Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (5): 20-24.doi: 10.6040/j.issn.1671-7554.0.2022.1164

• 临床医学 • Previous Articles    

Frequency and risk factors of muscle cramp in 136 cases of type 2 diabetes mellitus

LI Jinquan, GAO Meifang, YAN Fei, DONG Ming   

  1. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2023-05-15

Abstract: Objective To investigate the frequency of muscle cramp and analyze the risk factors in patients with type 2 diabetes mellitus(T2DM). Methods A total of 136 T2DM patients were involved and assessed with the Muscle Spasm Scale. According to the results of the scale, they were divided into muscle cramp group(n=65)and non muscle cramp group(n=71). Patients age, gender, body mass index(BMI), smoking history, alcohol consumption, mean arterial pressure(MAP), duration of diabetes, plasma glucose, glycosylated hemoglobin A1c(HbA1c), fasting C-peptide, serum albumin(ALB), serum creatinine(Scr), magnesium(Mg), total calcium(Ca)and vitamin D(VIT-D)were assessed. Risk factors of muscle cramp were screened with multivariate binary Logistic regression. Results The study revealed that47.8%(65/136)patients suffered from various degrees of muscle cramp. The ALB level of the muscle cramp group was significantly lower than that of the non muscle spasm group(P=0.023). The duration of diabetes was also significantly prolonged(P=0.045). There were no significant differences in other parameters between the two groups(P>0.05). Multivariate Logistic regression showed that increased duration of diabetes(OR=1.068, 95%CI: 1.008-1.131)and reduced ALB level(OR=1.159, 95%CI: 1.015-1.323)were independent risk factors of muscle cramp. Conclusion Decreased ALB level and extended diabetes duration may be independent risk factors for the occurrence of muscle cramp in patients with T2DM.

Key words: Type 2 diabetes mellitus, Muscle cramp, Duration of diabetes, Albumin

CLC Number: 

  • R587.1
[1] Xu D, Yang A, Ren R, et al. Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: a prospective multicenter, randomized, controlled, crossover pilot trial[J]. Nutrition, 2022, 97: 111608. doi: 10.1016/j.nut.2022.111608.
[2] Martinez-Navarro I, Montoya-Vieco A, Collado E, et al. Muscle cramping in the marathon: dehydration and electrolyte depletion vs. Muscle damage[J]. J Strength Cond Res, 2022, 36(6): 1629-1635.
[3] Li J, Li Y, Ma W, et al. Association of time in range levels with lower extremity arterial disease in patients with type 2 diabetes[J]. Diabetes Metab Syndr, 2020, 14(6): 2081-2085.
[4] Chatrath H, Liangpunsakul S, Ghabril M, et al. Prevalence and morbidity associated with muscle cramps in patients with cirrhosis[J]. Am J Med, 2012, 125(10): 1019-1025.
[5] Katzberg H, Kokokyi S, Halpern E, et al. Prevalence of muscle cramps in patients with diabetes[J]. Diabetes Care, 2014, 37(1): e17-e18.
[6] Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a who consultation[J]. Diabet Med, 1998, 15(7): 539-553.
[7] Maughan RJ, Shirreffs SM. Muscle cramping during exercise: causes, solutions, and questions remaining[J]. Sports Med, 2019, 49(Suppl 2): 115-124.
[8] Katzberg HD. Neurogenic muscle cramps[J]. J Neurol, 2015, 262(8): 1814-1821.
[9] Abraham A, Barnett C, Lovblom LE, et al. Cramps frequency and severity are correlated with small and large nerve fiber measures in type 1 diabetes[J]. Clin Neurophysiol, 2018, 129(1): 122-126.
[10] Imbe A, Tanimoto K, Inaba Y, et al. Effects of l-carnitine supplementation on the quality of life in diabetic patients with muscle cramps[J]. Endocr J, 2018, 65(5): 521-526.
[11] Restivo DA, Casabona A, Frittitta L, et al. Efficacy of botulinum toxin a for treating cramps in diabetic neuropathy[J]. Ann Neurol, 2018, 84(5): 674-682.
[12] Maxwell SK, Kokokyi S, Breiner A, et al. Characteristics of muscle cramps in patients with polyneuropathy[J]. Neuromuscul Disord, 2014, 24(8): 671-676.
[13] Katzberg HD. Case studies in management of muscle cramps[J]. Neurol Clin, 2020, 38(3): 679-696.
[14] Miwa T, Hanai T, Morino K, et al. Effect of l-carnitine supplementation on muscle cramps induced by stroke: a case report[J]. Nutrition, 2020, 71: 110638. doi: 10.1016/j.nut.2019.110638.
[15] Hawke F, Mckay MJ, Baldwin JN, et al. Correlates of night-time and exercise-associated lower limb cramps in healthy adults[J]. Muscle Nerve, 2021, 64(3): 301-308.
[16] Jang ES, Hwang SH, Kim JW, et al. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: A single-arm pilot study[J]. Yonsei Med J, 2021, 62(1): 21-28.
[17] Murata A, Hyogo H, Nonaka M, et al. Overlooked muscle cramps in patients with chronic liver disease: in relation to the prevalence of muscle cramps[J]. Eur J Gastroenterol Hepatol, 2019, 31(3): 375-381.
[18] Sawada Y, Shiraki M, Iwasa M, et al. The effects of diuretic use and the presence of ascites on muscle cramps in patients with cirrhosis: a nationwide study[J]. J Gastroenterol, 2020, 55(9): 868-876.
[19] Sawada Y, Kawaratani H, Kubo T, et al. Effect of furosemide on muscle cramps in patients with liver cirrhosis[J]. J Gastroenterol Hepatol, 2020, 35(1): 76-81.
[20] Hiraoka A, Yoshiji H, Iwasa M, et al. Clinical features of liver cirrhosis patients with muscle cramping: a multicenter study[J]. Eur J Gastroenterol Hepatol, 2019, 31(12): 1557-1562.
[21] Miwa T, Hanai T, Sakai Y, et al. Mac-2-binding protein glycosylation isomer is useful to predict muscle cramps in patients with chronic liver disease[J]. Medicine(Baltimore), 2022, 101(41): e31145. doi: 10.1097/MD.0000000000031145.
[22] Giuriato G, Pedrinolla A, Schena F, et al. Muscle cramps: comparison of the two-leading hypothesis[J]. J Electromyogr Kinesiol, 2018, 41: 89-95. doi: 10.1016/j.jelekin.2018.05.006.
[23] Bernat-Adell MD, Collado-Boira EJ, Moles-Julio P, et al. Recovery of inflammation, cardiac, and muscle damage biomarkers after running a marathon[J]. J Strength Cond Res, 2021, 35(3): 626-632.
[24] Barna O, Lohoida P, Holovchenko Y, et al. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps[J]. Nutr J, 2021, 20(1): 90. doi: 10.1186/s12937-021-00747-9.
[25] Murray D, Miller KC, Edwards JE. Does a reduction in serum sodium concentration or serum potassium concentration increase the prevalence of exercise-associated muscle cramps?[J]. J Sport Rehabil, 2016, 25(3): 301-304.
[26] Joensuu J, Mustajoki PP, Mustonen PK, et al. Prevention of leg cramps by using compression stockings or magnesium supplements in the 50-84 age group: study protocol for a randomised controlled trial[J]. Trials, 2021, 22(1): 860. doi: 10.1186/s13063-021-05753-0.
[27] Garrison SR, Korownyk CS, Kolber MR, et al. Magnesium for skeletal muscle cramps[J]. Cochrane Database Syst Rev, 2020, 9(9): CD009402. doi: 10.1002/14651858.CD009402.pub3.
[28] Barrett EJ, Liu Z, Khamaisi M, et al. Diabetic microvascular disease: an endocrine society scientific statement[J]. J Clin Endocrinol Metab, 2017, 102(12): 4343-4410.
[29] Yan F, Yuan Z, Wang N, et al. Direct activation of angiotensin Ⅱ type 2 receptors enhances muscle microvascular perfusion, oxygenation, and insulin delivery in male rats[J]. Endocrinology, 2018, 159(2): 685-695.
[30] Abd-Elsalam S, Ebrahim S, Soliman S, et al. Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study[J]. Eur J Gastroenterol Hepatol, 2020, 32(8): 1042-1045.
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