Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (11): 102-107.doi: 10.6040/j.issn.1671-7554.0.2022.0322

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Prostate clear cell adenocarcinomas: a report of 3 cases and literature review

ZHU Yongcun1, ZHAO Xiushi2, SUN Nannan3, YAO Zhigang4, ZHOU Xingchen5, MU Kun3,6   

  1. 1. Department of Pathology, Weihai Municipal Hospital, Weihai 264200, Shandong, China;
    2. Department of Pathology, Chinese Medicine Hospital of Gaomi, Gaomi 261500, Shandong, China;
    3. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    5. Department of Pathology, The Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    6. Department of Pathology, School of Basic Medical Sciences, Shandong University, Jinan 250012, Shandong, China
  • Online:2022-11-10 Published:2022-11-04

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Abstract: Objective To explore the clinicopathological features and differential diagnosis of primary clear cell adenocarcinoma(CCA)of the prostate. Methods The pathological data of 3 cases of primary prostate CCA were retrospectively analyzed and relevant literature was reviewed. Immunohistochemistry(IHC)was performed with a group of differential antibodies. Results The patients aged 29 to 54 years. The CCA was located in prostatic utricle in 2 cases and in prostatic parenchyma in 1 case. The clinical manifestation was hematospermia in 2 cases and progressive dysuria in 1 case. Microscopically, a mixture of three histological structures were observed, including glandular, papillary and solid patterns. The so-called hobnail pattern was visible in the glandular and papillary surfaces. Immunohistochemically, CK7, PAX-8, HNF-1β were positive, and AMACR, NapsinA, CA125 were partially positive. During the follow-up of 12 to 15 months, 1 patient was lost, 1 developed metastases of the lung and inguinal lymph nodes, and the other had no recurrence or metastasis. Conclusion The serum CA125 level might be elevated while prostate specific antigen(PSA)level is normal for patients with prostate CCA. Young patients with hemospermia should be altered. The diagnosis relies on histopathological examination and immunohistochemical staining. The prognosis of patients with tumor located in prostatic parenchyma is worse than that located in prostatic utricle.

Key words: Prostate, Clear cell adenocarcinoma, Diagnosis, Prognosis

CLC Number: 

  • R365
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