Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (6): 38-44.doi: 10.6040/j.issn.1671-7554.0.2021.0380

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Correlation between diabetic peripheral neuropathy and sarcopenia

ZHENG Fengjie, SONG Yuwen, SUN Aili, PAN Zhe, WANG Dianhui, LOU Nengjun, LYU Li, ZHUANG Xianghua, CHEN Shihong   

  1. Department of Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China
  • Published:2021-06-10

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Abstract: Objective To investigate the relationship between diabetic peripheral neuropathy(DPN)and sarcopenia in patients with type 2 diabetes mellitus(T2DM). Methods A total of 166 patients with T2DM were selected and divided into sarcopenia group(n=62)and non-sarcopenia group(n=104)according to the skeletal muscle mass index, grip strength and gait speed. Patients with symptoms or signs of DPN and a decrease in nerve conduction were diagnosed as diabetic peripheral neuropathy. Single factor analysis and multivariate Logistic regression analysis were used for statistical processing to compare the differences of clinical characteristics, biochemical indicators and prevalence of diabetic peripheral neuropathy between the two groups. Results The patients in sarcopenia group were older, but the body mass index, alanine aminotransferase level, skeletal muscle mass index, grip strength, and gait speed were lower than those in the non-sarcopenia group(P<0.05). The proportion of DPN and osteoporosis in the sarcopenia group were 83.87% and 70.97%, respectively, which were higher than those in the non-sarcopenia group(P<0.05). Male sex(OR=0.025, 95%CI: 0.004-0.143)and DPN(OR=32.927, 95%CI: 6.169-175.742)were independent risk factors for sarcopenia. Higher body mass index was a protective factor for sarcopenia(OR=0.546, 95%CI: 0.420-0.710). Conclusion DPN is an independent risk factor for sarcopenia in patients with T2DM. For patients with DPN, clinical screening for sarcopenia is recommended.

Key words: Sarcopenia, Diabetic peripheral neuropathy, Type 2 diabetes mellitus, Skeletal muscle mass index, Body mass index

CLC Number: 

  • R589
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