Abstract: Objective To investigate the long-term prognosis of women who suffered preeclampsia and the risk of preeclampsia in their female offspring. Methods A total of 311 women with a history of preeclampsia were recruited as the observation group, while 328 women with normal delivery were enrolled as the control group. Both groups satisfied the following criteria: no history of hypertention, diabetes, renal diseases, cardiovascular and brain diseases, or other medical complications before pregnancy. The occurrence of hypertension, cardiovascular diseases and preeclampsia during pregnancy in the female offspring of these subjects were analyzed with χ2 test. Results The incidence of hypertension(23.79% vs 8.23%, P<0.001), diabetes(11.25% vs 6.71%, P=0.044), microalbuminuria(21.54% vs 6.10%, P<0.001), chronic kidney disease(10.29% vs 5.79%, P=0.036), heart failure(2.57% vs 0.61%, P=0.046), and stroke(3.22% vs 0.91%, P=0.039)were higher in the observation group than those in the control group. Long-term prognosis figures showed that the differences between the two groups were statistically significant(P<0.05). The incidence of preeclampsia in the female offspring of women with history of preeclampsia was significantly higher than those without history of preeclampsia (OR: 5.35; 95% CI: 2.20~12.97). Conclusion Preeclampsia is a risk factor for long-term cardiovascular disease. The female offspring of women with history of preeclampsia have increased risks of preeclampsia during pregnancy. For women with family history of preeclampsia, prenatal checkup should be strength- 山 东 大 学 学 报 (医 学 版)55卷12期 -王润梅,等. 子痫前期患者远期预后及其后代发病风险的评估 \=-ened and prevention measures should be taken early enough so as to improve the long-term prognosis.

Key words: Preeclampsia, Long-term prognosis, Offspring, Family history, Recurrence, Prevention and control