Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (5): 77-81.doi: 10.6040/j.issn.1671-7554.0.2019.1453

Previous Articles    

A retrospective clinical analysis of 127 cases with cerebral vein sinus thrombosis

LI Haiyun1, QIAO Shan2, CUI Caisan1   

  1. 1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China
  • Published:2022-09-27

PDF (PC)

117

Abstract: Objective To elucidate the inducing factors, clinical manifestations, imaging features, treatment and prognosis of patients with cerebral vein sinus thrombosis(CVST). Methods Clinical data of 127 CVST cases treated in Qilu Hospital of Shandong University during Feb. 2012 and Apr. 2019 were retrospectively analyzed. Results (1) Inducing factors and clinical manifestations: 43 cases(33.86%)had no explicit inducing factors, and 84 cases(66.14%)had common etiologies. Headache was the initial symptom in 97 cases(76.38%). Other common concomitant symptoms included nausea and vomiting in 78 cases(61.42%), optic nipple edema in 30 cases(23.62%), hemiplegia in 28 cases(22.05%), and seizures in 26 cases(20.47%). (2) Laboratory results: 82 patients underwent lumbar puncture, the cerebrospinal fluid pressure ranging from 70 to 330 mmH2O. The cerebrospinal fluid pressure was 200-300 mmH2O in 23 cases(28.05%), and ≥300 mmH2O in 49 cases(59.76%). (3) Imaging results: all patients underwent head CTV, MRV, and/or DSA. The lesions involved transverse sinus in 103 cases(81.10%), sigmoid sinus in 87 cases(68.50%), superior sagittal sinus in 77 cases(60.63%), straight sinus in 29 cases(22.83%), and torcular in 10 cases(7.87%). (4) Treatment and diagnosis: 2 patients complicated with cerebral hernia were discharged automatically, and the other 125 patients had significantly improved clinical symptoms and good prognosis. Conclusion The diagnostic accuracy of CVST can be improved by combining laboratory and imaging examinations, inducing factors and symptoms. Early anticoagulant therapy can effectively improve the prognosis of patients.

Key words: Cerebral vein sinus thrombosis, Clinical manifestation, Imaging, Treatment and prognosis

CLC Number: 

  • R743.9
[1] 中华医学会神经病学分会. 中国颅内静脉系统血栓形成诊断和治疗指南2015[J]. 中华神经科杂志, 2015, 48(10): 819-829.
[2] Liang ZW, Gao WL, Feng LM. Clinical characteristics and prognosis of cerebral venous thrombosis in Chinese women during pregnancy and puerperium [J]. Sci Rep, 2017, 7: 43866. doi: 10.1038/srep43866.
[3] Duman T, Uluduz D, Midi I, et al. A multicenter study of 1144 patients with cerebral venous thrombosis: The VENOST Study [J]. J Stroke Cerebrovasc Dis, 2017, 26(8): 1848-1857.
[4] Ferro JM, Canhão P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis(ISCVT)[J]. Stroke, 2004, 35(3): 664-670.
[5] Ferro JM, Canhão P. Cerebral venous sinus thrombosis: Update on diagnosis and management [J]. Curr Cardiol Rep, 2014,16(9): 523.
[6] Shimizu Y, Tsuchiya K, Fujisawa H. Deep venous thrombosis with decreased cerebral blood flow to the thalamus was completely restored by factor Xa inhibitor [J]. J Stroke Cerebrovasc Dis, 2019, 28(5): e39-e43.
[7] Tatlisumak T, Jood K, Putaala J. Cerebral venous thrombosis: epidemiology in change [J]. Stroke, 2016, 47(9): 2169-2170.
[8] Daif A, Awada A, al-Rajeh S, et al. Cerebral venous thrombosis in adults: a study of 40 cases from Saudi Arabia [J]. Stroke, 1995, 26(7): 1193-1195.
[9] Hiltunen S, Putaala J, Haapaniemi E, et al. Long-term outcome after cerebral venous thrombosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients [J]. J Neurol, 2016, 263(3): 477-484.
[10] Kaaniche F, Chaari A, Turki O, et al. Post-trauma cerebral thrombophlebitis revealed by psychiatric disorders [J]. J Mal Vasc,2015, 40(3): 192-195.
[11] Coutinho JM, Gerritsma JJ, Zuurbier SM, et al. Isolated cortical vein thrombosis: systematic review of case reports and case series [J]. Stroke, 2014, 45(6): 1836-1838.
[12] Karadas S, Milanlioglu A, Gönüllü H, et al. Cerebral venous sinus thrombosis presentation in emergency department in Van, Turkey [J]. J Pak Med Assoc, 2014, 64(4): 370-374.
[13] 余剑, 曾进胜. 重视颅内静脉系统血栓形成的诊断和治疗[J]. 中华神经科杂志, 2015, 48(10): 817-818. YU Jian, ZENG Jinsheng. Pay attention to the diagnosis and treatment of cerebral venous sinus thrombosis [J]. Chinese Journal of neurology, 2015, 48(10): 817-818.
[14] 白琳, 代允义, 李志强, 等. 孕产妇合并颅内静脉窦血栓形成的临床特征及治疗对策[J]. 中国计划生育和妇产科, 2016, 8(7): 12-15. BAI Lin, DAI Yunyi, LI Zhiqiang, et al. Clinical characteristics and treatments of intracranial venous sinus thrombosis in pregnant and pregnant women [J]. Chinese Journal of Family Planning & Gynecotokology, 2016, 8(7): 12-15.
[15] Narayan D, Kaul S, Ravishankar K, et al. Risk factors, clinical profile, and long-term outcome of 428 patients of cerebral sinus venous thrombosis: Insights from Nizams institute venous stroke registry, Hyderabad(India)[J]. Neurol India, 2012, 60(2): 154-159.
[16] Weimar C, Masuhr F, Hajjar K. Diagnosis and treatment of cerebral venous thrombosis [J]. Expert Rev Cardiovasc Ther, 2012, 10(12): 1545-1553.
[17] Sha DJ, Qian J, Gu SS, et al. Cerebral venous sinus thrombosis complicated by seizures: a retrospective analysis of 69 cases [J]. J Thromb Thrombolysis, 2018, 45(1): 186-191.
[18] Kashkoush AI, Ma H, Agarwal N, et al. Cerebral venous sinus thrombosis in pregnancy and puerperium: A pooled, systematic review [J]. J Clin Neuro Sci, 2017, 39: 9-15.
[19] Cohen JE, Boitsova S, Itshayek E. Cerebral venous sinus thrombosis [J]. Isr Med Assoc J, 2009, 11(11): 685-688.
[20] Medel R, Monteith SJ, Crowley RW, et al. A review of therapeutic strategies for the management of cerebral venous sinus thrombosis [J]. Neurosurg Focus, 2009, 27(5): E6.
[21] Behrouzi R, Punter M. Diagnosis and management of cerebral venous thrombosis [J]. Clin Med(Lond), 2018, 18(1): 75-79.
[22] Khan M, Wasay M. New oral anticoagulants(noacs)for cerebral venous thrombosis [J]. Pak J Neurol Sci, 2017, 12(4): 3-4.
[23] Rao SK, Ibrahim M, Hanni CM, et al. Apixaban for the treatment of cerebral venous thrombosis: A case series [J]. J Neurol Sci, 2017, 381: 318-320. doi: 10.1016/j.jns.2017.09.007.
[24] Al-Sulaiman A. Clinical aspects, diagnosis and management of cerebral vein and dural sinus thrombosis: A literature review [J]. Saudi J Med Med Sci, 2019, 7(3): 137-145.
[25] Thammishetti V, Dharanipragada S, Basu D, et al. A prospective study of the clinical profile, outcome and evaluation of D-dimer in cerebral venous thrombosis [J]. J Clin Diagn Res, 2016, 10(6): OC07-10. doi: 10.7860/JCDR/2016/19114.7926.
[1] Guowei TAO,Fang WANG,Xiangyi DONG,Yaxuan XU,Linli ZHAO,Beibei HU. Diagnosis of adenomyosis using ultrasound and magnetic resonance imaging [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 56-65.
[2] SUN Haoyu, JIANG Xin, CHEN Shouzhen, QU Sifeng, SHI Benkang. Multiparametric magnetic resonance imaging combined with prostate health index in the diagnosis of prostate cancer in 142 patients within PSA grey zone [J]. Journal of Shandong University (Health Sciences), 2022, 60(6): 46-50.
[3] YANG Lizhi, SUN Xiao, SHANG Mengmeng, GUO Lu, SHI Dandan, LI Jie. C-TIRADS-based nomogram for malignant risk prediction of thyroid nodules [J]. Journal of Shandong University (Health Sciences), 2022, 60(6): 64-69.
[4] ZHAO Haiqing, LI Baomin, YANG Xiaofan, ZHANG Tong, LI Jun, ZHAO Yongheng, GAO Liang. Acute intermittent porphyria with infantile spasm: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2022, 60(6): 82-89.
[5] GONG Yu, GAO Zhen, WANG Huqing, YANG Jingwen, ZHANG Guilian, ZHAN Shuqin, ZHANG Ru, WU Haiqin. Clinical and imaging characteristics of 4 cases of secondary hypertrophic olivary degeneration [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 37-42.
[6] FENG Baomin, WANG Zhou, XU Han, LI Jiacun, YU Qiaowen, XIU Jianjun. Clinical and imaging features of 19 cases of anti-myelin oligodendrocyte glycoprotein-IgG antibody associated disorders [J]. Journal of Shandong University (Health Sciences), 2022, 60(3): 45-50.
[7] ZUO Liping, JIANG Fengyang, ZHOU Binbin, FAN Jinlei, LIANG Yongfeng, DENG Zhanhao, YU Dexin. Value of preoperative multiphase MRI for predicting microvascular invasion and early recurrence of 169 hepatocellular carcinoma [J]. Journal of Shandong University (Health Sciences), 2022, 60(3): 89-95.
[8] SONG Yufeng, NING Hao, YAO Zhigang, WU Haihu, LIU Feifan, LYU Jiaju. Clinical and imaging features of adrenal cavernous hemangioma [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 37-42.
[9] LIU Xueye, LI Qiming, TANG Hongyi, XU Qiuping, CHEN Wenqian, GUO Jing. Relationship among the volume and surface area of the temporomandibular joint condyle and the sagittal position of disc in young adults [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 117-121.
[10] ZHANG Gaorui, ZHANG Yuting, ZHAO Yuxuan, WANG Fangqing, YU Dexin. Value of MnFe2O4@CNS in the theragnostic of pancreatic cancer [J]. Journal of Shandong University (Health Sciences), 2021, 59(4): 48-55.
[11] SUN Dingqi, FU Qiang, ZHANG Hui, LIU Shuai, DIAO Tongxiang, CAO Qingwei, ZHANG Keqin. Clinical value of targeted multiparameter MRI and transrectal ultrasonography fusion prostate biopsy for the detection of PI-RADS≥3 prostate cancer [J]. Journal of Shandong University (Health Sciences), 2021, 59(4): 108-113.
[12] ZENG Rong, WU Jinxiang, ZHANG Jintao, SHANGGUAN Hong, ZHOU Shengyu, TIAN Tian, DONG Liang. Primary pulmonary angiosarcoma: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2021, 59(2): 19-25.
[13] CHAI Ran, ZHANG Xiuqin, XU Chunsheng, WANG Yin, PAN Lu, WANG Bingling, DUAN Haiping. Distribution of microplastics in drinking water in Qingdao [J]. Journal of Shandong University (Health Sciences), 2021, 59(12): 58-62.
[14] SONG Zhenzhen, SUN Xiaoling, LI Haiou, WANG Fang, ZHANG Ran, YU Dexin. Value of MRI radiomics of glioma and peritumoral edema in evaluating tumor recurrence [J]. Journal of Shandong University (Health Sciences), 2021, 59(11): 53-60.
[15] LIU Yanyan, FU Zhenmei, YU Qiaowen, SUI Yi, CHEN Jinge, GAO Jie, LIN Xiangtao, WANG Ximing, HOU Zhongyu. Observation value of neonatal cerebral fiber bundle and its effect on lateralization [J]. Journal of Shandong University (Health Sciences), 2021, 59(10): 94-100.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd