Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (5): 70-73.doi: 10.6040/j.issn.1671-7554.0.2018.185

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Efficacy of atenolol on the treatment of acute coronary syndrome complicated with arrhythmia and the prognosis

GENG Erdong1, NING Juan2   

  1. 1. Department of Emergency, International Hospital of Peking University, Beijing 102206, China;
    2. Department of Oncology, Beijing Huairou Hospital of University of Chinese Academy of Sciences, Beijing 101400, China
  • Received:2018-02-05 Published:2022-09-27

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Abstract: Objective To explore the efficacy of atenolol in the treatment of acute coronary syndrome complicated with arrhythmia and its effect on the prognosis. Methods According to the admission time, 200 patients with acute coronary syndrome complicated with arrhythmia treated during Dec. 2013 and Jan. 2017 were divided into two groups: control group(n=100, received conventional treatment)and treatment group(n=100, received atenolol besides conventional treatment). After 2-week treatment, the levels of blood lipid, high-sensitivity C-reactive protein(hsCRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α)and mortality of the two groups were observed. Results The total effective rate was 95% in the treatment group and 79% in the control group, and the difference was statistically significant(P<0.05). After treatment, the levels of lipid, hsCRP, IL-6 and TNF-α in both groups were significantly higher than those before treatment, and these were superior in the treatment group than in the control group(P<0.05). The mortality was 5% in the treatment group and 20% in the control group(P<0.05). The incidences of grade III and grade IV cardiac function were significantly lower in the treatment group than in the control group(P<0.05). Conclusion Atenolol can not only reduce blood lipid but also inhibit inflammatory reaction and reduce mortality in patients with acute coronary syndrome complicated with arrhythmia.

Key words: Atenolol, Acute coronary syndrome, Arrhythmia, Clinical efficacy, Inflammatory factors

CLC Number: 

  • R451.2
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