Abstract: Objective To analyze the expressions of type 1 collagen cross-linked C-telopeptide(β-CTX)and N-terminal propeptide of type 1 precollagen(PINP)in osteoporosis patients with subclinical hypothyroidism, and to investigate whether these bone turnover markers(BTMs)can be used as predictors of the degree of osteoporosis and the risk of brittle fracture. Methods A total of 62 patients of osteoporosis with subclinical hypothyroidism admitted during July 2016 and June 2019 were selected as the research subjects, 65 patients of osteoporosis with ostalgia admitted at the same period were enrolled as the ostalgia group, and 68 healthy people who received physical examination during the same period served as healthy controls. Bone metabolism markers including calcium, phosphorus, magnesium, alkaline phosphatase, 25 hydroxyvitamin D, bone mineral density, T value, thyroid hormone, parathyroid hormone and serum PINP 山 东 大 学 学 报 (医 学 版)58卷5期 -康成为,等.合并亚临床型甲状腺功能减退的骨质疏松症62例患者骨代谢及骨转换标志物水平分析 \=-and β-CTX levels were compared among the three groups. Results There were no significant differences in the levels of serum calcium, phosphorus, magnesium, alkaline phosphatase and parathyroid hormone among the three groups(all P>0.05)while significant differences in 25 hydroxyvitamin D, bone mineral density, T value, β-CTX and PINP levels were detected(all P<0.05). Conclusion The levels of PINP and β-CTX decreased in osteoporosis patients with subclinical hypothyroidism. Such cases are low conversion osteoporosis, and BTMs cannot be used to evaluate the degree of osteoporosis or predict the risk of fracture.

Key words: Osteoporosis, Subclinical hypothyroidism, Bone mineral density, Bone turnover markers, N-terminal propeptide of type 1 precollagen, Type 1 collagen cross-linked C-telopeptide