Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (11): 108-112.doi: 10.6040/j.issn.1671-7554.0.2022.0345

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Influencing factors of mild cognitive impairment in elderly patients with type 2 diabetes

YU Shujuan1,2,3, WANG Meijuan4, CHEN Li5, CAO Yingjuan1,2,4 LYU Xiaoyan1,2,6, LIU Xueyan4, LIN Peng5, YAN Jingzheng4   

  1. Shandong University 1. Department of Nursing, Qilu Hospital;
    2. Nursing Theory &
    Practice Innovation Research Center;
    3. Department of Urology, Qilu Hospital;
    4. School of Nursing and Rehabilitation;
    5. Department of Endocrinology, Qilu Hospital;
    6. International Medical Services, Qilu Hospital, Jinan 250012, Shandong, China
  • Online:2022-11-10 Published:2022-11-04

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Abstract: Objective To analyze the influencing factors of mild cognitive impairment(MCI)in elderly patients with type 2 diabetes, and to provide reference for the development of targeted intervention measures. Methods A total of 110 elderly patients with type 2 diabetes were selected with convenience sampling method during Nov. and Dec. 2021, and divided into MCI group and non-MCI group. The influencing factors of MCI were analyzed with univariate and multivariate non-conditional Logistic regression. Results Of the 110 patients, 72(65.45%)had MCI. There were statistically significant differences in age, education level, monthly family income, duration of diabetes and blood glucose before bedtime between MCI group and non-MCI group(P<0.05). Multivariate Logistic regression analysis showed that the monthly family income(OR=0.236, 95%CI: 0.096-0.581), duration of diabetes(OR=1.077, 95%CI: 1.005-1.154), and blood glucose before bedtime(OR=1.213, 95%CI: 1.030-1.428)were the influencing factors of MCI(P=0.002, P=0.036, P=0.020). Conclusion The prevalence of MCI in patients with type 2 diabetes is high. Low family monthly income, long course of diabetes and high blood glucose before bedtime may increase the risk of MCI and should arouse attention.

Key words: Elderly, Type 2 diabetes, Mild cognitive impairment, Influencing factors

CLC Number: 

  • R587.1
[1] Li Y, Teng D, Shi X, et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study [J]. BMJ, 2020, 369: m997. doi: 10.1136/bmj.m997.
[2] Jayaraj RL, Azimullah S, Beiram R. Diabetes as a risk factor for Alzheimer's disease in the middle east and its shared pathological mediators [J]. Saudi J Biol Sci, 2020, 27(2): 736-750.
[3] Jia L, Du Y, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study [J]. Lancet Public Health, 2020, 5(12): e661-e671.
[4] 中国老年型糖尿病防治临床指南编写组, 中国老年医学学会老年内分泌代谢分会, 中国老年保健医学研究会老年内分泌与代谢分会,等. 中国老年2型糖尿病防治临床指南(2022年版)[J]. 中华内科杂志, 2022, 61(1): 12-50.
[5] You Y, Liu Z, Chen Y, et al. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis [J]. Acta Diabetol, 2021, 58(6): 671-685.
[6] Tomlin A, Sinclair A. The influence of cognition on self-management of type 2 diabetes in older people [J]. Psychol Res Behav Manag, 2016, 9: 7-20. doi: 10.2147/PRBM.S36238.
[7] Kim JH, Chon D. Association between cognitive impairment, vascular disease and all-cause mortality [J]. J Nutr Health Aging, 2018, 22(7): 790-795.
[8] 中国痴呆与认知障碍诊治指南写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会. 2018中国痴呆与认知障碍诊治指南(五): 轻度认知障碍的诊断与治疗[J]. 中华医学杂志, 2018, 98(17): 1294-1301.
[9] Jia X, Wang Z, Huang F, et al. A comparison of the mini-mental state examination(MMSE)with the Montreal cognitive assessment(MoCA)for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study [J]. BMC Psychiatry, 2021, 21(1): 485. doi: 10.1186/s12888-021-03495-6.
[10] Zhuang L, Yang Y, Gao J. Cognitive assessment tools for mild cognitive impairment screening [J]. J Neurol, 2021, 268(5): 1615-1622.
[11] Kim HG. Cognitive dysfunctions in individuals with diabetes mellitus [J]. Yeungnam Univ J Med, 2019, 36(3): 183-191.
[12] You Y, Liu Z, Chen Y, et al. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis [J]. Acta diabetologica, 2021, 58(6): 671-685.
[13] Koekkoek PS, Kappelle LJ, Van Den Berg E, et al. Cognitive function in patients with diabetes mellitus: guidance for daily care [J]. Lancet Neurol, 2015, 14(3): 329-340.
[14] Santos T, Lovell J, Shiell K, et al. The impact of cognitive impairment in dementia on self-care domains in diabetes: a systematic search and narrative review [J]. Diabetes Metab Res Rev, 2018, 34(6): e3013. doi: 10.1002/dmrr.
[15] 吴越, 姚建军, 程灶火, 等. 无锡市社区老年人轻度认知功能障碍调查及其影响因素分析[J]. 现代预防医学, 2017, 44(2): 259-263. WU Yue, YAO Jianjun, CHENG Zaohuo, et al. Survey on mild cognitive impairment and analysis of its influencing factors among community elderly in Wuxi city [J]. Modern Preventive Medicine, 2017, 44(2): 259-263.
[16] 黄豪, 陈黎, 朱慧蓉, 等. 社区2型糖尿病患者健康素养状况及影响因素分析[J]. 中国初级卫生保健, 2022, 36(6): 60-61. HUANG Hao, CHEN Li, ZHU Huirong, et al. The analysis of diabetes health literacy level of type 2 diabetes mellitus and its influencing factors [J]. Chinese Primary Health Care, 2022, 36(6): 60-61.
[17] Stern Y, Barulli D. Cognitive reserve [J]. Handb Clin Neurol, 2019, 167: 181-190. doi:10.1016/B978-0-12-804766-8.00011-X.
[18] Chan MY, Na J, Agres PF, et al. Socioeconomic status moderates age-related differences in the brains functional network organization and anatomy across the adult lifespan [J]. Proc Natl Acad Sci U S A, 2018, 115(22): E5144-E5153.
[19] 黄倩, 杜蕾, 昌菁, 等. 中青年2型糖尿病患者并发轻度认知功能障碍相关影响因素研究[J]. 现代生物医学进展, 2021, 21(22): 4256-4261. HUANG Qian, DU Lei, CHANG Jing, et al. Related factors of mild cognitive impairment in young and middle-aged patients with type 2 diabetes mellitus [J]. Progress in Modern Biomedicine, 2021, 21(22): 4256-4261.
[20] 薛承浩, 郭海健, 李明码, 等. 2型糖尿病患者轻度认知功能障碍影响因素的Meta分析 [J]. 中国循证医学杂志, 2022, 22(5): 568-574. XUE Chenghao, GUO Haijian, LI Mingma, et al. Influencing factors of mild cognitive impairment in patients with type 2 diabetes: a meta-analysis [J]. Chinese Journal of Evidence-Based Medicine, 2022, 22(5): 568-574.
[21] Barbiellni Amidei C, Fayosse A, Dumurgier J, et al. Association between age at diabetes onset and subsequent risk of dementia [J]. Jama, 2021, 325(16): 1640-1649.
[22] Cuevas HE. Type 2 diabetes and cognitive dysfunction in minorities: a review of the literature [J]. Ethn Health, 2019, 24(5): 512-526.
[23] Xue M, Xu W, Ou YN, et al. Diabetes mellitus and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 144 prospective studies [J]. Ageing Res Rev, 2019, 55: 100944. doi: 10.1016/j.arr.
[24] 廖欢, 杨美兰, 颜雯, 等. 老年糖尿病患者睡前血糖波动对心律的影响分析[J]. 中国城乡企业卫生, 2017, 32(3): 99-100. LIAO Huan, YANG Meilan, YAN Wen, et al. Effect of blood glucose fluctuation on heart rhythm in elderly diabetic patients before bedtime [J]. Chinese Journal of Urban and Rural Enterprise Hygiene, 2017, 32(3): 99-100.
[25] 曹宇虎. 老年2型糖尿病患者睡前血糖与夜间低血糖相关因素分析 [J]. 中国农村卫生, 2016, 6(6): 5-6. CAO Yuhu. Analysis of factors related to blood glucose before sleep and nocturnal hypoglycemia in elderly patients with type 2 diabetes mellitus[J]. China Rural Health, 2016, 6(6): 5-6.
[26] Che T, Yan C, Tian D, et al. The association between sleep and metabolic syndrome: a systematic review and meta-analysis [J]. Front Endocrinol(Lausanne), 2021, 12: 773646. doi: 10.3389/fendo.
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