Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (11): 96-101.doi: 10.6040/j.issn.1671-7554.0.2022.0476

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Exploring the clinicopathological features of three cases of gastric cancer in one pedigree during short-term

MU Yanxi1, WANG Wenjie2, CHEN Kang2, YAO Yalong1, LI Jinzhou1, WEI Haoqi1, LIU Haipeng2, HUANG Zeping2, CHEN Xiao2   

  1. 1. Second Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China;
    2. Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
  • Online:2022-11-10 Published:2022-11-04

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Abstract: Objective To summarize the clinical features of familial clustered gastric cancer to provide reference for the prevention and treatment. Methods The clinical data of 3 brothers and sisters from the same family admitted during Dec. 2016 and Jan. 2022 due to gastric cancer were retrospectively collected. The general condition, clinical characteristics, treatment and outcomes were analyzed. All patients were followed up until March 2022. Results Gastric cancer was clustered in this family, including 2 males and 1 female, with an average age of 47 years at the time of onset. The 3 patients had common living and eating habits, which were in line with the diagnosis of familial clustered gastric cancer. After surgery and postoperative chemotherapy, 1 patient was deceased, and the other 2 were regularly followed up. Conclusion The incidence of familial clustered gastric cancer is relatively low. It is rare that all three siblings in the same family have gastric cancer in a short period of time. Therefore, when there are more than 2 people in the family suffering from gastric cancer, familial aggregation of gastric cancer must be alerted.

Key words: Gastric cancer, Familial aggregation, Clinicopathological features

CLC Number: 

  • R735.2
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