Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (10): 58-62.doi: 10.6040/j.issn.1671-7554.0.2023.0451

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A Mendelian randomization study of aspirin use and the risk of endometrial cancer

CHANG Xin1,2, LIU Shijia1,2, HAN Lu2   

  1. 1. Graduate School of Dalian Medical University, Dalian 116044, Liaoning, China;
    2. Department of Gynecology, Dalian Women and Childrens Medical Centre(Group)/ Laboratory of Early Diagnosis and Biotherapy of Malignant Tumors in Children and Women in Liaoning Province/ National Clinical Key Specialist Construction Project of Obstetrics and Gynecology, Dalian 116033, Liaoning, China
  • Published:2023-11-08

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Abstract: Objective To investigate the causal relationship between aspirin use and the risk of endometrial cancer using the two-sample Mendelian randomization method. Methods A two-sample Mendelian randomization analysis was performed to estimate the potential causal relationship between aspirin use and endometrial endometrioid carcinoma(EEC)and non-endometrioid carcinoma(NEC)using GWAS genome-wide data. The single nucleotide polymorphism(SNP)data associated with aspirin use, EEC and NEC were obtained from the GWAS catalog database. SNPs with strong association with aspirin use were selected as instrumental variables and analyzed with inverse variance weighted(IVW), weighted median, MR Egger, simple mode and weighted mode. The causal relationship between aspirin use and risk of EEC and NEC was evaluated with odds ratio(OR). Results A total of 6 SNPs were included as instrumental variables, and the IVW showed that aspirin administration reduced the incidence of EEC(OR=0.02, 95%CI: 0-0.28, P=0.005), while no causal relationship was found between aspirin use and the risk of NEC(OR=0.00, 95%CI: 0.00-16.26, P=0.199). The results of other methods were consistent with those shown by IVW. Sensitivity analysis indicated that heterogeneity, horizontal pleiotropy and leave-one-out tests showed reliability of instrumental variables in different tissue types of endometrial cancer with no significant bias in the results. Conclusion Aspirin can reduce the risk of EEC. Exploring the biological mechanism of aspirin on EEC at a deeper level has important implications for the early prevention and treatment of endometrial cancer.

Key words: Aspirin, Endometrial cancer, Endometrial endometrioid carcinoma, Mendelian randomization, Causal inference

CLC Number: 

  • R737.33
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