Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (3): 45-50.doi: 10.6040/j.issn.1671-7554.0.2021.1149

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Clinical and imaging features of 19 cases of anti-myelin oligodendrocyte glycoprotein-IgG antibody associated disorders

FENG Baomin1, WANG Zhou2, XU Han1, LI Jiacun1, YU Qiaowen1, XIU Jianjun1   

  1. 1. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    2. Department of Radiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China
  • Published:2022-03-09

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Abstract: Objective To investigate the clinical and imaging features of anti-myelin oligodendrocyte glycoprotein-IgG antibody associated disorders(MOGAD). Methods The clinical and imaging data of 19 MOGAD patients confirmed in Shandong Provincial Hospital Affiliated to Shandong First Medical University during Sep. 2018 and Jun. 2021 were retrospectively analyzed. Results The patients included 9 males and 10 females, with a median age of 10 years. Seven cases manifested asaquaporin4(AQP4)negative neuromyelitis optica spectrum disorder(NMOSD); 6 cases presented with acute disseminated encephalomyelitis(ADEM); 4 cases presented with encephalitis, 1 of which complicated with anti-N-methyld-aspartate receptor(NMDAR)encephalitis; 1 case presented with transverse myelitis; 1 case presented with brainstem encephalitis. Abnormal signals were detected with brain MRI in 17 cases(17/19), and the lesions could be involved in any part of the brain, presenting multifocal ill-defined T2WI hyperintensity. Spinal MRI found abnormal signals in 4 cases(4/13). Orbital MRI detected abnormal signals in 4 cases(4/9), presenting T2WI hyperintensity in optic nerves, 2 of which(2/4)showed optic crossover and optic tract. The serum MOG-IgG antibody of all patients was positive; 1 case was NMDAR antibody positive; 1 case was thyroidperoxidase antibody positive. Conclusion The MOGAD clinical phenotype is associated with age, more common in children and adolescents, and prone to relapse. Lesions can involve the optic nerves, spinal cord, intracranial and other parts. The imaging performance is varied.

Key words: Myelin oligodendrocyte glycoprotein antibody, Neuromyelitis optica spectrum disorder, Multiple sclerosis, Magnetic resonance imaging

CLC Number: 

  • R445.2
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