Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (5): 102-107.doi: 10.6040/j.issn.1671-7554.0.2023.0085

• 公共卫生与管理学 • Previous Articles    

A mendelian randomization analysis on the causal associations between amino acids and type 2 diabetes

ZHANG Tianxin1,2, ZHANG Ting3, HUANG Xin1,2, HAN Jiayi1,2, WANG Shukang1,2   

  1. 1. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Institute of Medical Dataology, Shandong University, Jinan 250002, Shandong, China;
    3. Department of Pharmacy, Shandong Public Health Clinical Center, Jinan 250102, Shandong, China
  • Published:2023-05-15

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Abstract: Objective To investigate the bidirectional causal association between amino acids and type 2 diabetes(T2D). Methods Data of genome-wide association study on amino acids and T2D were collected. Inverse variance weighted method, weighted median method, MR-Egger regression method, MR robust adjusted profile score method and MR pleiotropy residual sum and outlier method(MR-PRESSO)were adopted for two-sample bidirectional mendelian randomization(MR)analysis. Cochrans Q test, MR-Egger intercept test, and MR-PRESSO global test were used to evaluate the heterogeneity and pleiotropy of the results. Results The results of inverse variance weighted method showed that leucine(OR=1.239, 95%CI: 1.078-1.424, P=0.002 5)and valine(OR=1.222, 95%CI: 1.071-1.394, P=0.002 9)increased the risk of T2D, while glycine(OR=0.885, 95%CI: 0.831-0.942, P=0.000 1)decreased the risk. The results of reverse MR analysis showed that the risk of T2D was causally associated with increased leucine, isoleucine, valine, alanine, phenylalanine and tyrosine, and decreased glycine. The results of multiple MR methods suggested robustness of causal associations and no potential pleiotropy was found in the sensitivity analysis. Conclusion Higher levels of leucine and valine and lower level of glycine have bidirectional causal associations with T2D risk. T2D has positive causal effects on isoleucine, alanine, phenylalanine and tyrosine.

Key words: Amino acids, Type 2 diabetes, Mendelian randomization, Causal inference, Branched-chain amino acids

CLC Number: 

  • R587.1
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