Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (5): 1-7.doi: 10.6040/j.issn.1671-7554.0.2021.0319

• Current Advance of Basic and Clinical Medical Virology •     Next Articles

Research progress on factors influencing the protective effects of influenza vaccines

Yuelong SHU*(),Simin WEN   

  1. School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, Guangdong, China
  • Received:2021-03-24 Online:2021-05-10 Published:2021-06-01
  • Contact: Yuelong SHU E-mail:shuylong@mail.sysu.edu.cn

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Abstract:

Annual vaccination is the best prevention of influenza. However, the protective effects of influenza vaccines currently used are poor due to variation of influenza viruses. The protective effects can also be affected by other factors including the genetic factor, and it is important to fully identify these related factors. In this paper, we briefly summarized the factors that may influence the protective effects of influenza vaccines from the aspects of the matching degree of circulating strains and vaccine strains, vaccine factors and host factors, and proposed the development direction of new influenza vaccines in the future.

Key words: Influenza vaccine, Protective effect, Vaccine factors, Host factors

CLC Number: 

  • R186
1 Hswen Y , Brownstein JS , Liu J , et al. Use of a digital health application for in fluenza surveillance in china[J]. Am J Public Health, 2017, 107 (7): 1130- 1136.
doi: 10.2105/AJPH.2017.303767
2 CDC. Seasonal influenza vaccine effectiveness, 2004-2018 [EB/OL]. (2020-12-11)[2021-03-01]. https: //www.cdc.gov/flu/professionals/vaccination/effectiveness-studies.htm.
3 Wen S , Wu Z , Zhong S , et al. Factors influencing the immunogenicity of influenza vaccines[J]. Hum Vaccin Immunother, 2021, 1- 13.
doi: 10.1080/21645515.2021.1875761
4 Simonsen L , Viboud C , Taylor RJ . Effectiveness of influenza vaccination[J]. N Engl J Med, 2007, 357 (26): 2729- 2730.
5 Herrera GA , Iwane MK , Cortese M , et al. Influenza vaccine effectiveness among 50-64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003-2004[J]. Vaccine, 2007, 25 (1): 154- 160.
doi: 10.1016/j.vaccine.2006.05.129
6 Morimoto N , Takeishi K . Change in the efficacy of influenza vaccination after repeated inoculation under antigenic mismatch: a systematic review and meta-analysis[J]. Vaccine, 2018, 36 (7): 949- 957.
doi: 10.1016/j.vaccine.2018.01.023
7 Darvishian M , Dijkstra F , van Doorn E , et al. Influenza vaccine effectiveness in the netherlands from 2003/2004 through 2013/2014: the importance of circulating influenza virus types and subtypes[J]. PLoS One, 2017, 12 (1): e0169528.
doi: 10.1371/joural.pone.0169525
8 Loubet P , Loulergue P , Galtier F , et al. Seasonal influenza vaccination of high-risk adults[J]. Expert Rev Vaccines, 2016, 15 (12): 1507- 1518.
doi: 10.1080/14760584.2016.1188696
9 Sano K , Ainai A , Suzuki T , et al. The road to a more effective influenza vaccine: Up to date studies and future prospects[J]. Vaccine, 2017, 35 (40): 5388- 5395.
doi: 10.1016/j.vaccine.2017.08.034
10 Heikkinen T , Heinonen S . Effectiveness and safety of influenza vaccination in children: European perspective[J]. Vaccine, 2011, 29 (43): 7529- 7534.
doi: 10.1016/j.vaccine.2011.08.011
11 Ambrose CS , Levin MJ , Belshe RB . The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adults[J]. Influenza Other Respir Viruses, 2011, 5 (2): 67- 75.
doi: 10.1111/j.1750-2659.2010.00183.x
12 Cox MM , Hollister JR . FluBlok, a next generation influenza vaccine manufactured in insect cells[J]. Biologicals, 2009, 37 (3): 182- 189.
doi: 10.1016/j.biologicals.2009.02.014
13 Jackson LA , Chen WH , Stapleton JT , et al. Immunogenicity and safety of varying dosages of a monovalent 2009 H1N1 influenza vaccine given with and without AS03 adjuvant system in healthy adults and older persons[J]. J Infect Dis, 2012, 206 (6): 811- 820.
doi: 10.1093/infdis/jis427
14 Vesikari T , Forsten A , Arora A , et al. Influenza vaccination in children primed with MF59-adjuvanted or non-adjuvanted seasonal influenza vaccine[J]. Hum Vaccin Immunother, 2015, 11 (8): 2102- 2112.
doi: 10.1080/21645515.2015.1044167
15 Clark TW , Pareek M , Hoschler K , et al. Trial of 2009 influenza A (H1N1) monovalent MF59-adjuvanted vaccine[J]. N Engl J Med, 2009, 361 (25): 2424- 2435.
doi: 10.1056/NEJMoa0907650
16 CDC. Adjuvanted flu vaccine[EB/OL]. (2021-01-25) [2021-03-01]. https: //www.cdc.gov/flu/prevent/adjuvant.htm.
17 Engler RJ , Nelson MR , Klote MM , et al. Half- vs full-dose trivalent inactivated influenza vaccine (2004-2005): age, dose, and sex effects on immune responses[J]. Arch Intern Med, 2008, 168 (22): 2405- 2414.
doi: 10.1001/archinternmed.2008.513
18 Amadori A , Zamarchi R , De Silvestro G , et al. Genetic control of the CD4/CD8 T-cell ratio in humans[J]. Nat Med, 1995, 1 (12): 1279- 1283.
doi: 10.1038/nm1295-1279
19 Huygen K , Palfliet K . Strain variation in interferon gamma production of BCG-sensitized mice challenged with PPD Ⅱ. Importance of one major autosomal locus and additional sexual influences[J]. Cell Immunol, 1984, 85 (1): 75- 81.
doi: 10.1016/0008-8749(84)90279-X
20 Furman D , Hejblum BP , Simon N , et al. Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination[J]. Proc Natl Acad Sci U S A, 2014, 111 (2): 869- 874.
doi: 10.1073/pnas.1321060111
21 Hewagama A , Patel D , Yarlagadda S , et al. Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis[J]. Genes Immun, 2009, 10 (5): 509- 516.
doi: 10.1038/gene.2009.12
22 Lu FX , Abel K , Ma Z , et al. The strength of B cell immunity in female rhesus macaques is controlled by CD8+ T cells under the influence of ovarian steroid hormones[J]. Clin Exp Immunol, 2002, 128 (1): 10- 20.
doi: 10.1046/j.1365-2249.2002.01780.x
23 Egawa Y , Ohfuji S , Fukushima W , et al. Immunogenicity of influenza A(H1N1)pdm09 vaccine in patients with diabetes mellitus: with special reference to age, body mass index, and HbA1c[J]. Hum Vaccin Immunother, 2014, 10 (5): 1187- 1194.
doi: 10.4161/hv.28252
24 Zimmermann P , Curtis N . The influence of the intestinal microbiome on vaccine responses[J]. Vaccine, 2018, 36 (30): 4433- 4439.
doi: 10.1016/j.vaccine.2018.04.066
25 Mukherjee S , Huda S , Sinha Babu SP . Toll-like receptor polymorphism in host immune response to infectious diseases: A review[J]. Scand J Immunol, 2019, 90 (1): e12771.
doi: 10.1111/sji.12771
26 Didierlaurent A , Ferrero I , Otten LA , et al. Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response[J]. J Immunol, 2004, 172 (11): 6922- 6930.
doi: 10.4049/jimmunol.172.11.6922
27 Yang J , Yan H . TLR5: beyond the recognition of flagellin[J]. Cell Mol Immunol, 2017, 14 (12): 1017- 1019.
doi: 10.1038/cmi.2017.122
28 Oh JZ , Ravindran R , Chassaing B , et al. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination[J]. Immunity, 2014, 41 (3): 478- 492.
doi: 10.1016/j.immuni.2014.08.009
29 Hong SH , Byun YH , Nguyen CT , et al. Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection[J]. Vaccine, 2012, 30 (2): 466- 474.
doi: 10.1016/j.vaccine.2011.10.058
30 Kim JR , Holbrook BC , Hayward SL , et al. Inclusion of flagellin during vaccination against influenza enhances recall responses in nonhuman primate neonates[J]. J Virol, 2015, 89 (14): 7291- 7303.
doi: 10.1128/JVI.00549-15
31 Cui B , Liu X , Fang Y , et al. Flagellin as a vaccine adjuvant[J]. Expert Rev Vaccines, 2018, 17 (4): 335- 349.
doi: 10.1080/14760584.2018.1457443
32 Ciabattini A , Olivieri R , Lazzeri E , et al. Role of the microbiota in the modulation of vaccine immune responses[J]. Front Microbiol, 2019, 10, 1305.
doi: 10.3389/fmicb.2019.01305
33 Andrews SF , Kaur K , Pauli NT , et al. High preexisting serological antibody levels correlate with diversification of the influenza vaccine response[J]. J Virol, 2015, 89 (6): 3308- 3317.
doi: 10.1128/JVI.02871-14
34 Sasaki S , He XS , Holmes TH , et al. Influence of prior influenza vaccination on antibody and B-cell responses[J]. PLoS One, 2008, 3 (8): e2975.
doi: 10.1371/joural.pone.0002975
35 Khurana S , Hahn M , Coyle EM , et al. Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans[J]. Nat Commun, 2019, 10 (1): 3338.
doi: 10.1038/s41467-019-11296-5
36 钟舒怡, 文思敏, 李茂, 等. 免疫相关基因多态性与流感疫苗应答的关联[J]. 中国疫苗和免疫, 2019, 25 (6): 736- 742.
ZHONG Shuyi , WEN Simin , LI Mao , et al. Relationship between immune related single nucleotide polymorphisms and the immune response to influenza vaccine[J]. Chinese Vaccines and Immunization, 2019, 25 (6): 736- 742.
37 Spencer MJ , Cherry JD , Terasaki PI . HL-A antigens and antibody response after influenza a vaccination[J]. N Engl J Med, 1976, 294 (1): 13- 16.
doi: 10.1056/NEJM197601012940104
38 Moss AJ , Gaughran FP , Karasu A , et al. Correlation between human leukocyte antigen class Ⅱ alleles and HAI titers detected post-influenza vaccination[J]. PLoS One, 2013, 8 (8): e71376.
doi: 10.1371/joural.pone.0071376
39 Gelder CM , Lambkin R , Hart KW , et al. Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine[J]. J Infect Dis, 2002, 185 (1): 114- 117.
doi: 10.1086/338014
40 Poland GA , Ovsyannikova IG , Jacobson RM . Immunogenetics of seasonal influenza vaccine response[J]. Vaccine, 2008, 26 (Suppl4): 35- 40.
41 Narwaney KJ , Glanz JM , Norris JM , et al. Association of HLA class Ⅱ genes with clinical hyporesponsiveness to trivalent inactivated influenza vaccine in children[J]. Vaccine, 2013, 31 (7): 1123- 1128.
doi: 10.1016/j.vaccine.2012.12.026
42 Egli A , Santer DM , OShea D , et al. IL-28B is a key regulator of B-and T-cell vaccine responses against influenza[J]. PLoS Pathog, 2014, 10 (12): e1004556.
doi: 10.1371/journal.ppat.1004556
43 Lei N , Li Y , Sun Q , et al. IFITM3 affects the level of antibody response after influenza vaccination[J]. Emerg Microbes Infect, 2020, 9 (1): 976- 987.
doi: 10.1080/22221751.2020.1756696
44 Qin L , Wang D , Li D , et al. High level antibody response to pandemic influenza H1N1/09 virus is associated with interferon-induced transmembrane protein-3 rs12252-CC in young adults[J]. Front Cell Infect Microbiol, 2018, 8, 134.
doi: 10.3389/fcimb.2018.00134
45 Cummins NW , Weaver EA , May SM , et al. Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice[J]. FASEB J, 2012, 26 (7): 2911- 2918.
doi: 10.1096/fj.11-190017
46 国家免疫规划技术工作组流感疫苗工作组. 中国流感疫苗预防接种技术指南(2020-2021)[J]. 中华流行病学杂志, 2020, 41 (10): 1555- 1576.
doi: 10.3760/cma.j.cn112338-20200904-01126
Influenza Vaccine Working Group of Technical Working Group on National Immunization Programme . Technical guidelines for influenza vaccination in China (2020-2021)[J]. Chinese Journal of Epidemiology, 2020, 41 (10): 1555- 1576.
doi: 10.3760/cma.j.cn112338-20200904-01126
47 Wang R , Song A , Levin J , et al. Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein[J]. Antiviral Res, 2008, 80 (2): 168- 177.
doi: 10.1016/j.antiviral.2008.06.002
48 刘雪洁, 赵天旖, 袁丽芳, 等. 通用型流感疫苗的研究现状与展望[J]. 病毒学报, 2021, 37 (2): 471- 482.
LIU Xuejie , ZHAO Tianyi , YUAN Lifang , et al. Research status and prospect of universal influenza vaccine[J]. Chinese Journal of Virology, 2021, 37 (2): 471- 482.
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