Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (12): 109-116.doi: 10.6040/j.issn.1671-7554.0.2020.1036

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Association between serum uric acid variability and risk of coronary heart disease in Shandong Province

LIU Congcong1, CHEN Xiaolu1, SI Shucheng1, WANG Bojie1, LI Yunxia1, LI Wenchao1, YUAN Tonghui1, XUE Fuzhong1,2   

  1. 1. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Institute for Medical Dataology, Shandong University, Jinan 250012, Shandong, China
  • Published:2020-12-08

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Abstract: Objective To explore the association between serum uric acid(SUA)variability and the risk of coronary heart disease(CHD)in Shandong Province. Methods Based on the Big Data Platform of Health Care in Shandong Province, the CHD incidence cohort of people aged 30 to 80 years was constructed. The association between CHD risk and variability independent of the mean(VIM), average real variability(ARV)and coefficient of variation(CV)was analyzed with Cox proportional hazards model. Results During the median follow-up of 8.50 years, 1 931 new CHD cases were diagnosed, including 1 420 males and 511 females, with an incidence density of 10.60/1000 person-year. After age, gender, systolic blood pressure, fasting plasma glucose, body mass index, triglycerides, high-density lipoprotein, low-density lipoprotein, average uric acid level and the number of follow-up were adjusted, HR for VIM were 1.03(95%CI: 0.90-1.19, P=0.674), 1.18(95%CI: 1.03-1.35, P=0.018)and 1.32(95%CI: 1.16-1.51, P<0.001)for quartiles 2 to 4, respectively. When ARV and CV were used for SUA variability, the results were similar to those of VIM. Conclusion High levels of SUA variability are risk factors of CHD.

Key words: Uric acid, Variability, Coronary heart disease, Variability independent of the mean, Average real variability, Coefficient of variation

CLC Number: 

  • R181.2
[1] Yang G, Wang Y, Zeng Y, et al. Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010 [J]. Lancet, 2013, 381(9882): 1987-2015.
[2] 胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220.
[3] Li X, Meng X, Timofeeva M, et al. Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies [J]. BMJ, 2017, 357: 2376. doi: 10.1136/bmj.j2376.
[4] Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk [J]. N Engl J Med, 2008, 359(17): 1811-1821.
[5] Zuo T, Liu X, Jiang L, et al. Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies [J]. BMC Cardiovasc Disord, 2016, 16(1): 207.
[6] Lai X, Yang L, Legare S, et al. Dose-response relationship between serum uric acid levels and risk of incident coronary heart disease in the Dongfeng-Tongji Cohort [J]. Int J Cardiol, 2016, 224: 299-304. doi: 10.1016/j.ijcard.2016.09.035.
[7] Kim MK, Han K, Kim HS, et al. Effects of variability in blood pressure, glucose, and cholesterol concentrations, and body mass index on end-stage renal disease in the general population of Korea [J]. J Clin Med, 2019, 8(5): 755.
[8] Yoo JE, Shin DW, Han K, et al. Blood pressure variability and the risk of dementia: a nationwide cohort study [J]. Hypertension, 2020, 75(4): 982-990.
[9] Yang CP, Lin CC, Li CI, et al. Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes [J]. Cardiovasc Diabetol, 2020, 19(1): 4.
[10] Lim SS, Yang YL, Chen SC, et al. Association of variability in uric acid and future clinical outcomes of patient with coronary artery disease undergoing percutaneous coronary intervention [J]. Atherosclerosis, 2020, 297: 40-46. doi: 10.1016/j.atherosclerosis.2020.01.025.
[11] Kim JA, Kim J, Roh E, et al. Association of fasting plasma glucose variability with gestational diabetes mellitus: a nationwide population-based cohort study [J]. BMJ Open Diabetes Res Care, 2020, 8(1): e001084.
[12] Mena L, Pintos S, Queipo NV, et al. A reliable index for the prognostic significance of blood pressure variability [J]. J Hypertens, 2005, 23(3): 505-511.
[13] 周香, 施尚鹏, 曾力群, 等. 早发冠心病与晚发冠心病的危险因素及冠状动脉病变特点比较[J]. 中国循环杂志, 2017, 32(7): 638-641. ZHOU Xiang, SHI Shangpeng, ZENG Liqun, et al. Comparative study for risk factors and features in patients with premature coronary artery disease and mature coronary artery disease [J]. Chin Circul J, 2017, 32(7): 638-641.
[14] 高阅春, 何继强, 姜腾勇, 等. 冠心病患者冠状动脉病变严重程度与冠心病危险因素的相关分析[J]. 中国循环杂志, 2012, 27(3): 178-181. GAO Yuechun, HE Jiqiang, JIANG Tengyong, et al. Relationship of coronary stenosis severity with its risk factors in patients of coronary artery disease [J]. Chin Circul J, 2012, 27(3): 178-181.
[15] Grossman C, Grossman E, Goldbourt U. Uric acid variability at midlife as an independent predictor of coronary heart disease and all-cause mortality [J]. PLoS One, 2019, 14(8): e0220532.
[16] Li M, Hu X, Fan Y, et al. Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis [J]. Sci Rep, 2016, 6: 19520. doi: 10.1038/srep19520.
[17] Johnson RJ, Kang DH, Feig D, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? [J]. Hypertension, 2003, 41(6): 1183-1190.
[18] Bagnati M, Perugini C, Cau C, et al. When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid [J]. Biochemical Journal, 1999, 340(1): 143-152.
[19] Battelli MG, Bortolotti M, Polito L, et al. The role of xanthine oxidoreductase and uric acid in metabolic syndrome [J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(8): 2557-2565.
[20] Yu MA, Sánchez-Lozada LG, Johnson RJ, et al. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction [J]. J Hypertens, 2010, 28(6): 1234-1242.
[21] Maruhashi T, Hisatome I, Kihara Y, et al. Hyperuricemia and endothelial function: From molecular background to clinical perspectives [J]. Atherosclerosis, 2018, 278: 226-231. doi: 10.1016/j.atherosclerosis.
[22] Ndrepepa G. Uric acid and cardiovascular disease [J]. Clin Chim Acta, 2018, 484: 150-163. doi: 10.1016/j.cca.2018.05.046.
[23] Hu L, Hu G, Xu BP, et al. U-Shaped association of serum uric acid with all-cause and cause-specific mortality in US adults: a cohort study [J]. J Clin Endocrinol Metab, 2020, 105(1): 68.
[24] Wang YF, Li JX, Sun XS, et al. High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke [J]. J Int Med Res, 2018, 46(5): 1826-1838.
[25] Wood AM, Kaptoge S, Butterworth AS, et al. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies[J]. Lancet, 2018, 391(10129): 1513-1523.
[26] Clair C, Rigotti NA, Porneala B, et al. Association of smoking cessation and weight change with cardiovascular disease among adults with and without diabetes [J]. JAMA, 2013, 309(10): 1014-1021.
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