Abstract: Objective To analyze the effect of thyroid stimulating hormone(TSH)on blood glucose and serum lipids in patients with polycystic ovary syndrome(PCOS). Methods A total of 1 034 PCOS patients without thyroid disease history were collected. Their height, weight, waist circumference(WC), hip circumference(HC), blood pressure, TSH, sex hormones, blood glucose, insulin, serum lipids were measured; body mass index(BMI), waist hip ratio, and homeostasis model assessment of insulin resistance(HOMA-IR)were calculated. Based on the normal TSH cut-off adopted in our hospital, the PCOS patients were divided into two groups: normal TSH group(0.27 μIU/mL≤TSH≤4.2 μIU/mL)and elevated TSH group(TSH>4.2 μIU/mL). The biochemical indicators of the two groups were compared. Results 山 东 大 学 学 报 (医 学 版)55卷1期 -张琳,等.多囊卵巢综合征患者促甲状腺激素对血糖、血脂的影响 \=-Of all patients, 163(15.76%)had elevated TSH level. There were significant differences between the elevated and normal TSH groups in body weight(P=0.015), BMI(P=0.021), WC(P=0.023), systolic pressure(P=0.006), and diastolic pressure(P=0.001). The prevalence of obesity was significantly higher in elevated TSH group than in normal TSH group. There are no significant differences between the two groups in 2 h blood glucose, FINS, 2 h insulin, and HOMA-IR(all P>0.05), but there was a rising trend in the elevated TSH group. The elevated TSH group had higher TC(P=0.027), TG(P=0.022)and LDL-C(P=0.049)than those of the normal TSH group. TSH was positively correlated to hip circumference, systolic pressure, diastolic blood pressure, FINS, 2 h insulin, HOMA-IR, TC, TG and LDL-C(all P<0.05). Conclusion PCOS patients with TSH elevated are prone to obesity, dyslipidemia, glucose metabolism disorder and insulin resistance. Therefore, such patients are suggested to have TSH level screened.

Key words: Thyroid stimulating hormone, Serum lipids, Blood glucose, Polycystic ovary syndrome