Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (1): 34-39.doi: 10.6040/j.issn.1671-7554.0.2021.0274

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Expressions and significance of CDC7 and MCM4 in 105 cases of cervical lesions

CHEN Quancai1,2, HAN Sai1, LIU Lu1,2, SUN Yu1,2, YOU Xuewu1,2, ZHANG Junhua1,2, ZHANG Youzhong1,2   

  1. 1. Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2022-01-08

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Abstract: Objective To explore the expressions and clinical significance of cell division cycle 7(CDC7)and minichromosome maintenance protein 4(MCM4)in cervical cancer and precancerous lesions. Methods The expressions of CDC7 and MCM4 in 30 cases with normal cervix, 30 cases with grade I cervical intraepithelial neoplasia(CINⅠ), 25 cases with CIN Ⅱ-Ⅲ, and 50 cases with cervical cancer were detected with immunohistochemistry. The expressions were compared with Ki67, and their correlation with the clinicopathological characteristics of cervical cancer was analyzed. Results (1) The positive expression rate of CDC7 in normal cervical tissues, CINⅠ, CINⅡ-Ⅲ, and cervical cancer tissues was 6.7%, 26.7%, 56.0% and 78.0%, respectively, which was moderately and positively correlated with the lesion degree(rs=0.625, P<0.001). The positive expression rate of MCM4 in the 4 groups was 26.7%, 36.7%, 64.0% and 88.0%, respectively, which was moderately and positively correlated with the lesion degree(rs=0.680, P<0.001). The positive expression rate of Ki67 in the 4 groups was 10.0%, 26.7%, 60.0% and 84.0%, respectively, which was moderately and positively correlated with the lesion degree(rs=0.660, P<0.001). (2) The positive expression level of CDC7 was correlated with the pathological grade, lymphatic metastasis and depth of muscular invasion of cervical cancer(P=0.024, P=0.033, P=0.023). The positive expression level of MCM4 was correlated with the pathological grade and depth of muscular invasion of cervical cancer(P=0.010, P=0.003). The positive expression level of Ki67 was correlated with the pathological grade, lymphatic metastasis and depth of muscular invasion of cervical cancer(P=0.009, P=0.016, P=0.021). (3) The expression levels of CDC7 and MCM4 were positively correlated in cervical cancer tissues(P=0.001). (4) After multivariate adjustment, the positive expressions of CDC7, MCM4 and Ki67 were risk factor for the severity of cervical lesions. Conclusion CDC7 and MCM4 are highly expressed in CIN and cervical cancer, which suggests that they have potential clinical value as reference indicators for the diagnosis and treatment of CIN and cervical cancer.

Key words: Cervical cancer, Cervical intraepithelial neoplasia, Cell division cycle 7, Minichromosome maintenance protein 4, Antigen Ki67

CLC Number: 

  • R737.33
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