠癌患者术后胰岛素抵抗的关联性研究 \=-and CRP(P<0.05). (5) The polysaccharide solution group had shorter first anus exhausting time(P<0.05). (6) There were no significant differences in postoperative infectious complications, length of stay(LOS)and hospitalization costs between the two groups(P>0.05). Conclusion Compared with the placebo, preoperative oral polysaccharide solution does not increase the risk of aspiration. Instead, it significantly reduces insulin resistance, increases insulin sensitivity, and promotes the recovery of intestinal function. However, there are no significant differences in the length of stay, hospitalization costs and complications between the usage of placebo and polysaccharide solution.

Key words: Polysaccharide solution, Carbohydrate, Colorectal cancer, Insulin resistance, Complications

CLC Number: 

  • R656
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