Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (8): 86-93.doi: 10.6040/j.issn.1671-7554.0.2022.1021

• 公共卫生与管理学 • Previous Articles    

Causal relationship between uterine leiomyomas and breast cancer: a two-sample Mendelian randomization study

ZHANG Nana1,2, ZHAO Yiming2, LIU Xinmin2   

  1. 1. Department of Gynaecology, Huzhou Hospital of Chinese Medicine, Huzhou 313000, Zhejiang, China;
    2. Department of Gynecology, Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • Published:2023-08-30

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Abstract: Objective To investigate the causal relationship between uterine leiomyomas(ULs)and breast cancer(BC). Methods The study employed a two-sample Mendelian randomization(MR)method, the European genetic data from published genome-wide association study, and ULs as exposure, single nucleotide polymorphisms(SNPs)of ULs as instrumental variables, and BC as outcome variable. In addition, 5 molecular subtypes of BC were analyzed as outcome variables. The heterogeneity of SNPs was determined with Cochrans Q test, and the pleiotropy was determined with MR-egger. Inverse variance weighted(IVW), MR-Egger, weighted median and MR-PRESSO were used to evaluate the causal relationship of ULs with BC. The R software was used for data analysis and visualization processing. Results A total of 25 SNPs of ULs were finally extracted. Cochrans Q test suggested that heterogeneity existed among some subgroups(P<0.01). No pleiotropy was observed(P>0.05). MR analysis showed that there was no causal relationship between ULs predicted by gene and overall BC(IVW: OR=0.98, 95%CI: 0.86-1.12, P=0.79), and there was no causal relationship with 5 molecular subtypes of BC(P>0.01). Conclusion There is no causal relationship between ULs and increased risk of overall BC in Europeans, and no causal relationship between ULs and any molecular subtype of BC.

Key words: Uterine leiomyomas, Breast cancer, Molecular subtype, Mendelian randomization, Causal relationship

CLC Number: 

  • R737.33
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