Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (11): 82-88.doi: 10.6040/j.issn.1671-7554.0.2022.0177

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Bronchoalveolar lavage fluid cytokine profile contributes to discriminating local inflammation in children with mycoplasma lobar pneumonia

ZHANG Amin1, LI Guosheng2, LI Fuhai1   

  1. 1. Department of Pediatrics;
    2. Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Online:2022-11-10 Published:2022-11-04

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Abstract: Objective To explore the relationship between cytokines in bronchoalveolar lavage fluid(BALF)with lobar pneumonia associated with mycoplasma pneumoniae(MP)in children. Methods A total of 80 children with MP lobar pneumonia treated during Sep. and Dec. 2021 were enrolled. The children were divided into two groups according to metagenome second generation sequencing(mNGS): MP group(n=51), and streptococcus pneumoniae(SP)group(n=29). According to fever duration, The MP group was subdivided into fever duration ≤7 d group(n=22)and >7 d group(n=29). According to pleural effusion, the MP group was subdivided into pleural effusion group(n=18)and non-pleural effusion group(n=33). Cytokines in BALF were compared. Results The levels of IL-6/IL-10 and IL-1β/IL-10 in the BALF of MP group were higher than those in the SP group(P=0.027, P=0.015), while the level of IL-17/IL-10 was lower in MP group than that in SP group(P=0.045). The levels of IL-6/IL-10, IL-1β/IL-10, IL-17/IL-10, IL-12p70/IL-10, IL-4/IL-10 in fever during >7 days were higher than those in the fever duration ≤7 days(P=0.007, P=0.008, P=0.009, P=0.02, P=0.01). The level of IL-6/IL-10 in the pleural effusion group was significantly higher than that in the non-pleural effusion group(P=0.005). The area under the curve(AUC)of IL-6/IL-10, IL-1β/IL-10, IL-17/IL-10, IL-12p70/IL-10, and IL-4/IL-10 in the fever duration >7day were 0.721, 0.719, 0.716, 0.691 and 0.712, respectively. The AUC of IL-6/IL-10 in the pleural effusion group was 0.739. Conclusion The levels of IL-6, IL-1β, IL-17 and IL-4 in BALF of MP lobar pneumonia are associated with the local inflammatory response, which can be used as important indicators to evaluate disease progression in children.

Key words: Lobar pneumonia, Mycoplasma pneumoniae, Children, Bronchoalveolar lavage fluid, Cytokine

CLC Number: 

  • R725.6
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