JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (8): 98-101.doi: 10.6040/j.issn.1671-7554.0.2013.541

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Relationships between obese population-susceptibility and gene polymorphisms of neuropeptide Y and its receptor in a region of Henan Province, China

LIU Weigang1,2, LU Yun3, LI Linlin4, LI Yunqing1, SHENG Xuewen1, YIN Lei2, ZHANG Gongyuan4, ZHAO Jingzhi2   

  1. 1. Medical Record Statistics Office, Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei, China;
    2. Hospital Office, Affiliated Hospital of Henan Province Military Region, Zhengzhou 450003, Henan, China;
    3. Department of Renal Medicine, Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei, China;
    4. Department of Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
  • Received:2013-09-05 Revised:2014-07-03 Online:2014-08-10 Published:2014-08-10

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Abstract: Objective To investigate the relationships between obese population-susceptibility and gene polymorphisms of neuropeptide Y and its receptors in a region of Henan Province, China. Methods We selected 510 inhabitants aged over 18 in a region of Henan Province by the method of random cluster sampling, and analyzed the relationships of obesity degree with genetic susceptibilities. Results The genic distributions of rs2880412 and rs2880416 had statistical differences (P<0.05). The rates of genic mutation and the distributions of genotypes showed the overall increasing trend (P<0.05). Three sites of different genotypes had relevance to the occurrence of disease. The distributions in three kinds of haplotypes, including CA, GA and GC had statistical differences between obese and non-obese groups (P<0.05). When haplotype CA was as a control, haplotypes GA and GC were relevant to obese susceptibility (P<0.05). Conclusion Gene polymorphisms of rs2880412 and rs2880416 sites are statistically relevant to obese susceptibilities. The corresponding allele C and C of them are risk factors of obesity. Haplotype-analysis showed that there are interactions in the three sites.

Key words: Haplotype, Gene polymorphisms, Obesity, Susceptibility

CLC Number: 

  • R181.2
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