Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (3): 94-98.doi: 10.6040/j.issn.1671-7554.0.2019.1405

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Expressions of miR-122 and miR-33a in patients with type 2 diabetes complicated with coronary artery disease

JIN Haiyan1, ZHANG Yan1,2, MA Xiaoli1, HAN Yu1,3, ZHAO Huichen1, LIU Yuantao1, ZHANG Yuchao1   

  1. 1. Department of Endocrinology, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China;
    2. Department of Endocrinology, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia, China;
    3. Nanyang Second General Hospital, Nanyang 473000, Henan, China
  • Online:2020-03-10 Published:2022-09-27

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Abstract: Objective To investigate the expressions and diagnostic significance of serum miR-122 and miR-33a in patients with type 2 diabetes mellitus(T2DM)complicated with coronary artery heart disease(CAD). Methods Fast bloods samples were collected from 32 healthy volunteers(NC group), 32 T2DM patients(T2DM group), 32 CAD patients(CAD group)and 32 patients with T2DM and CAD(T2DM+CAD group). The expressions of miR-122 and miR-33a were detected with real-time quantitative PCR. Specificity and sensitivity of the association between miR-122 in T2DM and CAD were evaluated with receiver operating characteristic(ROC)and area under the curve(AUC). Results Compared with the NC group, the other three groups had significantly higher expressions of miR-122(P<0.05). Compared with T2DM group, the CAD and T2DM+CAD groups had significantly higher expression of miR-122(P<0.05). The AUC of miR-122 in CAD group and T2DM+CAD group was 0.72±0.05 and 0.77±0.04, respectively. There were no significant differences in the miR-33a expression among the four groups(P>0.05). Conclusion Serum miR-122 can serve as a good diagnostic marker for T2DM complicated with CAD.

Key words: miR-122, miR-33a, Type 2 diabetes mellitus, Coronary artery heart disease

CLC Number: 

  • R574
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