Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 58-63.doi: 10.6040/j.issn.1671-7554.0.2017.998

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Expression of FBP1 in granulosa cells of PCOS patients with hyperandrogenism and its significance

SHU Xin, WANG Qun, HUANG Tao, ZHAO Shigang, SHI Yuhua, LIU Hongbin   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    Key Laboratory for Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan 250001, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the expression and significance of FBP1 in ovarian granulosa cells in patients with polycystic ovary syndrome(PCOS). Methods A total of 28 PCOS patients with hyperandrogenism(hyperandrogenism group), 72 PCOS patients without hyperandrogenism(non-hyperandrogenism group)and 58 healthy controls(control group)were enrolled. The expressions of FBP1 in the ovarian granulosa cells of the three groups were examined with real-time quantitative reverse transcription PCR(qRT-PCR). The correlation between FBP1 and androgen-related indicators was analyzed. The patients age, body mass index(BMI)and related hormones were analyzed. Results The hyperandrogenism group had higher incidence of obesity, hypertensive disease, hyperglycemia, metabolic syndrome and morbidity than the non-hyperandrogenism and control groups(P<0.05). The mRNA expression of FBP1 was higher in the hyperandrogenism group than that in the non-hyperandrogenism group(P=0.038)and control group(P=0.002). There was positive correlation between dehydroepiandrosterone sulfate(DHE-S)and the mRNA expression of 山 东 大 学 学 报 (医 学 版)56卷4期 -舒心,等.多囊卵巢综合征高雄激素血症患者颗粒细胞FBP1基因的表达及影响 \=-FBP1 in the hyperandrogenism group(r=0.470, P=0.021). Conclusion High expression of FBP1 is associated with hyperandrogenism of PCOS and DHE-S, and may be involved in the pathogenesis of PCOS hyperandrogenism through follicular microenvironment.

Key words: Polycystic ovary syndrome, FBP1 gene, Granulosa cell, Hyperandrogenism, Dehydroepiandrosterone sulfate

CLC Number: 

  • R711.75
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