Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 92-97.doi: 10.6040/j.issn.1671-7554.0.2020.1502

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Correlation analysis of acetylcholinesterase activity and inflammatory factors of 45 elderly patients with postoperative delirium

XING Zhiqun, LI Dejun, ZHAO Bao, XU Chunyang, JI Hongsheng   

  1. Department Ⅲ of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2021-04-06

Abstract: Objective To analyze the relationship among plasma acetylcholinesterase activity, inflammatory factors and postoperative delirium in patients who underwent noncardiac surgery. Methods A total of 106 patients transferred to SICU after non-cardiac surgery under general anesthesia during Oct. 2016 and Dec. 2017 were divided into the postoperative delirium group(n=45, case group)and control group(n=61). Delirium was assessed twice daily with the Confusion Assessment Method-Intensive Care Unit(CAM-ICU). The relationship among postoperative delirium, acetylcholinesterase activity and inflammatory factors such as leukocytes procalcitonin(PCT), C-reactive protein(CRP), IL-1β and IL-6 were analyzed. Results There were no statistical difference in baseline data between the two groups, while the APACHE Ⅱ score, PCT, acetylcholinesterase activity and IL-1β were statistically different(P<0.05). Binary Logistic analysis revealed that APACHE Ⅱ score(OR=1.131, 95%CI: 1.011-1.268, P=0.032), and IL-1β (OR=4.209, 95%CI: 1.528-11.592, P=0.005)were independent risk factors of postoperative delirium, while increased acetylcholinesterase activity(OR=0.678, 95%CI: 0.519-0.886, P=0.004)was a protective factor. Conclusion Postoperative delirium in elderly patients is closely related to the severity of disease. IL-1β and decreased acetylcholinesterase activity are independent risk factors of postoperative delirium. Treatment of inflammation and improvement of acetylcholinesterase activity are beneficial to prevent or reduce the occurrence of postoperative delirium, which provides a new idea for the clinical diagnosis and treatment strategies.

Key words: Postoperative delirium, Elderly patients, Acetylcholinesterase activity, Inflammatory factors

CLC Number: 

  • R747.9
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