Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 48-54.doi: 10.6040/j.issn.1671-7554.0.2021.0050

Previous Articles     Next Articles

Effect of different ovulation induction regimens for endometrial preparation on the outcome of frozen-thawed embryo transfer among 603 women with polycystic ovary syndrome

GONG Xiaoshu, WU Richao, LI Xiufang, PAN Ye, WANG Ze, SHI Yuhua   

  1. Center for Reproductive Medicine of Shandong University;
    Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250021, Shandong, China
  • Published:2021-04-06

Abstract: Objective To compare the effects of different ovulation induction regimens on pregnancy and maternal and infant outcomes among women with polycystic ovary syndrome(PCOS)during frozen-thawed embryo transfer. Methods Totally 603 frozen-thawed embryo transfer cycles were analyzed by a retrospective study in PCOS population from February 2017 to May 2020. According to the different ovulation induction regimens, the patients were divided into 3 groups: the letrozole group(n=30), the human menopausal gonadotropin(HMG)group(n=344), and the letrozole plus HMG group(n=229). Meanwhile, live birth rate, clinical pregnancy rate, implantation rate, miscarriage rate, the incidence of maternal and infant complications were compared among three groups, respectively. Results There were no significant differences among groups in live birth rate, clinical pregnancy rate, implatation rate, miscarriage rate as well as the incidence of maternal and infant complications(P>0.05). Multivariate Logistic regression analysis also showed no significant differences in live birth rate, clinical pregnancy rate and miscarriage rate among the three groups after adjusting for body mass index(BMI), infertility years, luteinizing hormone(LH), testosterone(To)and anti-millertube hormone(AMH). Conclusion In PCOS patients, different ovulation induction regimens will not affect the pregnancy outcomes and the incidence of maternal and infant complications of frozen-thawed embryo transfer, and appropriate ovulation induction regimens should be selected based on patients conditions during clinical practice.

Key words: Ovulation induction, Polycystic ovary syndrome, Frozen-thawed embryo transfer, Endometrial preparation, Live birth rate

CLC Number: 

  • R711.6
[1] 中华医学会妇产科学分会内分泌学组及指南专家组. 多囊卵巢综合征中国诊疗指南[J]. 中华妇产科杂志,2018, 53(1): 2-6.
[2] Costello MF, Misso mL, Balen A, et al. A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome [J]. Aust N Z J Obstet Gynaecol, 2019, 59(6): 867-873.
[3] Chen ZJ, Shi Y, Sun Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome [J]. N Engl J Med, 2016, 375(6): 523-533.
[4] Wei D, Yu Y, Sun M, et al. The effect of supraphysiological estradiol on pregnancy outcomes differs between women with PCOS and ovulatory women [J]. J Clin Endocrinol Metab, 2018, 103(7): 2735-2742.
[5] Hatoum I, Bellon L, Swierkowski N, et al. Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer: the risk of early pregnancy loss in frozen embryo transfer cycles [J]. J Assist Reprod Genet, 2018, 35(3): 425-429.
[6] Tatsumi T, Jwa SC, Kuwahara A, et al. Pregnancy and neonatal outcomes following letrozole use in frozen-thawed single embryo transfer cycles [J]. Hum Reprod, 2017, 32(6): 1244-1248.
[7] Zhang J, Liu H, Wang Y, et al. Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome [J]. Fertil Steril, 2019, 112(2): 371-377.
[8] 王敏.多囊卵巢综合征患者采取不同促排卵方案对其子宫及卵巢血流的影响研究[J].中国实用医药, 2020, 15(5): 136-138.
[9] Legro RS, Brzyski RG, Diamond MP, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome [J]. N Engl J Med, 2014, 371(2): 119-129.
[10] Lin J, Wang N, Huang J, et al. Pregnancy and neonatal outcomes of hMG stimulation with or without letrozole in endometrial preparation for frozen-thawed embryo transfer in ovulatory women: a large retrospective cohort study [J]. Drug Des Devel Ther, 2019, 13: 3867-3877. doi: 10.2147/DDDT.S212235.
[11] Dai L, Deng C, Li Y, et al. Birth weight reference percentiles for Chinese [J]. PLoS One, 2014, 9(8): e104779. doi: 10.1371/journal.pone.0104779.
[12] Dai L, Deng C, Li Y, et al. Population-based birth weight reference percentiles for Chinese twins [J]. Ann Med, 2017, 49(6): 470-478.
[13] Hu YJ, Chen YZ, Zhu YM, et al. Letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in women with polycystic ovarian syndrome: a pilot study [J]. Clin Endocrinol(Oxf), 2014, 80(2): 283-289.
[14] Miller PB, Parnell BA, Bushnell G, et al. Endometrial receptivity defects during IVF cycles with and without letrozole [J]. Hum Reprod, 2012, 27(3): 881-888.
[15] Wallace KL, Johnson V, Sopelak V, et al. Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome [J]. Fertil Steril, 2011, 96(4): 1051-1056.
[16] Noyes N, Liu HC, Sultan K, et al. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization [J]. Hum Reprod, 1995, 10(4): 919-922.
[17] El-Toukhy T, Coomarasamy A, Khairy M, et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles [J]. Fertil Steril, 2008, 89(4): 832-839.
[18] 姜小花,徐玉萍,魏兆莲,等.子宫厚度对PCOS冻胚移植周期妊娠结局的影响[J].安徽医科大学学报, 2020, 55(10): 1633-1636. JIANG Xiaohua, XU Yuping, WEI Zhaolian, et al. Effect of uterine thickness on pregnancy outcomes of frozen embryo transfer in PCOS patients [J]. Acta Universitatis Medicinalis Anhui, 2020, 55(10): 1633-1636.
[19] Samsami A, Ghasmpour L, Davoodi S, et al. Frozen embryo transfer: endometrial preparation by letrozole versus hormone replacement cycle: a randomized clinical trial [J]. Int J Reprod Biomed, 2019, 17(12): 915-922.
[20] Pritts EA, Yuen AK, Sharma S, et al. The use of high dose letrozole in ovulation induction and controlled ovarian hyperstimulation [J]. ISRN Obstet Gynecol, 2011, 17(12): 915-922.
[21] Yu J, Ma Y, Wu Z, et al. Endometrial preparation protocol of the frozen-thawed embryo transfer in patients with polycystic ovary syndrome [J]. Arch Gynecol Obstet, 2015, 291(1): 201-211.
[22] Zong L, Liu P, Zhou L, et al. Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer [J]. Reprod Biol Endocrinol, 2020, 18(1): 36. doi: 10.1186/s12958-020-00601-3.
[23] Wang Z, Liu H, Song H, et al. Increased risk of pre-eclampsia after frozen-thawed embryo transfer in programming cycles [J]. Front Med(Lausanne), 2020, 7: 104. doi: 10.3389/fmed.2020.00104.
[24] 田海清,门鸿芹,张萌,等.自然周期与激素替代周期的冻融胚胎移植方案对单胎妊娠新生儿结局的影响研究[J].中国全科医学, 2020, 23(21): 2673-2677. TIAN Haiqing, MEN Hongqin, ZHANG Meng, et al. Singleton Pregnancy outcomes in frozen-thawed embryo transfer in natural cycle and hormone replacement therapy cycle: a comparative study[J]. Chinese General Practice, 2020, 23(21): 2673-2677.
[25] Lim SS, Davies MJ, Norman RJ, et al. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis [J]. Hum Reprod Update, 2012, 18(6): 618-637.
[26] 孙晓玲.多囊卵巢综合征患者血清DHEAS、Angptl2、CTGF水平变化及其与HOMR-IR、BMI的相关[J].中国实用医刊, 2020, 27(9): 79-83. SUN Xiaoling. Changes of levels of DHEAS, Angptl2, CTGF and their correlations with HOMR-IR and BMI in patients with polycystic ovary syndrome[J]. Chinese Journal of Practical Medicine, 2020, 27(9): 79-83.
[27] Lin J, Huang J, Wang N, et al. Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women with PCOS undergoing frozen embryo transfer [J]. BMC Pregnancy Childbirth, 2019, 19(1): 487. doi: 10.1186/s12884-019-2611-1.
[1] SONG Tian, FU Linlin, WANG Qiumin, YANG Xiao, WANG Ying, BIAN Yuehong, SHI Yuhua. Expression of fatty acid transport protein 1 in granulosa cells of patients with polycystic ovary syndrome [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 22-26.
[2] HAN Xiao, LI Lei, LIU Congcong. Effect of testosterone on the expression of polycystic ovary syndrome susceptibility gene Tox3 in zebrafish [J]. Journal of Shandong University (Health Sciences), 2021, 59(4): 42-47.
[3] HA Lingxia, YIN Ting, WU Yangyang, LI Weixia, DU Yudong. Correlation between insulin resistance and expressions of local inflammatory factors and glucose transporter protein type-4 in the endometrium of patients with polycystic ovary syndrome [J]. Journal of Shandong University (Health Sciences), 2021, 59(11): 41-47.
[4] DING Xiangyun, YU Qingmei, ZHANG Wenfang, ZHUANG Yuan, HAO Jing. Correlation of the expression of insulin-like growth factor II in granulosa cells and ovulation induction outcomes of 84 patients with polycystic ovary syndrome [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 60-66.
[5] ZHANG Xiuqing, ZHANG Jing, JIANG Qi, LI Chen, LIU Chang, LI Ruijing, FENG Huijuan, GENG Ling. Effect of intracavitary physiotherapy on pregnancy outcomes of 89 patients with thin endometrium in frozen-thawed embryo transfer cycles [J]. Journal of Shandong University (Health Sciences), 2020, 58(5): 62-68.
[6] SONG Haixia,YUAN Caixia,FAN Lingling. Impact of body mass index on pregnancy outcomes in artificial insemination by husband [J]. Journal of Shandong University (Health Sciences), 2020, 58(1): 49-53.
[7] HE Tingting, LIU Hong, SHU Kaiyun, SONG Xiaocui, SHI Yuhua. Expression and significance of microRNA-141 in granulosa cells of patients with polycystic ovary syndrome [J]. Journal of Shandong University (Health Sciences), 2019, 57(5): 116-120.
[8] HE Tingting, LIU Xin, LIU Hongbin, ZHAO Shigang, ZHANG Xiuqing, LIU Qingqing, YOU Li, SHI Yuhua. Expression of Forkhead box protein O1 mRNA in granulosa cells of polycystic ovary sydrome patients and its significance [J]. Journal of Shandong University (Health Sciences), 2019, 57(2): 75-79.
[9] LIU Congcong, LIU Hongbin, FU Jiang, LI Lei. Expression of polycystic ovary syndrome susceptibility gene dennd1a in zebrafish models [J]. Journal of Shandong University (Health Sciences), 2019, 57(1): 48-54.
[10] SHU Xin, WANG Qun, HUANG Tao, ZHAO Shigang, SHI Yuhua, LIU Hongbin. Expression of FBP1 in granulosa cells of PCOS patients with hyperandrogenism and its significance [J]. Journal of Shandong University (Health Sciences), 2018, 56(4): 58-63.
[11] ZHANG Suping, WANG Ze, ZHOU Yali, LI Jing, LU Xilan, BAI Hongwei, SHI Yuhua. Clinical effects of body mass index on ovulation induction treatment with letrozole among women with polycystic ovary syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 81-85.
[12] LI Jingbo, LIU Hongbin, JIA Yueyue, WANG Ze, SUN Mei, SHI Yuhua. Expression and clinical significance of microRNA-183 in polycystic ovary syndrome with insulin resistance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 69-74.
[13] YANG Dongzi, MAI Zhuoyao. Features of ovarian reserve and outcomes of assisted reproductive technology in elder patients with PCOS [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 26-32.
[14] ZHANG Lin, LI Jing, WANG Ze, ZHANG Jiangtao, MA Zengxiang, SHI Yuhua. Impact of thyroid-stimulating hormone on blood glucose and serum lipids in patients with polycystic ovary syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 80-84.
[15] JIA Yueyue, LIU Hongbin, LI Jingbo, LI Jing, ZHANG Jiangtao, SUN Mei, SHI Yuhua. Expression of microRNA-200b in granulosa cells of PCOS patients and its significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 63-68.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] ZHENG Min,HAO Yue-wei,LIU Xue-ping,ZHAO Ting-ting. Relationship between the HPA-2 and Kozak sequence polymorphism of platelet membrane glycoprotein and cerebral infarction[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(3): 292 -295 .
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(10): 995 .
[3] JIANG Hong-ju,LI Run-zhi, WANG Ying,XU Dong-mei,ZHANG Mei,ZHANG Yun,LI Ji-fu. Relationship between the plasma level of matrix metalloproteinase-9 and structural characteristics of plaques and percutaneous coronary intervention [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 966 -970 .
[4] WANG Shu-qin,QI Feng,WU Jian-bo,SUN Bao-zhu. Effect of calcium in ropivacaine-induced smooth muscle contraction of the aorta in rats in vitro[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(8): 773 -776 .
[5] TENG Xue-ren,ZHAO Yong-sheng,HU Guang-liang,ZHOU Lun,LI Jian-min. Characteristics of microcosmic changes following tendon allograft transplantation preserved by two methods under light microscopy and transmission electron microscopy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 945 -950 .
[6] WU Min,ZHAO Zhi-lun,WANG Jie-zhen. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(11): 1146 -1149 .
[7] ZHANG Jie,LI Zhen-hua,SUN Jin-hao,BAO Li-hua,LIU Yue-peng. Protective effects of the invariable magnetic field on oxidative injured Schwann cells[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 229 -232 .
[8] ZHAO Peng,BI Wan-li,LI Ning. Post-processing techniques of spiral CT in adolescent congenital spinal deformity[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(8): 825 -829 .
[9] YANG Xi1, GAO Peng2, XUE Yuwen1, WANG Yan2, LIU Wenjun2, ZHANG Xiaofang2
. Expression of DNA methyltransferase 1(DNMT1)in lung adenocarcinoma and its prognosis significance[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(01): 30 -33 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(8): 828 -830 .