JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (6): 87-90.doi: 10.6040/j.issn.1671-7554.0.2015.493

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Correlation of QuantiFERON-TB gold in-tube test result with age of adults

BU Fanfeng1,2, SUN Xiaxia1, LIANG Xiaoling1   

  1. 1. Jinan Kingmed Center for Clinical Laboratory, Jinan 250101, Shandong, China;
    2. Tianjin Kingmed Institute for Clinical Laboratory, Tianjin 300384, China
  • Received:2015-05-15 Online:2016-06-20 Published:2016-06-20

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Abstract: Objective To explore the relationship between age and release of interferon gamma in blood of adults through the correlation analysis of age and QuantiFERON-TB gold in-tube test(QFT-GIT)results. Methods A total of 168 patients with positive results of QFT-GIT were divided into three groups according to the age:18 to 40 years group, 41 to 65 years group and elder than 65 years group. The changes of IFN-γ response to TB-specific antigen(TB Ag-Nil)and non-specific phytohemagglutinin(Mitogen-Nil)were compared among the three groups. Spearman correlation analysis was used to calculate the correlation coefficient value γ. Linear regression analysis was used to show the change. Results The change trend of TB Ag-Nil and Mitogen-Nil in 18 to 40 years group and 41 to 65 years group were not statistically significant(P>0.05). However in patients elder than 65 years, the levels of TB Ag-Nil and Mitogen-Nil decreased significantly with age increasing(P<0.05). Conclusion For patients of 18 to 65 years, the results of QFT-GIT are not related to the age, but for those elder than 65 years, TB Ag-Nil and Mitogen-Nil is negatively related to the age.

Key words: Mycobacterium, QuantiFERON-TB gold in-tube test, Age

CLC Number: 

  • R446.61
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