Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (2): 72-77.doi: 10.6040/j.issn.1671-7554.0.2022.1184

• 临床医学 • Previous Articles     Next Articles

Relationship between carotid artery stenosis and white matter structural topological properties in the elderly

WANG Shaohu1, MU Xin2, XU Chengfei3, ZHAO Yingxin1, ZHANG Hua1   

  1. 1. School of Clinical and Basic Medical Sciences, Institute of Basic Medicine, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan 250118, Shandong, China;
    2. Department of Medical Imaging Center, Third Peoples Hospital of Jinan, Jinan 250132, Shandong, China;
    3. Department of Critical Care Medicine, Tianjin Third Central Hospital, Tianjin 300170, China
  • Published:2023-02-17

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Abstract: Objective To explore the relationship between carotid artery stenosis and white matter structural topological properties in the elderly. Methods According to the North American Symptomatic Carotid Endarterectomy Test(NASCET), 101 elderly people with carotid artery stenosis were divided into mild(n=35), moderate(n=34)and severe(n=32)stenosis groups. The white matter structure network was constructed with deterministic fiber tracking technology. Based on graph theory analysis, the differences among the topological attributes of white matter structure network in the three groups were analyzed. The relationship between the degree of carotid stenosis and topological attributes of white matter structure network was analyzed with multivariate linear regression. Results The local efficiency(Eloc)of severe stenosis group was lower than that of mild and moderate stenosis groups(both P<0.001), and the length of the shortest path(Lp)was greater than that of the other two group(P<0.001, P=0.016). The cluster coefficient(Cp)of moderate and severe stenosis groups was lower than that of mild stenosis group(P=0.009, P<0.001). The small world attribute(σ)of severe stenosis group was lower than that of mild stenosis group(P=0.01). The results of multivariate linear regression showed that the degree of carotid stenosis was negatively related to Eloc, Cp and σ(Eloc: moderate stenosis group β=-0.026, P=0.002, severe stenosis group β=-0.060, P<0.001; Cp: moderate stenosis group β=-0.018, P=0.007, severe stenosis group β=-0.031, P<0.001; σ: moderate stenosis group β=-0.195, P=0.026, severe stenosis group β=-0.301, P=0.001), but positively correlated with Lp(severe stenosis group β=0.346, P=0.007). Conclusion Carotid artery stenosis in the elderly is associated with the topological properties of the white matter structure network, so active prevention and treatment measures should be taken for this population to delay the progression of white matter injury.

Key words: White matter structure network, Topology property, Carotid artery stenosis, Elderly

CLC Number: 

  • R181.3
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