Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 48-54.doi: 10.6040/j.issn.1671-7554.0.2021.0050

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Effect of different ovulation induction regimens for endometrial preparation on the outcome of frozen-thawed embryo transfer among 603 women with polycystic ovary syndrome

GONG Xiaoshu, WU Richao, LI Xiufang, PAN Ye, WANG Ze, SHI Yuhua   

  1. Center for Reproductive Medicine of Shandong University;
    Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250021, Shandong, China
  • Published:2021-04-06

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Abstract: Objective To compare the effects of different ovulation induction regimens on pregnancy and maternal and infant outcomes among women with polycystic ovary syndrome(PCOS)during frozen-thawed embryo transfer. Methods Totally 603 frozen-thawed embryo transfer cycles were analyzed by a retrospective study in PCOS population from February 2017 to May 2020. According to the different ovulation induction regimens, the patients were divided into 3 groups: the letrozole group(n=30), the human menopausal gonadotropin(HMG)group(n=344), and the letrozole plus HMG group(n=229). Meanwhile, live birth rate, clinical pregnancy rate, implantation rate, miscarriage rate, the incidence of maternal and infant complications were compared among three groups, respectively. Results There were no significant differences among groups in live birth rate, clinical pregnancy rate, implatation rate, miscarriage rate as well as the incidence of maternal and infant complications(P>0.05). Multivariate Logistic regression analysis also showed no significant differences in live birth rate, clinical pregnancy rate and miscarriage rate among the three groups after adjusting for body mass index(BMI), infertility years, luteinizing hormone(LH), testosterone(To)and anti-millertube hormone(AMH). Conclusion In PCOS patients, different ovulation induction regimens will not affect the pregnancy outcomes and the incidence of maternal and infant complications of frozen-thawed embryo transfer, and appropriate ovulation induction regimens should be selected based on patients conditions during clinical practice.

Key words: Ovulation induction, Polycystic ovary syndrome, Frozen-thawed embryo transfer, Endometrial preparation, Live birth rate

CLC Number: 

  • R711.6
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