Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (5): 56-61.doi: 10.6040/j.issn.1671-7554.0.2019.1204

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Association between cognitive impairment and thyroid function after acute ischemic stroke in 94 patients with type 2 diabetes mellitus

WANG Yuyu, GAO Li, CHEN Shaohua   

  1. Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To investigate the relationship between cognitive impairment and thyroid-related hormones after acute ischemic stroke in patients with type 2 diabetes mellitus(T2DM). Methods A total of 94 T2DM complicated with acute ischemic stroke were randomly selected as research objects, and were divided into the cognitive impairment group(n=54)and cognitive normal group(n=40)according to Montreal Cognitive Assessment(MoCA )scales. The differences of thyroid-related hormones, biochemical indicators and general information were compared between the two groups, and the independent risk factors of cognitive impairment after acute ischemic stroke were analyzed with multivariate binary Logistic regression analysis. Results Univariate analysis showed that the cognitive impairment group had higher level of thyroxine stimulating hormone(TSH)［(2.17±1.12)vs(1.29±0.71)μIU/mL, t=-4.618, P<0.001］, lower level of free triiodothyronine(FT3)［(3.80±0.70)vs(4.62±0.79)pmol/L, t=5.290, P<0.001］, higher incidence of cerebral infarction and higher level of glycosylated hemoglobin than the cognitive normal group (P<0.05). There were no statistical differences in sex, age, education level, living habits(smoking, drinking), basic diseases(hypertension, coronary heart disease), body mass index, systolic blood pressure, diastolic blood pressure, number of cerebral infarction foci, location of infarction, fasting plasma glucose, blood lipids and free thyroxine(FT4)between the two groups (P>0.05). After age, sex, education level, previous acute ischemic stroke history, basic diseases, living habits, fasting plasma glucose and blood lipids were adjusted, multivariate binary Logistic regression analysis showed that TSH (OR=8.159, 95%CI=2.128-31.277)might be an independent risk factor of cognitive impairment, while FT3 (OR=0.033, 95%CI=0.005-0.234) might be a protective factor. Conclusion Elevated TSH may be an independent risk factor of cognitive impairment after acute ischemic stroke in T2DM patients, while FT3 may be a protective factor.

Key words: Type 2 diabetes mellitus, Acute ischemic stroke, Free triiodothyronine, Thyroid stimulating hormone, Cognitive impairment, Montreal Cognitive Assessment(MoCA)scales

CLC Number: 

  • R587
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