Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (3): 32-37.doi: 10.6040/j.issn.1671-7554.0.2020.224

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Potential mechanism and research progress of mesenchymal stem cells in the treatment of 2019 novel coronavirus pneumonia

JU Xiuli   

  1. Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Online:2020-03-10 Published:2022-09-27

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Abstract: The current spread of 2019 novel coronavirus pneumonia(2019-nCoV)seriously endangers human health, socio-economic development, as well as the global medical and public health system. The 2019-nCoV is highly contagious and lethal, characterized by long incubation period and difficulty control. More importantly, there is no specific and effective treatment for this disease so far. The cytokine storm caused by excessive immune response is a key factor leading to acute respiratory distress syndrome, septic shock, multiple organ failure, and even death. As mesenchymal stem cells(MSCs)have powerful anti-inflammatory and immunoregulatory potentials, which can inhibit the occurrence and development of cytokine storms and repair tissue damage, MSCs are expected to reduce lung injury, severe complications and mortality. The academic institutes in China have initiated several clinical research projects on MSCs for the treatment of 2019-nCoV, and have preliminarily confirmed its safety, effectiveness and clinical prospect.

Key words: Novel coronavirus pneumonia, Mesenchymal stem cells, Immune regulation, Damage repair, Cytokine storm syndrome

CLC Number: 

  • R563.1
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