Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (3): 64-70.doi: 10.6040/j.issn.1671-7554.0.2021.0875

Previous Articles    

Preliminary observation of perioperative whey protein supplementation for the prevention of postoperative complications in 33 patients with esophageal cancer

WANG Yanlig1, FENG Ye2, ZHOU Xiugeng2, YANG Yue2, WU Nan2, FANG Yu1, YAN Shi2, LI Shaolei2, LYU Chao2, HAN Chao2, DU Songtao2   

  1. 1. Department of Nutrition;
    2. Department of Thoracic Surgery, Beijing Cancer Hospital &
    Beijing Institute for Cancer Research, Beijing 100142, China
  • Published:2022-03-09

PDF (PC)

68

Abstract: Objective To investigate the effects of whey protein on the postoperative complications and nutritional status of patients with esophageal cancer. Methods Patients with esophageal squamous cell cancer who underwent elective surgery during April 2017 and June 2018 were enrolled and randomly divided into observation group and control group at a ratio of 1:1. Nutritional risk screening 2002(NRS2002), Patient-Generated Subjective Global Assessments(PG-SGA)and composition measurement were used to screen and evaluate the nutritional status before operation, one day before operation and one month after operation. All patients were given basic nutritional support. In addition, whey protein powder was given to the observation group, and the intervention was continued until 1 month after surgery. The incidence of complications(above grade 2 complications including lung infection, respiratory tract infection, anastomotic leakage)was compared one month after surgery; the differences in nutritional status were compared at baseline, one day before surgery and one month after surgery. Results The incidence of complications was 24% in the observation group and 49% in the control group(P<0.05). There were no differences in the other indicators. Conclusion Preoperative whey protein supplementation combined with enteral nutrition can effectively reduce the incidence of infectious complications in patients with esophageal cancer one month after surgery. However, our sample size is small and the research results need to be further verified.

Key words: Esophageal cancer, Whey protein, Enteral nutrition, Complications

CLC Number: 

  • R735.1
[1] Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2018, 68(6): 394-424.
[2] Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014 [J]. Chin J Cancer Res, 2018, 30(1): 1-12.
[3] Gannon JA, Guinan EM, Doyle SL, et al. Reduced fitness and physical functioning are long-term sequelae after curative treatment for esophageal cancer: a matched control study [J]. Dis Esophagus, 2017, 30(8): 1-7.
[4] Elliott JA, Doyle SL, Murphy CF, et al. Sarcopenia: prevalence, and impact on operative and oncologic outcomes in the multimodal management of locally advanced esophageal cancer [J]. Ann Surg, 2017, 266(5): 822-830.
[5] 韩东景, 赵楠, 李伟, 等.食管癌患者术前营养不足和营养风险发生率及临床营养支持现状调查[J].中华肿瘤防治杂志, 2013, 20(16): 1274-1278. HAN Dongjing, ZHAO Nan, LI Wei, et al. Occurrence rate of preoperative nutritional risk, malnutrition and the current status of clinical nutritional support of patients with esophageal cancer [J]. Chinese Journal of Cancer Prevention and Treatment, 2013, 20(16): 1274-1278.
[6] Ryan AM, Rowley SP, Healy LA, et a1. Post-oesophageetomy early enteral nutrition via a needle catheter jejunostomy: 8-year experience at a specialist unit [J]. Clin Nutr, 2006, 25(3): 386-393.
[7] Schiesser M, Kirchhoff P, Mfiller MK, et a1. The correlation of nutrition risk index, nutrition risk score, and bioimpedance analysis with postoperative complications in patients undergoing gastrointestinal surgery [J]. Surgery, 2009, 145(5): 519-526.
[8] Carli F, Zavorsky GS. Optimizing functional exercise capacity in the elderly surgical population [J]. Curr Opin Clin Nutr Metab Care, 2005, 8(1): 23-32.
[9] Minnella EM, Awasthi R, Loiselle S, et al.Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery:a randomized clinical trial [J]. JAMA Surg, 2018, 153(12): 1081-1089.
[10] Gibson RS. Principles of nutritional assessment [M]. New York: Oxford University Press, 2005.
[11] Kondrup J, Rasmussen HH, Hoc ESPEN Working Group. Nutritional risk screening(NRS 2002): a new method based on an analysis of controlled trials [J]. Clin Nutr, 2003, 22(3): 321-326.
[12] Bauer J, Capra S, Ferguson M. Use of the scored patient-generated subjective global assessment(PG-SGA)as a nutrition assessment tool in patients with cancer [J]. Eur J Clin Nutr, 2002, 56(8): 779-785.
[13] Wei Chen, MD, PhD, Hua Jiang, et al. Body composition analysis by using bioelectrical impedance in a young healthy Chinese population: methodological considerations [J]. Food Nutr Bull, 2017, 38(2): 172-181.
[14] Dindo D, Demartines N, Clavien PA. Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey [J].Ann Sury, 2004, 240(2): 205-213.
[15] Carli F, Scheede-Bergdahl C. Prehabilitation to enhance perioperative care [J]. Anesthesiol Clin, 2015, 33(1): 17-33.
[16] Low DE, Kuppusamy MK, Alderson D, et al. Benchmarking complications associated with Esophagectomy [J]. Ann Surg, 2018, 269(2): 291-298.
[17] 关毅.术前口服乳清蛋白对胃肠道肿瘤手术患者胰岛素抵抗和应激反应的影响研究[J].中国全科医学,2012,15(111):3875-3877. GUAN Yi. Effects of orally taking whey protein before operation on insulin resistance and acute phase response in patients with gastrointestinal tumors [J]. Chinese General Practice, 2012, 15(111): 3875-3877.
[18] Micke P, Beeh KM, Schlaak JF, et al. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients [J]. Eur J Clin Invest, 2015, 31(2): 171-178.
[19] Gupta C. Whey proteins: a novel source of bioceuticals [J]. Middle-East J Sci Res, 2012, 12(3): 365-375.
[20] Gillis C, Loiselle SE, Fiore JF, et al. Prehabilitation with whey protein supplementation on perioperative functional exercise capacity in patients undergoing colorectal resection for cancer: a pilot double-blinded randomized placebo-controlled trial [J]. Acad Nutr Diet, 2016, 116(5): 802-812.
[21] Madzima TA, Ormsbee MJ, Schleicher EA, et al. Effects of resistance training and protein supplementation in breast cancer survivors [J]. Med Sci Sports Exerc, 2017, 49(7): 1283-1292.
[1] ZHANG Jianping, LUO Yinger. Application progress of anticoagulant drugs in the treatment of recurrent adverse pregnancy [J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 14-19.
[2] ZOU Junyi, ZHANG Hui, ZHANG Xinjie, LI Zijia, XU Minglei, WANG Dong. Clinical experience of 110 cases of orthotopic heart transplantation [J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 86-91.
[3] ZHANG Luwen, FAN Ruixin, CHANG Ying, ZHANG Qing. Effect of microecological enteral nutrition in 43 patients with severe craniocerebral injury [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 111-116.
[4] ZHANG Xiaohong, ZHOU Yun, DU Qiuying, REN Huixin, WANG Chaoqun. Atg7-siRNA interferes with radiosensitivity of esophageal cancer ECA109 cells by regulating arginine circulation [J]. Journal of Shandong University (Health Sciences), 2021, 59(4): 28-34.
[5] LUO Yingshu, LI Bin, XU Changqin, JIANG Junmei, XU Hongwei. Evaluation of the efficacy and complications of endoscopic treatment of 240 cases of upper gastrointestinal submucosal tumors [J]. Journal of Shandong University (Health Sciences), 2021, 59(3): 74-80.
[6] LYU Longfei, LI Lin, LI Shuhai, QI Lei, LU Ming, CHENG Chuanle, TIAN Hui. Application of laparoscopic fine needle catheter jejunostomy in minimally invasive McKeown resection of esophageal cancer [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 77-81.
[7] GUO Zhihua, ZHAO Daqing, XING Yuan, WANG Wei, LIANG Leping, YANG Jing, ZHAO Qianqian. Single-stage end-to-end anastomosis in the management of severe cervical tracheal stenosis [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 72-76.
[8] LI Changda, SHI Yongjun, LIN Yanliang. Effects of 27-hydroxycholesterol and cholesterol on the proliferation of esophageal squamous cell carcinoma in nude mice and human esophageal carcinoma cells(ECA109) [J]. Journal of Shandong University (Health Sciences), 2020, 58(11): 45-52.
[9] HAN Fuyan, CHENG Shiqing, WANG Zhaobao, JU Ying. Clinical significance of preoperative red blood cell distribution width in peripheral blood of patients with esophageal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 67-72.
[10] LU Ye, CUI Huifang, CHEN Xujun, HUANG Yihua, WU Yiqun, HUANG Jianlong, CHEN Huimin, XIONG Xianjun, CHEN Minghong. Application progress of freezing technology in intervention treatment of respiratory disease and preventive treatment for the correlated complications [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 19-22.
[11] WANG Juan, ZHANG Hongtao, GAO Zhen, DI Xuemin, WANG Zeyang. Prevention and treatment of complications of abdominal tumor by radioactive seeds implantation [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 8-13.
[12] LIN Qi, ZHANG Ying, DAI Jianjian, XU Ruicai, YANG Qi, GENG Baocheng, HAN Mingyong. CT-guided 125I seed brachytherapy for superficial lymph node metastases: a report of 23 cases [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 38-44.
[13] LIANG Fei, ZHANG Wenlong, ZHANG Jun, XU Chongen, ZOU Chengwei. Relevant factors and early complications of significantly elevated enzymes after off-pump coronary artery bypass grafting [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 71-75.
[14] FANG Feifei, ZHANG Ying, LIN Qi, YUAN Yuan, DAI Jianjian, XU Ruicai, GENG Baocheng, HAN Mingyong. Clinical efficacy of CT-guided 125I seed brachytherapy in the treatment of metastatic hepatic carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 53-57.
[15] ZHANG Mingming, AN Yonghui, HAN Caili, ZHANG Yingqi, MA Ming, LI Na, ZOU Changpeng. Clinical efficacy of combined cellular immunotherapy and photodynamic therapy for advanced esophageal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 38-41.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd