Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (4): 34-41.doi: 10.6040/j.issn.1671-7554.0.2018.1301

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Clinical observation of the effects of idebenone on Parkinsons disease

ZHANG Xiaotao1,2, HE Tianqi1,2, ZHU Meijia2, TANG Jiyou2, ZHAO Zhangning2, MAO Fei2, FANG Yuqing2, LIU Xiaomin2, MA Gaoting2, ZHANG Xiaoyu2, ZHANG Xiao2, WANG Min3, LI Xiuhua2   

  1. 1. Weifang Medical University, Weifang 261000, Shandong, China;
    2. Department of Neurology, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China;
    3. Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To investigate the effects of idebenone(IDE)on the motor and non-motor symptoms in patients with Parkinsons disease(PD)and to explore its neuroprotective effect. Methods A total of 200 PD patients were randomly divided into the IDE group(IDE+routine treatment)and routine group(routine treatment). The scores of Unified Parkinsons Disease Rating-III(on-stimulation), UPDRS-III(off-stimulation), Montreal Cognitive Assessment(MOCA), Pittsburgh Sleep Quality Index(PSQI), and Non-Motor Symptoms Scale for Parkinsons Disease(NMSS)were monitored before treatment and 3, 6, 9, 12, 15 and 18 months after treatment. Furthermore, changes of plasma superoxide dismutase(SOD)and uric acid were detected before treatment and 6, 12 and 18 months after treatment. Results (1) In month 3, 6, 9, 12, 15 and 18 after treatment, the score of UPDRS-III(on-stimulation)in the IDE group versus that in the routine group was 16.64±6.08 vs 16.79±6.44, 14.69±5.33 vs 15.64±6.16, 12.81±4.73 vs 14.58±5.86, 11.04±3.95 vs 13.54±5.56, 9.664±3.43 vs 12.41±5.11 and 8.471±3.09 vs 11.16±4.65, respectively. In month 3 and 6, there was no difference between the two groups (P>0.05). In month 9, 12, 15 and 18, the score was significantly lower in the IDE group than in the routine group(P<0.05). (2) In month 3, 6, 9, 12, 15 and 18 after treatment, the score of UPDRS-III(off-stimulation)in the IDE group versus that in the routine group was 23.09±8.63 vs 19.85±7.20, 21.10±7.13 vs 19.63±6.85, 19.30±6.24 vs 19.13±6.57, 17.39±5.37 vs 18.32±6.28, 15.65±4.78 vs 17.35±5.97 and 14.05±4.25 vs 16.10±5.64, respectively. In month 3, 6, 9 and 12, there was no difference between the two groups(P>0.05). In month 15 and 18, the score was significantly lower in the IDE group than in the routine group(P<0.05). (3) In month 3, 6, 9, 12, 15 and 18 after treatment, the MOCA score in the IDE group versus that in the routine group was 21.68±4.59 vs 22.13±4.64, 23.02±3.60 vs 22.69±4.23, 24.39±2.66 vs 23.40±3.69, 25.30±2.12 vs 24.20±3.18, 25.94±1.81 vs 25.17±2.66 and 24.72±2.23 vs 24.27±2.94, respectively. In month 3, 6 and 18, there was no significant difference between the two groups(P>0.05). In month 9, 12 and 15, the score was significantly higher in the IDE group than in the routine group(P<0.05). (4) In month 3, 6, 9, 12, 15 and 18 after treatment, the PSQI score in the IDE group versus that in the routine group was 6.36±4.26 vs 6.12±4.19, 5.33±3.84 vs 5.25±3.85, 4.59±3.45 vs 4.50±3.50, 3.32±2.92 vs 3.51±3.27, 2.71±2.38 vs 3.26±3.03 and 2.20±2.02 vs 3.04±2.84, respectively. In month 3, 6, 9, 12 and 15, there was no difference between the two groups(P>0.05). In month 18, the score was significantly lower in the IDE group than in the routine group(P<0.05). (5) In month 3, 6, 9, 12, 15 and 18 after treatment, the NMSS score in the IDE group versus that in the routine group was 54.6±31.87 vs 54.56±33.26, 52.01±30.11 vs 52.42±32.02, 46.84±30.76 vs 50.38±30.65, 41.20±29.60 vs 46.97±28.05, 38.77±26.67 vs 43.18±24.65, 36.63±25.39 vs 41.03±23.48, respectively. There was no significant difference between the two groups(P>0.05). (6) In month 6, 12 and 18 after treatment, the level of uric acid in the IDE group versus the routine group was(253.81±111.86)vs (217.82±103.24)μmol/L,(272.56±111.04)vs (198.90±102.36)μmol/L, and(280.12±111.09)μmol/L vs(191.97±101.81)μmol/L, respectively. The level of uric acid was significantly higher in the IDE group than in the routine group(P<0.05). (7) In month 6, 12 and 18, the SOD level in the IDE group versus that in the routine group was(154.45±39.96)vs (126.47±41.30)U/mL,(162.45±42.08)vs (119.36±39.71)U/mL, and(172.90±41.78)vs (112.17±37.17)U/mL, respectively. The SOD level was significantly higher in the IDE group than in the routine group(P<0.05). Conclusion IDE can improve the motor and non-motor symptoms in PD patients and slow down the progression of the disease. It has a certain neuroprotective effect on PD.

Key words: Parkinsons disease, Idebenone, Oxidative stress, Motor symptom, Non-motor symptom

CLC Number: 

  • R574
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