Journal of Shandong University (Health Sciences) ›› 2017, Vol. 55 ›› Issue (12): 24-30.doi: 10.6040/j.issn.1671-7554.0.2017.154

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Damage of bronchus and lung tissue in healthy mice after aerosol inhalation and intratracheal administration of amikacin and tigecycline

ZHENG Liang1, QI Qian1, ZHOU Yufa1, LI Yu2   

  1. 1. Department of Respiratory Disease, Laiwu City Peoples Hospital, Laiwu 271100, Shandong, China;
    2. Department of Respiratory Disease, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Online:2017-12-20 Published:2022-09-27

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Abstract: Objective To compare bronchus and lung tissue damage of healthy mice after aerosol inhalation and intratracheal administration of amikacin and tigecycline. Methods One hundred and forty-four Kunming species of mice were randomly divided into 9 groups(16 mice per group): blank control group, normal saline inhalation group, amikacin low concentration inhalation group, amikacin high concentration inhalation group, tigecycline low concentration inhalation group, tigecycline high concentration inhalation group, normal saline intratracheal administration group, amikacin intratracheal administration group and tigecycline intratracheal administration group. Each group was given the corresponding treatment. Then bronchus and lung tissue pathological specimens of each group of mice were obtained. The bronchus and lung tissue damage was compared among each group. Results Alveolar damage scores of tigecycline high concentration inhalation group and amikacin high concentration inhalation group were significantly higher than that of blank control group(P=0.001; P<0.001). Alveolar damage scores of amikacin high concentration inhalation group was significantly higher than that of normal saline intratracheal administration group(P<0.001)and tigecycline intratracheal administration group(P=0.001). Conclusion Alveolar might be damaged by aerosol inhalation or intratracheal 山 东 大 学 学 报 (医 学 版)55卷12期 -郑亮,等.雾化吸入及气管滴入阿米卡星、替加环素对健康小鼠支气管和肺组织的损伤 \=-administration of amikacin and tigecycline. The lung tissue damage after aerosol inhalation of amikacin might be more serious than intratracheal administration of tigecycline.

Key words: Aerosol inhalation, Intratracheal administration, Amikacin, Tigecycline, Bronchus, Lung tissue, Damage

CLC Number: 

  • R37
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