Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (2): 22-26.doi: 10.6040/j.issn.1671-7554.0.2021.1148

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Expression of fatty acid transport protein 1 in granulosa cells of patients with polycystic ovary syndrome

SONG Tian, FU Linlin, WANG Qiumin, YANG Xiao, WANG Ying, BIAN Yuehong, SHI Yuhua   

  1. Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University;
    Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University;
    Shandong Key Laboratory of Reproductive Medicine;
    Shandong Provincial Clinical Research Center for Reproductive Health;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan 250012, Shandong, China
  • Published:2022-01-25

Abstract: Objective To investigate the expression of fatty acid transport protein 1(FATP1)in granulosa cells of patients with polycystic ovary syndrome(PCOS)and its clinical significance. Methods A total of 75 PCOS patients(PCOS group)undergoing in vitro fertilization-embryo transform(IVF-ET)were selected. According to the standard of body mass index(BMI)≥ 25 as obesity, the subjects were divided into normal BMI PCOS group(n=36)and obese PCOS group(n=39). Another 62 patients(control group)seeking assisted reproduction treatment due to tubal or male factors were divided into normal BMI control group(n=31)and obese control group(n=31). The expression of FATP1 in patients granulosa cells was detected with reverse transcription real-time quantitative PCR(qRT-PCR), and its differential expression in PCOS patients was analyzed. Results The expression of FATP1 was higher in PCOS group than in controls(P<0.001), higher in the normal BMI PCOS group than in normal BMI control group(P<0.001), and higher in obese PCOS group than in obese control group(P<0.001). Binary Logistic regression analysis showed that higher FATP1 level(OR=4.242, 95%CI: 2.025-8.883, P<0.001), higher anti-Mullerian hormone level(AMH, OR=1.512, 95%CI: 1.186-1.928, P<0.001), higher luteotropic hormone/follicle stimulating hormone ratio(LH/FSH, OR=4.401, 95%CI: 1.265-15.304, P=0.02), and higher testosterone level(T, OR=1.059, 95%CI: 1.003-1.117, P=0.038)were risk factors of PCOS. Conclusion The expression of FATP1 is increased in PCOS patients, suggesting that FATP1 may play an important role in the development of PCOS.

Key words: Fatty acid transport protein1, Polycystic ovary syndrome, Granulosa cells, Fatty acid, Proliferation

CLC Number: 

  • R711.75
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