Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (6): 45-50.doi: 10.6040/j.issn.1671-7554.0.2021.0377

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Changes of serum IL-31 and IL-33 levels in postmenopausal patients with osteoporosis

DU Jiaojiao1, ZHUANG Xianghua1, CHEN Shihong1, WANG Xuemeng2,3, JIANG Dongqing1, WU Fei1, HAN Xiaolin2, HUA Mengyu2, SONG Yuwen1   

  1. 1. Department of Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China;
    2. The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China;
    3. Liaocheng Peoples Hospital, Liaocheng 252000, Shandong, China
  • Published:2021-06-10

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Abstract: Objective To analyze the changes of interleukin-31(IL-31)and interleukin-33(IL-33)levels in the serum of postmenopausal osteoporosis(PMOP)patients, and to explore the correlation between PMOP and IL-31/IL-33. Methods A total of 146 postmenopausal women were selected and their bone density was detected with double-energy X-ray absorptiometry(DXA). According to the bone density, the patients were divided into three groups: normal group, low bone mass group and osteoporosis group. Calcium(Ca), phosphorus(P), parathyroid hormone(PTH), 25-hydroxyvitamin D(［25(OH)D］), IL-31, IL-33, bone-specific alkaline phosphatase(BALP), type 1 procollagen N-terminal propeptide(P1NP), anti-tartrate acid phosphatase(TRACP-5b), and β-cross linked C-telopeptide of type 1 collagen(β-CTX)were evaluated. The differences in IL-31, IL-33 and bone turnover markers among the three groups were compared. Results In the three groups, the level of IL-31 showed an upward trend with the decrease of bone density, while the level of IL-33 reduced with the decrease of bone density(P<0.05). Multivariate Logistic regression analysis showed that in the low bone mass group, IL-33(OR: 0.987, 95%CI: 0.974-0.999, P=0.030)was statistically significant, while in the osteoporosis group, IL-31(OR: 1.019, 95%CI: 1.009-1.028, P<0.001)and IL-33(OR: 0.978, 95%CI: 0.960-0.995, P=0.013)were statistically significant. The OR value of IL-33 showed a downward trend with the decrease of bone mineral density, indicating that IL-31 and IL-33 were possible influencing factors of PMOP. Conclusion IL-31 is a possible risk factor for PMOP, while IL-33 is a possible protective factor for PMOP, suggesting that IL-31 and IL-33 play an important role in the pathogenesis of PMOP.

Key words: Postmenopausal osteoporosis, Interleukin-31, Interleukin-33, Bone mineral density, Bone turnover markers

CLC Number: 

  • R574
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