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Relationship between expression of cyclin E and nerve infiltration and prognosis in cholangiocarcinoma

BI Xiao-feng1，DU Qi-hang2，MU Qing-ling2，ZHANG Bao-ning1   

  1. 1. Departmen of Surgical oncology, Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College；2. Department of General surgery, Shandong Provincial Hospital, Jinan 250021, Shandong, China
  • Received:2007-03-27 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
  • Contact: ZHANG Bao-ning

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Abstract: Objective: To explore the expression of cyclin E in cholangiocarcinoma and investigate the relevance of cyclin E and several clinical factors with infiltration of nerve and prognosis. Methods: The S-P immunohistochemical staining method was used to determine the expression of cyclin E in 35 cases of cholangiocarcinoma tissues, 25 cases of normal bile duct tissues beside tumor and 11 cases of bile duct′s benign disease. Results: The positive expression rate of cyclin E in cholangiocarcinoma was higher than that in infiltration of surroundings（P＜0.01） and tissues of bile duct′s benign diseases（P＞0.05）. The positive expression of cyclin E was related to infiltration of nerve（P＜0.01）, but was not related to the size of tumor, pathologyic stage, infiltration and clinical TNM stage（P＞0.05）. The median survival time was significantly longer in patients negative for the cyclin E expression than that in those positive for the expression（P＜0.01）. Conclusions: The positive expression of cyclin E is related to infiltration of nerve. cyclin E may be one of markers to evaluate the prognosis of cholangiocarcinoma.

Key words: Bile duct neoplasms, Immunohistochemistry, Cyclin E, Prognosis

CLC Number: 

  • R735.8
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