Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (6): 111-116.doi: 10.6040/j.issn.1671-7554.0.2020.1702

Previous Articles     Next Articles

Effect of microecological enteral nutrition in 43 patients with severe craniocerebral injury

ZHANG Luwen, FAN Ruixin, CHANG Ying, ZHANG Qing   

  1. Department of Nutrition, Peoples Hospital of Zhengzhou, Zhengzhou 450052, Henan, China
  • Published:2021-06-10

PDF (PC)

79

Abstract: Objective To investigate the effect of microecological enteral nutrition on patients with severe craniocerebral injury. Methods Eighty-five patients with severe craniocerebral injury treated in Peoples Hospital of Zhengzhou from May 2018 to June 2020 were selected and divided into control group(conventional enteral nutrition group, n= 42)and experimental group(probiotics enteral nutrition group, n= 43). The basic condition, nutritional indexes, immune function indexes and gastrointestinal complications were compared between the two groups. Results There was no significant difference in the basic condition between the two groups before treatment. However, after treatment, the values of TP, Hb, ALB, PA, GLO, IgA, IgM and IgG were increased in both groups, and the corresponding levels in the experimental group were higher than those in the control group(all P<0.05); the value of CD4+ increased while that of CD8+ decreased, and the incidence of gastrointestinal complications such as abdominal distension, vomiting and misinhalation showed no significant difference in either group(all P>0.05); the incidence of diarrhea in the experimental group was significantly lower than that in control group(P=0.031). Logistic regression analysis showed that ALB, PA, IgG and diarrhea were related to the effect of microecological enteral nutrition. Conclusion Microecological enteral nutrition can improve nutritional status and immune function in patients with severe craniocerebral injury.

Key words: Severe craniocerebral injury, Microecological preparation, Enteral nutrition

CLC Number: 

  • R651.15
[1] 徐文婷,王银玲,李静,等. 肠内加肠外营养对重症颅脑损伤患者营养状态及免疫功能的影响[J]. 郑州大学学报(医学版), 2019, 54(5): 708-711. XU Wenting, WANG Yinling, LI Jing, et al. Effects of enteral and parenteral nutrition on nutritional status and immune function of patients with severe traumatic brain injury [J]. Journal of Zhengzhou University(Medical Sciences), 2019, 54(5): 708-711.
[2] Singh AK, Jena RK, Pal R, et al. Morbidity audit of 704 traumatic brain injury cases in a dedicated South Indian Trauma Center[J]. Asian J Neurosurg, 2018, 13(3): 714-720.
[3] Bodnar CN, Morganti JM, Bachstetter AD. Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism[J]. Neural Regen Res, 2018, 13(10): 1693-1704.
[4] Peker KD, Ozkanli SS, Akyuz C, et al. Preoperative immunonutrition regulates tumor infiltrative lymphocytes and increases tumor angiogenesis in gastric cancer patients[J]. Arch Med Sci, 2017, 13(6): 1365-1372.
[5] Sioson MS, Martindale R, Abayadeera A, et al. Nutrition therapy for critically ill patients across the Asia-Pacific and Middle East regions: a consensus statement[J]. Clin Nutr ESPEN, 2018, 24: 156-164. doi: 10.1016/j.clnesp.2017.11.008.
[6] 杨磊,吴伟,王沪旭,等.益生菌联合早期肠内营养对重型颅脑损伤患者临床疗效及肠道免疫水平的影响[J].中国微生态学杂志, 2017, 29(8): 924-927. YANG Lei, WU Wei, WANG Huxu, et al. Influence of probiotics combined with early enteral nutrition on clinical efficacy and intestinal immune level in patients with severe craniocerebral injury[J]. Chinese Journal of Microecology, 2017, 29(8): 924-927.
[7] 朱锡德,孟凡国,张建宁.细孔钻颅微创治疗老年创伤性脑内血肿[J].山东大学学报(医学版), 2019, 57(3): 69-74. ZHU Xide, MENG Fanguo, ZHANG Jianning. Pore cranial drilling minimally invasive surgery in the treatment of traumatic cerebral hemorrhage in elderly[J]. Journal of Shandong University(Health Sciences), 2019, 57(3): 69-74.
[8] Chapple LS, Deane AM, Heyland DK, et al. Energy and protein deficits throughout hospitalization in patients admitted with a traumatic brain injury[J]. Clin Nutr, 2016, 35(6): 1315-1322.
[9] Quintard H, Ichai C. Nutritional and metabolic supplementation for the injured brain: an update[J]. Curr Opin Crit Care, 2019, 25(2):126-131.
[10] Xu J, Sun X, Xin Q, et al. Effect of immunonutrition on colorectal cancer patients undergoing surgery: a meta-analysis[J]. Int J Colorectal Dis, 2018, 33(3): 273-283.
[11] 邬莹玉,周纪东,江园,等.益生菌联合幽门后喂养对重型颅脑损伤患者营养状况及VAP的研究[J].重庆医学, 2019, 48(22): 3856-3861. WU Yingyu, ZHOU Jidong, JIANG Yuan, et al. Study on effects of probiotics combined with post pyloric feeding on nutritional status and VAP in patients with severe craniocerebral injury[J]. Chongqing Medicine, 2019, 48(22): 3856-3861.
[12] 宋蓉蓉,陶冶飞,朱春华,等.神经重症患者不同肠内营养方式对肺部感染的影响[J].中华医学杂志, 2018, 98(48): 3936-3940. SONG Rongrong, TAO Yefei, ZHU Chunhua, et al. Effects of nasogastric and percutaneous endoscopic gastrostomy tube feeding on the susceptibility of pulmonary infection in long-term coma patients with stroke or traumatic brain injury[J]. National Medical Journal of China, 2018, 98(48): 3936-3940.
[13] Araki T, Yokota H, Morita A. Pediatric traumatic brain injury: characteristic features, diagnosis, and management[J]. Neurol Med Chir(Tokyo), 2017, 57(2): 82-93.
[14] Balakrishnan B, Flynn-OBrien KT, Simpson PM, et al. Enteral nutrition initiation in children admitted to pediatric intensive care units after traumatic brain injury[J]. Neurocrit Care, 2019, 30(1): 193-200.
[15] 骆良钦,陈祥荣,李亚松,等. JNK信号通路在大鼠创伤性脑损伤后炎症反应中的作用[J]. 中华神经医学杂志, 2014, 13(12): 1233-1238. LUO Liangqin, CHEN Xiangrong, LI Yasong, et al. Effect of Jun N-terminal kinase signaling pathway on inflammatory response after traumatic brain injury in rats [J]. Chinese Journal of Neuromedicine, 2014, 13(12): 1233-1238.
[16] 许彬东,黄国忠,陈豪,等. 术前肠内营养对食管癌围手术期营养状态、免疫功能与应激反应的影响[J]. 肠外与肠内营养, 2018, 25(4): 204-208. XU Bindong, HUANG Guozhong, CHEN Hao, et al. The effects of preoperative enteral nutrition on peri-operative nutritional status, immune function and stress response in patients with esophagus cancer[J]. Parenteral & Enteral Nutrition, 2018, 25(4): 204-208.
[17] Dietrich WD, Bramlett HM. Therapeutic hypothermia and targeted temperature management for traumatic brain injury: experimental and clinical experience[J]. Brain Circ, 2017, 3(4): 186-198.
[18] Wan M, Forsythe SJ, El-Nezami H. Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges[J]. Crit Rev Food Sci Nutr, 2019, 59(20): 3320-3333.
[19] Vitetta L, Vitetta G, Hall S. Immunological tolerance and function: associations between intestinal bacteria, probiotics, prebiotics, and phages[J]. Front Immunol, 2018, 9: 2240. doi: 10.3389/fimmu.2018.02240.
[20] Weng H, Li JG, Mao Z, et al. Probiotics for preventing ventilator-associated pneumonia in mechanically ventilated patients: a Meta-analysis with trial sequential analysis[J]. Front Pharmacol, 2017, 8: 717. doi: 10.3389/fphar.2017.00717.
[21] 吴雷,彭艳. 重型颅脑损伤病人肠内营养相关性腹泻规范化处理流程的应用研究[J]. 肠外与肠内营养, 2019, 26(4): 228-232. WU Lei, PENG Yan. Application of enteral nutrition-related diarrhea standardized management process in patients with severe craniocerebral injury [J]. Parenteral & Enteral Nutrition, 2019, 26(4): 228-232.
[22] Zang RS, Zhang H, Xu Y, et al. Serum C-reactive protein, fibrinogen and D-dimer in patients with progressive cerebral infarction[J]. Transl Neurosci, 2016, 7(1): 84-88.
[23] Wan M, El-Nezami H. Targeting gut microbiota in hepatocellular carcinoma: probiotics as a novel therapy[J]. Hepatobiliary Surg Nutr, 2018, 7(1): 11-20.
[24] Schietroma M, Pessia B, Carlei F, et al. Intestinal permeability and systemic endotoxemia in patients with acute pancreatitis[J]. Ann Ital Chir, 2016, 87: 138-144.
[25] 孙丽娟,赵长海. 肠内营养联合合生元制剂预防危重症病人呼吸机相关肺炎的前瞻性随机对照研究[J]. 肠外与肠内营养, 2019, 26(3): 150-155. SUN Lijuan, ZHAO Changhai. Effect of enteral nutrition combined with synbiotics on ventilator-associated pneumonia in critically ill patients: a prospective randomized controlled study[J]. Parenteral & Enteral Nutrition, 2019, 26(3): 150-155.
[1] WANG Yanlig, FENG Ye, ZHOU Xiugeng, YANG Yue, WU Nan, FANG Yu, YAN Shi, LI Shaolei, LYU Chao, HAN Chao, DU Songtao. Preliminary observation of perioperative whey protein supplementation for the prevention of postoperative complications in 33 patients with esophageal cancer [J]. Journal of Shandong University (Health Sciences), 2022, 60(3): 64-70.
[2] HAO Xiaorui, ZHAO Changsheng. Effects of enteral and parenteral nutrition support on serum ALT, SCr and complications in patients with early severe stroke [J]. Journal of Shandong University (Health Sciences), 2019, 57(3): 80-84.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] ZHENG Min,HAO Yue-wei,LIU Xue-ping,ZHAO Ting-ting. Relationship between the HPA-2 and Kozak sequence polymorphism of platelet membrane glycoprotein and cerebral infarction[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(3): 292 -295 .
[2] ZHANG Jie,LI Zhen-hua,SUN Jin-hao,BAO Li-hua,LIU Yue-peng. Protective effects of the invariable magnetic field on oxidative injured Schwann cells[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 229 -232 .
[3] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(10): 995 .
[4] JIANG Hong-ju,LI Run-zhi, WANG Ying,XU Dong-mei,ZHANG Mei,ZHANG Yun,LI Ji-fu. Relationship between the plasma level of matrix metalloproteinase-9 and structural characteristics of plaques and percutaneous coronary intervention [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 966 -970 .
[5] WANG Shu-qin,QI Feng,WU Jian-bo,SUN Bao-zhu. Effect of calcium in ropivacaine-induced smooth muscle contraction of the aorta in rats in vitro[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(8): 773 -776 .
[6] TENG Xue-ren,ZHAO Yong-sheng,HU Guang-liang,ZHOU Lun,LI Jian-min. Characteristics of microcosmic changes following tendon allograft transplantation preserved by two methods under light microscopy and transmission electron microscopy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 945 -950 .
[7] WU Min,ZHAO Zhi-lun,WANG Jie-zhen. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(11): 1146 -1149 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(8): 828 -830 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(9): 5 -6 .
[10] NIU Rui,LIU Bo,SHAO Ming-ju,WANG Wei. mRNA expression of lunx in regional lymph nodes of non-small cell lung cancer and its correlation with prognosis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(9): 884 -885 .
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd