Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (11): 103-109.doi: 10.6040/j.issn.1671-7554.0.2019.322

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A Mendelian randomization study on the causal relationship between waist circumference and incidence of coronary heart disease

LIU Xinhui1,2, LI Hongkai1,2, LI Mingzhuo1,2, YU Yuanyuan1,2, SI Shucheng1,2, HOU Lei1,2, LIU Lu1,2, LI Wenchao1,2, YUAN Tonghui1,2, LI Yunxia1,2, ZHOU Yuchang1,2, XUE Fuzhong1,2   

  1. 1. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Healthcare Big Data Institute, Shandong University, Jinan 250002, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the causality between waist circumference(WC)and incidence of coronary heart disease(CHD)using 2-sample mendelian randomization(2MR). Methods Mutually independent genetic variants which were closely related to WC were chosen as instrumental variable(IV)from Genome Wide Association Study(GWAS)databases. By using odds ratio(OR)as outcome indicator, the causal relationship between WC and CHD was analyzed using 2MR methods, including Wald ratio method, inverse-variance weighted(IVW)method, mendelian randomization-Egger(MR-Egger)regression and weight median method. Results WC dataset of 232 101 Europeans and CHD dataset of 86 995 Europeans were used. Totally 39 SNPs were selected as IV. Similar effect estimations were obtained using 2MR methods, of which IVW results showed that the OR between WC and CHD was 1.531(95%CI:1.248- 山 东 大 学 学 报 (医 学 版)57卷11期 -刘新辉,等.腰围和冠心病因果关系的孟德尔随机化研究 \=-1.877;P<0.001). Besides, results of MR-Egger regression indicated that genetic pleiotropy did not bias the effect estimation(slope=0.003, P=0.768). Conclusion This large study using 2MR, shows there is a causal relationship between WC and incidence of CHD, and the risk of CHD will increase by approximately 50% when WC increases one standard deviation(SD=12.5cm).

Key words: Waist circumference, Coronary heart disease, Two-sample mendelian randomization, Causal inference

CLC Number: 

  • R541.4
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