Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (1): 21-26.doi: 10.6040/j.issn.1671-7554.0.2021.1328

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Association between serum β-sheet level and coronary heart disease

XIE Jiaying1, QI Jia1,2, SONG Ming1, LI Yulin1, WANG Di1, JIA Xu1, ZHANG Wei1, ZHONG Ming1, SHANG Yuanyuan1   

  1. 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Cardiology, Zibo Central Hospital, Zibo 255000, Shandong, China
  • Published:2022-01-08

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Abstract: Objective To investigate the relationship between serum β-sheet level and coronary heart disease(CHD). Methods A total of 223 CHD patients and 56 healthy controls were recruited. Baseline information, coronary lesion-related indicators and peripheral blood samples were collected. Serum protein β-sheet level was determined with thioflavin T fluorescence. The relationship between β-sheet level and CHD was analyzed with multivariate Logistic regression. Results Serum ThT fluorescence intensity increased significantly in CHD group(P<0.05 or P<0.01). The β-sheet level was positively correlated with waist-hip ratio, age, heart rate, diastolic blood pressure, glycosylated hemoglobin(HbA1C), low density lipoprotein cholesterol(LDL-C), sodium(Na), white blood cell(WBC)and lactic dehydrogenase(LDH), as well as with the history of hypertension, smoking, diabetes, hyperlipidemia and family history of CHD(P<0.05 or P<0.01). Serum β-sheet level, sex, systolic blood pressure, triglyceride(TG), glucose(Glu)and homocysteine(Hcy)were independent risk factors for CHD(P<0.05 or P<0.01). Conclusion The serum β-sheet level increases in CHD patients, which is an independent risk factor for CHD, and independent of known risk factors such as LDL-C.

Key words: β-sheet, Coronary heart disease, Low density lipoprotein cholesterol, Atherosclerosis, Residual cardiovascular risk

CLC Number: 

  • R541.4
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