Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 98-102.doi: 10.6040/j.issn.1671-7554.0.2020.1440

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Correlation between plasma D-dimer and metastasis in 109 cases of bladder cancer

GAO Jinmei1, ZHANG Xianglian2, LIU Tieju3   

  1. 1. Department of Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, China;
    2. Department of Pathology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China;
    3. Department of Pathology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
  • Published:2021-04-06

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Abstract: Objective To explore the correlation between plasma D-dimer and metastasis of bladder cancer. Methods The clinical data of 109 patients with bladder cancer admitted to the Urology Department of The Second Hospital of Tianjin Medical University during Nov. 2018 and Oct. 2020 were respectively analyzed. The patients were divided into metastatic group(n=31)and non-metastatic group(n=78 cases)based on the presence of lymph nodes and/or distant metastasis detected by imaging and pathological examinations. Results of routine blood tests were also collected and analyzed. The independent risk factors of metastasis were analyzed with multivariate Logistic regression model. The diagnostic efficacy of plasma D-dimer of metastasis was evaluated with receiver operating characteristic(ROC)curve. Results The median level of D-dimer was 1.37 mg/L in the metastatic group and 0.53 mg/L in the non-metastatic group. Multivariate Logistic regression showed that elevated plasma D-dimer level might be an independent risk factor of metastasis ［OR(95%CI): 9.542(3.521, 25.935), P<0.05］. The area under the ROC curve was 0.857(P<0.05), and the cut-off point of plasma D-dimer under the maximum Youden index was 1.16 mg/L. The sensitivity, specificity, false negative value and false positive value of D-dimer of bladder cancer metastasis were 65%, 94%, 35% and 6%, respectively. Conclusion Elevated plasma D-dimer level may be an independent risk factor of metastasis of bladder cancer.

Key words: D-dimer, Bladder cancer, Metastasis, Correlation

CLC Number: 

  • R737.14
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