JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• 无栏目 • Previous Articles     Next Articles

Effects of radix salvia miltiorrhiz on TNFαand IL1 during
cold ischemia and reperfusion injury in rat
orthotopic liver transplantation

WANG Yu1, ZHOU Jie1, JIANG Xiaoqing2
   

  1. （1. Department of Hepatobiliary Surgery； 2. Department of Anesthesia, Nanfang Hospital of
    South Medical University, Guangzhou 510515, China）
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16

PDF (PC)

189

Abstract: To investigate the effect of radix salvia miltiorrhiz on TNFαand IL1 of the donor liver during orthotopic liver transplantation. Methods40 SD male rats were randomly divided into the experimental group, the control group and the sham operation group. Perfusing and preserving solution were miltiorrhiz Ringer′s lactate solution in the experimental group and Ringer′s lactate solution without miltiorrhiz in the control group. All grafts were preserved for 5 hours and then were orthotopically transplanted. Six hours after reperfusion, the recipients were sacrificed, and the serum ALT and AST were measured. Also, changes of oxygenderived free radical level MDA and expressions of TNFαand IL1 in the liver were determined. The histopathological changes were observed under a light microscope. ResultsSerum ALT and AST levels in the experimental group were significantly lower than those in the control group after reperfusion. MDA, TNFαand IL1 levels were lower in the experimental group than those in the control group. Histopathological injury changes were not as serious as in the control group. ConclusionRadix salvia miltiorrhiz may decrease the levels of TNFαand IL1 to prevent the liver graft ischemia reperfusion injury in orthotopic liver transplantation in rats.

Key words: Radix salvia miltiorrhiz, Liver transplantation, Ischemia reperfusion injury, Rat,SpragueDawley, Tumor necrosis factoralpha, Interleukin

CLC Number: 

  • R657.3
[1] MENG Zhaotun, LI Qin, SUN Hui, WU Xinfang, SUN Wenkai, GAO Wei. Correlation between interleukin-18 single nucleotide polymorphism and susceptibility of laryngeal squamous cell carcinoma: a report of 73 cases [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 58-63.
[2] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15-23.
[3] JI Yuanyuan, BAO Jingbo, ZHAO Xu, CAO Luning, CUI Min, ZHANG Na, YU Lingzhi. IL-17F promotes the proliferation, mineralization and expressions of Runx2 and Osterix in rat osteoblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(8): 24-29.
[4] FAN Yanwei, YAN Dongxue, ZHAO You. Effects of hydrogen-rich saline for lumbar intervertebral disc degeneration in rabbits [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 38-42.
[5] LIU Qingfa, WANG Chao, SUN Qijing, GONG Xiaodan, ZHANG Caiqing. Effect of interleukin-25 on inducing the airway remodeling of asthma mice by nuocyte cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 28-33.
[6] YU Yujuan, GAO Chengjie, WANG Xiaopeng, LI Bo. Effects of parecoxibsodium on inflammatory response and its neuroprotection in patients undergoing brain tumor surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 65-68.
[7] LI Hongzhi, LIU Jing, SONG Yan, CHI Lingyi, LIU Yuguang. Role of liraglutide in the repair of spinal cord injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 1-5.
[8] DONG Xiaojing, LI Jing, ZHAO Lei, QI Mei, SUN Zeyu, WANG Hong, ZHAO Weiming. Effect of natural killer cells on the production of interleukin-22 and disease process during Chlamydia muridarum lung infection [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 19-23.
[9] MAN Qi, ZHANG An, ZHANG Yuan, FAN Mingde, MA Daoxin, WANG Chengwei. Expressions and significance of Th17 and Th22 cells in peripheral blood of patients with glioma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 55-59.
[10] TIAN Xinli, JIAO Jun, ZHANG Teng, MA Daoxin, CUI Baoxia. Expression and significance of Th22 and Th17 cells in the peripheral blood of cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(7): 43-47.
[11] BAI Jinxia, BAI Jinyun, SHI Xiuju, XU Hongwei. IL-22 protects mice from acute severe pancreatitis via STAT3 signaling pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 1-6.
[12] ZHAO Lu, SUN Junbo, WEI Guimei. MRP8 regulates expression of IL-1β in gout cell model by NF-κB signaling pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 44-47.
[13] ZHANG Rongjun, HAN Bo, GAO Ling, ZHU Mei, DING Guoyu, LIANG Yan. Effects of CD40 knockdown by siRNA on rats with experimental autoimmune myocarditis and IL-22 expression [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 36-40.
[14] TANG Mengmeng, JIN Nüwa, LIU Chuanzhen, LIU Kai, CAO Guangqing, WANG He, PANG Xinyan, WU Shuming. Effects of ethyl pyruvate in the treatment of hyperkinetic pulmonary hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 75-80.
[15] YU Lei, LI Zhen. Expression of interleukin-33 and its function in the serum of patients with cerebrovascular disease [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(4): 75-79.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd